Injectors are key pieces of equipment for chemigation systems, and their hydraulic performance has a significant effect on chemigation systems and crops. In order to investigate the influence of different working parameters on hydraulic performance for a water-powered proportional injector (PI), three key parameters of inlet and injection flow rate were researched using a one-factor experimental design method. The regression equations between different factors and response variables were established through a response surface method based on one-factor experimental results. Lastly, a mathematical model of the actual injection ratio was established. Some experiments under different, randomly selected parameter combinations were carried out to verify the prediction precision of the mathematical mode. The results showed that the injection flow rate increased first within the differential pressure of 0.05 to 0.10 MPa and then tended towards stability with increasing differential pressure. The injection flow rate decreased by increasing the viscosity and the change in the injection flow rate was small enough when the viscosity was greater than 500 mPa·s. The impact factors, in order of significance, for inlet flow rate were differential pressure, viscosity of injection liquid and setting injection ratio. The impact factors, in order of significance, for injection flow rate were viscosity of injection liquid, setting injection ratio and differential pressure. The regressive model for predicting the actual injection ratio was validated using an experiment and the relative deviation between calculated value and tested value was less than 5.98%, which indicated that the mathematical model had high credibility.