A torti-rational knot, denoted by K(2α, β|r), is a knot obtained from the 2-bridge link B(2α, β) by applying Dehn twists an arbitrary number of times, r, along one component of B(2α, β). We determine the genus of K(2α, β|r) and solve a question of when K(2α, β|r) is fibered. In most cases, the Alexander polynomials determine the genus and fiberedness of these knots. We develop both algebraic and geometric techniques to describe the genus and fiberedness by means of continued fraction expansions of β/2α. Then, we explicitly construct minimal genus Seifert surfaces. As an application, we solve the same question for the satellite knots of tunnel number one.