Various loads have a significant effect on the operation of different equipment components. Modern national and international studies show high efficiency of applying finite element methods to research into the loading nature of various parts and systems as a whole. Unevenly distributed loads can reduce the performance of the equipment, as well as lead to the failure of components. This paper examines the effect of the position of the substrate gripper system on the deformations in the printing cylinder. The findings prove that the misalignment of the shaft and gripper bridge placement doubles the resulting deformations.