Geometric strategies for neuroanatomic analysis from MRI

Duncan, James S.; Papademetris, Xenophon; Yang, Jing; Jackowski, Marcel P.; Zeng, Xiangyan; Staib, Lawrence H.

doi:10.1016/j.neuroimage.2004.07.027

Cited by 102 publications

(87 citation statements)

References 66 publications

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“…The sustained effects of rehearsal were similarly coded by convolving a block-length boxcar function with this gamma function (Boynton et al, 1996;Visscher et al, 2003). Prior to across-subjects comparisons, fMRI data were spatially normalized to standard stereotactic space using an affine transformation (Duncan et al, 2004). Group by smoking condition interaction effects on task-related activation were assessed using voxelwise mixed-model repeated-measures analysis of variance (ANOVA) (Woods, 1996;Kirk, 1982;Holmes and Friston, 1998), with group assignment as a between-subjects variable, smoking condition as a within-subjects variable, and subject treated as random effect within each group.…”

Section: Discussionmentioning

confidence: 99%

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

Jacobsen

Slotkin

Westerveld

et al. 2005

Neuropsychopharmacol

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Active maternal smoking during pregnancy elevates the risk of cognitive deficits and tobacco smoking among offspring. Preclinical work has shown that combined prenatal and adolescent exposure to nicotine produces more pronounced hippocampal changes and greater deficits in cholinergic activity upon nicotine withdrawal than does prenatal or adolescent exposure to nicotine alone. Few prior studies have examined the potential modifying effects of gestational exposure to active maternal smoking on cognitive or brain functional response to tobacco smoking or nicotine withdrawal in adolescents. We examined visuospatial and verbal memory in 35 adolescent tobacco smokers with prenatal exposure to active maternal smoking and 26 adolescent tobacco smokers with no prenatal exposure to maternal smoking who were similar in age, educational attainment, general intelligence, and baseline plasma cotinine. Subjects were studied during ad libitum smoking and after 24 h of abstinence from smoking. A subset of subjects from each group also underwent functional magnetic resonance imaging while performing a visuospatial encoding and recognition task. Adolescent tobacco smokers with prenatal exposure experienced greater nicotine withdrawal-related deficits in immediate and delayed visuospatial memory relative to adolescent smokers with no prenatal exposure. Among adolescent smokers with prenatal exposure, nicotine withdrawal was associated with increased activation of left parahippocampal gyrus during early recognition testing of visuospatial stimuli and increased activation of bilateral hippocampus during delayed recognition testing of visuospatial stimuli. These findings extend prior preclinical work and suggest that, in human adolescent tobacco smokers, prenatal exposure to active maternal smoking is associated with alterations in medial temporal lobe function and concomitant deficits in visuospatial memory.

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Section: Discussionmentioning

confidence: 99%

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

Jacobsen

Slotkin

Westerveld

et al. 2005

Neuropsychopharmacol

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“…Electrode locations were identified in a high-resolution postoperative brain CT, and then transformed onto a high-resolution preoperative brain MRI by volumetrically coregistering the preoperative and postoperative scans in Bioimage Suite. 22 One or more viewpoint snapshots were then aggregated into a single image to visualize functional activations relative to individual anatomy.…”

Section: Methods Patients and Clinical Settings Seven English-mentioning

confidence: 99%

Spatial-temporal functional mapping of language at the bedside with electrocorticography

