In this paper, we present a new methodology to develop arbitrary high-order structure-preserving methods for solving the quantum Zakharov system. The key ingredients of our method are: (i) the original Hamiltonian energy is reformulated into a quadratic form by introducing a new quadratic auxiliary variable; (ii) the original system is then rewritten into a new equivalent system which inherits the quadratic energy based on the energy variational principle; (iii) the resulting system is discretized by symplectic Runge-Kutta method in time combining with the Fourier pseudo-spectral method in space. The proposed method achieves arbitrary high-order accurate in time and can preserve the discrete mass and Hamiltonian energy exactly. Moreover, an efficient iterative solver is presented to solve the resulting discrete nonlinear equations. Finally, extensive numerical examples are provided to demonstrate the theoretical claims and illustrate the efficiency of our method.