Geometrical structures, thermal stability and antimicrobial activity of Schiff base supramolecular and its metal complexes

El‐Sonbati, A.Z.; Diab, M.A.; El-Bindary, A.A.; Mohamed, Gehad G.; Morgan, Sh.M.; Abou‐Dobara, M. I.; Nozha, S.G.

doi:10.1016/j.molliq.2015.12.006

Cited by 45 publications

(24 citation statements)

References 48 publications

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“…The thermodynamics parameters obtained with the Coast‐Redfern and Horowitz‐Metzger methods for of HL and its polymer complexes (1–5) are listed in Table (Figures and ). The thermodynamics parameters data obtained from the two methods of Coast‐Redfern and Horowitz‐Metzger methods are comparable and can be considered in good agreement with each other . The data obtained are summarized in the following: The values of ΔG * for HL and its polymer complexes are positive values and confirmed the process is non‐spontaneous. The values of ΔS * for HL and its polymer complexes are negative values indicate the reaction is slow or more ordered activated polymer complex than the reactants …”

Section: Resultssupporting

confidence: 66%

“…The thermodynamics parameters data obtained from the two methods of Coast‐Redfern and Horowitz‐Metzger methods are comparable and can be considered in good agreement with each other . The data obtained are summarized in the following: The values of ΔG * for HL and its polymer complexes are positive values and confirmed the process is non‐spontaneous. The values of ΔS * for HL and its polymer complexes are negative values indicate the reaction is slow or more ordered activated polymer complex than the reactants The value of the thermal activation energy of decomposition (E a ) for the HL is the highest than the polymer complexes. The E a value of Ni(II) polymer complex (2) is higher than the E a value of Co(II) polymer complex (1) …”

Section: Resultssupporting

confidence: 61%

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Polymer complexes. LXXI. Spectroscopic studies, thermal properties, DNA binding and antimicrobial activity of polymer complexes

Diab

El‐Sonbati

Morgan³

et al. 2018

Applied Organom Chemis

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Polymer complexes of Co(II), Ni(II), Mn(II), Cr(III) and Cd(II) were prepared by the reaction of 3‐allyl‐5‐[(4‐nitrophenylazo)]‐2‐thioxothiazolidine‐4‐one (HL) with metal ions. The structure of polymer complexes was characterized by elemental analysis, IR, UV–Vis spectra, X‐ray diffraction analysis, magnetic susceptibility, conductivity measurements and thermal analysis. Reaction of HL with Co(II), Ni(II), Mn(II), Cr(III) and Cd(II) ions (acetate or chloride) give polymer complexes (1–5) with general stoichiometric [M(L)(O2CCH3)(H2O)2]n (where L = anionic of HL and M = Co(II) (1) or Ni(II) (2)), [Mn(HL)2(OCOCH3)2]n (3), [Cr(L)2(Cl)(H2O)]n (4) and [Cd(HL)(O2CCH3)2]n (5). The value of HOMO–LUMO energy gap (ΔE) for forms (A‐C) of monomer (HL) is 2.529, 2.296 and 2.235 eV, respectively. According to ΔE value, compound has minimum ΔE is the more stable, so keto hydrazone form (C) is more stable than the other forms (azo keto form (A), azo enol form (B)). The interaction between HL, polymer complexes of Co(II), Ni(II), Mn(II), Cr(III) and Cd(II) with Calf thymus DNA showed hypochromism effect. The HL and its polymer complexes were tested against some bacterial and fungal species. The results showed that the Cr(III) polymer complex (4) has more antibacterial activity than HL and polymer complexes (1–3 and 5) against Bacillus subtilis, Staphylococcus aureus and Salmonella typhimurium.

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Section: Resultssupporting

confidence: 66%

Section: Resultssupporting

confidence: 61%

Polymer complexes. LXXI. Spectroscopic studies, thermal properties, DNA binding and antimicrobial activity of polymer complexes

Diab

El‐Sonbati

Morgan³

et al. 2018

Applied Organom Chemis

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“…From the TG curve of the Ni(II)-complex, it can be seen that decomposition starts at 90 ˚C and shows almost a continuous weight loss in the temperature range of 90-635 ˚C. Based on the percentage of mass losses and the DTG curve, four-step decomposition is proposed for this complex, which is similar to the decomposition pattern reported previously in the literature [43]. According to literature the azo bonds in the azo schiff base-metal complexes breakdown when the temperature is higher than 250 ˚C resulting in the endothermic peaks [44].The first decomposition step with an estimated mass loss of 2.3% within the temperature range (90-150)˚C may be attributed to the loss of H2O molecule (calcd.…”

