Geometrical analysis of extrusion based (Additively Manufactured) 3D designed scaffold for bone tissue Engineering: A finite element approach

Bagwan, J.K.; Ahuja, B. B.; Mulay, A. V.; Jawale, Kishore

doi:10.1016/j.matpr.2021.09.049

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…The extrusion process of based HA+β-tricalcium phosphate (β-TCP) scaffolds was simulated by Bagwan et al [43], and in the work of Elsayed et al [44], borosilicate glass was used and scaffolds were printed using both DLP and direct ink writing (DIW). This last procedure allowed the gyroid scaffolds to achieve the highest compressive strength.…”

Section: Additive Manufacturingmentioning

confidence: 99%

Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects

2023

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Cellular materials have a wide range of applications, including structural optimization and biomedical applications. Due to their porous topology, which promotes cell adhesion and proliferation, cellular materials are particularly suited for tissue engineering and the development of new structural solutions for biomechanical applications. Furthermore, cellular materials can be effective in adjusting mechanical properties, which is especially important in the design of implants where low stiffness and high strength are required to avoid stress shielding and promote bone growth. The mechanical response of such scaffolds can be improved further by employing functional gradients of the scaffold’s porosity and other approaches, including traditional structural optimization frameworks; modified algorithms; bio-inspired phenomena; and artificial intelligence via machine learning (or deep learning). Multiscale tools are also useful in the topological design of said materials. This paper provides a state-of-the-art review of the aforementioned techniques, aiming to identify current and future trends in orthopedic biomechanics research, specifically implant and scaffold design.

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Section: Additive Manufacturingmentioning

confidence: 99%

Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects

2023

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“…[ 38 ] PLA 0/90 60 300 6.289 ± 0.115 230.44 ± 11.2 0/45/135/90 6.261 ± 0.097 159.19 ± 6.8 0/60/120 6.253 ± 0.134 202.2 ± 9.5 0/90 shifted 4.418 ± 0.086 156.56 ± 7.3 0/45/135/90 shifted 6.151 ± 0.126 177.62 ± 8.3 0/60/120 shifted 6.427 ± 0.144 179.5 ± 8.1 Bagwan et al. [ 39 ] PLA 0/-90/-0/-90 41.32 350 NA 21,871 to 30,948 0/-30/-0/-30 42.69 350 0/-45/-0/-45 42.25 350 0/-60/-0/-60 42.70 350 0/-45/-90/-135 42.15 350 0/-60/-120/-180 42.74 350 0/- 90/-0/- 90 47.83 514 20,340 to 28,781 0/- 30/- 0/- 30 49.14 514 0/- 45/- 0/- 45 48.92 514 0/-60/-0/-60 49.10 514 0/-45/-90/-135 50.53 514 0/60/-120/-180 49.47 514 0/-90/-0/-90 …”

Section: The Design Architecture Bone Scaffoldmentioning

confidence: 99%

“…The large discrepancy between the Young' modulus 0/90 (230.44 MPa) and the 0/90 (156.56 MPa) modulus demonstrates the substantial influence of scaffold geometry on mechanical properties. Bagwan and colleagues [ 39 ] Scaffolds with varying material compositions, layer orientations, and pore sizes are built as an input parameter for previously unexplored scaffold structures employing extrusion-based additive manufacturing. In all combinations, the scaffold with the 0-90-0-90 orientation layer has Young’s modulus comparable to actual human bone.…”

Section: The Design Architecture Bone Scaffoldmentioning

confidence: 99%

Application of fused deposition modeling (FDM) on bone scaffold manufacturing process: A review

Winarso

Anggoro

Ismail

et al. 2022

Heliyon

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“…The simulation was conducted for scaffolds with different layer orientations and pore sizes. The 0°–90°–0°–90° strand arrangement with a 350 μm pore size resulted in the optimal porosity of 41.32% and Young’s modulus of 30.948 GPa . Sun et al compared the performance of circular (10 mm diameter) and rectangular (3 × 4) shaped scaffolds with layers stacked vertically and inclined using a finite element simulation.…”

Section: Optimization Using Finite Element Analysismentioning

confidence: 99%

“…The 0°−90°−0°−90°strand arrangement with a 350 μm pore size resulted in the optimal porosity of 41.32% and Young's modulus of 30.948 GPa. 200 Sun et al compared the performance of circular (10 mm diameter) and rectangular (3 × 4) shaped scaffolds with layers stacked vertically and inclined using a finite element simulation. The circular-shaped scaffolds performed better than rectangular-shaped scaffolds in both biomechanical and biocompatibility simulations.…”

Section: Optimization Using Finite Element Analysismentioning

confidence: 99%

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

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Geometrical analysis of extrusion based (Additively Manufactured) 3D designed scaffold for bone tissue Engineering: A finite element approach

Cited by 11 publications

References 28 publications

Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects

Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects

Application of fused deposition modeling (FDM) on bone scaffold manufacturing process: A review

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

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