This work investigates the possibility of applying two-scale computational homogenization to rod lattice structures emerging, for instance, from additive manufacturing. The influence of the number of unit cells within the representative volume element (RVE), thus, the RVE’s size on the homogenized mechanical response is studied for occurring microscopic structural instabilities. Therein, the macro-scale, described in terms of three-dimensional continuum mechanics, is coupled to the micro-scale described by geometrically exact rods, enabling arbitrary large deformations and rotations. A special feature of the presented framework is that the rods building the lattice structures are not restricted to deform purely elastically but may deform inelastically. The mechanical response of lattice structures is investigated by applying the developed homogenization method to an exemplary lattice. Under special loads the structure reaches an instable state and may buckle. The appearance of instabilities depends on the geometric properties of the lattice’s underlying rods and the RVE’s size.