et al. 2016

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Objective: To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery.Methods: We developed and tested an online system that exploits ECoG's temporal resolution to display the evolution of statistically significant high gamma (70-110 Hz) responses across all recording sites activated by a discrete cognitive task. We illustrate how this spatial-temporal evolution can be used to study the function of individual recording sites engaged during different language tasks, and how this approach can be particularly useful for mapping eloquent cortex.Results: Using electrocortical stimulation mapping (ESM) as the clinical gold standard for localizing language cortex, the average sensitivity and specificity of online STFM across 7 patients were 69.9% and 83.5%, respectively. Moreover, relative to regions of interest where discrete cortical lesions have most reliably caused language impairments in the literature, the sensitivity of STFM was significantly greater than that of ESM, while its specificity was also greater than that of ESM, though not significantly so. Functional human brain mapping is commonly performed during or prior to invasive brain surgery for the treatment of drug-refractory epilepsy 1,2 and brain tumors. 3 The current gold standard, electrocortical stimulation mapping (ESM), is time-consuming 4,5 and often induces afterdischarges or seizures. 4,6,7 Additionally, it is difficult to rule out distant effects through diaschisis or action potentials evoked by stimulation.7-9 These limitations have long motivated the investigation of passive electrocorticographic (ECoG) recordings as a tool for rapidly and safely mapping cortical function prior to resective surgery. 10-12Here we introduce and test the feasibility and clinical utility of an online trial-based system for spatial-temporal functional mapping (STFM) of language cortex. High-gamma (HG, ; power changes have been demonstrated to be a robust and reliable index of task-related activation of cortical populations of neurons with high spatial and temporal specificity.13,14 The STFM system builds upon previous passive ECoG mapping software [15][16][17][18] by providing a trialbased framework for online display and statistical validation of HG dynamics.In 7 patients, estimates of the system's sensitivity and specificity for language mapping, relative to the benchmark of ESM, were the same or better than previous reports.18-21 Moreover, we found that relative to predefined language cortex boundaries, the sensitivity and specificity of *These authors contributed equally to this work.

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“…bioimagesuite.org) (41,42). The first registration performs a linear registration between the individual subject raw functional image and that subject's 2D anatomical image.…”

Section: Figurementioning

confidence: 99%

“…Results were masked and converted back into ANALYZE format for viewing in BioImage Suite. Whole-brain, voxel-based correlation analyses with plasma glucose and cortisol levels were implemented using BioImageSuite (41,42) with the application of AFNI AlphaSim family-wise error (FWE) correction for multiple comparisons. All data analyses were based on 2-tailed tests.…”

Section: Figurementioning

confidence: 99%

Circulating glucose levels modulate neural control of desire for high-calorie foods in humans

Seo²,

et al. 2011

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Obesity is a worldwide epidemic resulting in part from the ubiquity of high-calorie foods and food images. Whether obese and nonobese individuals regulate their desire to consume high-calorie foods differently is not clear. We set out to investigate the hypothesis that circulating levels of glucose, the primary fuel source for the brain, influence brain regions that regulate the motivation to consume high-calorie foods. Using functional MRI (fMRI) combined with a stepped hyperinsulinemic euglycemic-hypoglycemic clamp and behavioral measures of interest in food, we have shown here that mild hypoglycemia preferentially activates limbic-striatal brain regions in response to food cues to produce a greater desire for high-calorie foods. In contrast, euglycemia preferentially activated the medial prefrontal cortex and resulted in less interest in food stimuli. Indeed, higher circulating glucose levels predicted greater medial prefrontal cortex activation, and this response was absent in obese subjects. These findings demonstrate that circulating glucose modulates neural stimulatory and inhibitory control over food motivation and suggest that this glucose-linked restraining influence is lost in obesity. Strategies that temper postprandial reductions in glucose levels might reduce the risk of overeating, particularly in environments inundated with visual cues of high-calorie foods. IntroductionGlucose is an important regulatory signal and the primary fuel source for the brain (1). Specialized glucose-sensing neurons located in the hypothalamus, hindbrain, and forebrain are important in the control of glucose homeostasis and feeding behavior (1, 2). Transient declines in blood glucose increase hunger and therefore mobilize an individual toward food consumption (3, 4), particularly high-sugar (5) and high-fat foods (6). Further, hypoglycemia provokes a physiological stress response to mobilize the individual toward seeking food and restoring glucose levels (6). While the role of hindbrain and hypothalamic neuronal responses in hypoglycemia and maintaining energy homeostasis is well characterized (1, 2, 7), the specific neural mechanisms mediating the motivational drive for food under mild hypoglycemic conditions are not known. We hypothesized that a reduction in circulating glucose, to levels commonly observed several hours after glucose ingestion in healthy individuals (8), would activate brain reward and motivation pathways, including the striatum and insula, while concomitantly increasing desire for high-calorie foods.To test this hypothesis, we performed functional MRI (fMRI) studies in 14 healthy (9 nonobese and 5 obese) subjects 2 hours after ingestion of a standardized lunch. Subjects viewed high-calorie food, low-calorie food, and non-food images while lying in the scanner during a stepped hyperinsulinemic euglycemic-hypo-

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Geometric strategies for neuroanatomic analysis from MRI

Cited by 102 publications

References 66 publications

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

Spatial-temporal functional mapping of language at the bedside with electrocorticography

Circulating glucose levels modulate neural control of desire for high-calorie foods in humans

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