Section: Thermal Analysissupporting

confidence: 73%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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New heterocyclic azo-schiff base dye (L2) have been synthesized from a reaction of 4-(dimethylamino)benzaldehyde with (E)-5-((1H-benzo[d]imidazol-2-yl) diazenyl) -2amine-4,6-dimethylpyridin (L1) . A new class of Ni(II), Pd(II), and Pt(IV) complexes of azo-schiff base of the type [Ni(L2)2Cl2], [Pd(L2) Cl2] , and [Pt-2amine-4,6-dimethylpyridin. Both ligand and its metal complexes were characterized by the spectroscopic and analytical methods such as mass spectral, 1 H-NMR, FT-IR, UV-Visb.,X-ray, TGA and SEM, elemental analysis, molar conductance measurements and magnetic susceptibility., spectral studies suggest the mole ratio [M:L] was [1:2] for Ni(II) and Pt(IV) metal ions, but [1:1] for Pd(II) metal ion. The structures of theses complexes were elucidated on the basis of different techniques suggest the structures of the prepared metal complexes octahedral geometry for the Ni(II) and Pt(IV) complexes and square planar geometry for the Pd(II) complex. The antibacterial activity of the ligand and prepared metal complexes was also studied against gram positive Staphylococcus aureus and gram negative bacteria Escherichia coli, the antifungal activity of the azo-schiff base and metal complexes against the fungi Alternaria. It is found that some of the complexes are quite effective against fungi Alternaria. In this study the cytotoxicity of Pd(II)-complex on human (PC3) cancer and normal cells were studied using MTT assay. Pd(II)-complex showed selective cytotoxicity against cancer cell line with IC50 = 450 μg/ml, while it was very safe on normal cells line with IC50 = 14554885 μg /ml, respectively for human cells .The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of medicine and Pharmacy against prostate cancer.

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“…The XRD patterns of mixed ligand complexes showed a crystalline nature; however, that of the Schiff base ligand showed an amorphous nature. This confirmed that the presence of metal ions changed the XRD pattern of the free Schiff base ligand …”

Section: Resultssupporting

confidence: 64%

Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base

El‐Halim

Mohamed

Anwar³

2017

Applied Organom Chemis

104

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A new Schiff base ligand (HL) was prepared via a condensation reaction of quinoline-2-carboxaldhyde with 2-aminophenol in a molar ratio of 1:1. Its transition metal mixed ligand complexes with 1,10-phenanthroline (1,10-phen) as co-ligand were also synthesized in a 1:1:1 ratio. HL and its mixed ligand complexes were characterized using elemental analysis, infrared, 1 H NMR, mass and UV-visible spectroscopies, molar conductance, magnetic measurements, solid reflectance, thermal analysis, electron spin resonance and X-ray diffraction. Molar conductance measurements showed that all complexes have an electrolytic nature, except Cd(II) complex. From elemental and spectral data, the formulae [M(L)(1,10-phen)(H 2 O)] Cl x ⋅nH 2 O (where M = Cr(III) (x = n = 2), Mn(II) and Ni(II) (x = 1, n = 2), Fe(III) (x = n = 2), Co(II), Cu(II) and Zn(II) (x = 1, n = 2)) and [Cd(L)(1,10-phen) Cl]⋅3H 2 O for the metal complexes have been proposed. The geometric structures of complexes were found to be octahedral. Powder X-ray diffraction reflected the crystalline nature of the complexes; however, the Schiff base is amorphous. HL and its mixed ligand complexes were screened against Gram-positive bacteria (Streptococcus pneumoniae and Bacillus subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). Antifungal activity was determined against Aspergillus fumigatus and Candida albicans, the data showing that most complexes had activity less than that of the Schiff base while Mn(II), Fe(III) and Ni(II) complexes showed no significant antifungal activity. The anticancer activity of HL and its metal complexes was also studied against breast and colon cell lines. The metal complexes showed IC 50 higher than that of HL, especially the Cu(II) complex which showed the highest IC 50 against breast cell line.

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Geometrical structures, thermal stability and antimicrobial activity of Schiff base supramolecular and its metal complexes

Cited by 45 publications

References 48 publications

Polymer complexes. LXXI. Spectroscopic studies, thermal properties, DNA binding and antimicrobial activity of polymer complexes

Polymer complexes. LXXI. Spectroscopic studies, thermal properties, DNA binding and antimicrobial activity of polymer complexes

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base

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