Geometry of Porous Hydroxyapatite Implants Influences Osteogenesis in Baboons {Papio ursinus)

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

“…In the past decade, a large number of publications illustrated osteoinduction by diverse calcium phosphate biomaterials in the form of sintered ceramics (Yamasaki, 1990;Ripamonti, 1991;Zhang, 1991;Vargervik, 1992;Yamasaki and Sakai, 1992;Klein et al, 1994;Pollick et al, 1995;Ripamonti, 1996), cements Gosain et al, 2002;Habibovic et al, 2008a), coatings (Barrere et al, 2003;Habibovic et al, 2004), as well as coral-derived ceramics (Ripamonti, 1991;Pollick et al, 1995;Magan and Ripamonti, 1996;Ripamonti, 1996;Ripamonti et al, 2009;Ripamonti et al, 2010), in various animal models. Also composites consisting of a polymer and HA have shown to be able to induce bone formation heterotopically (Hasegawa et al, 2007;Barbieri et al, 2010).…”

“…In the family of metals, porous titanium (Ti) has shown osteoinductivity, alone Takemoto et al, 2005), coated with a thin layer of calcium phosphate (Barrere et al, 2003) or in a construct with a calcium phosphate ceramic . In contrast to the limited number of reports on osteoinduction by polymers and metals, ceramicsparticularly calcium phosphate based ones -have shown osteoinductive potential in a variety of studies: HA (Ripamonti, 1991;Vargervik, 1992;Yamasaki and Sakai, 1992;van Eeden and Ripamonti, 1994;Pollick et al, 1995;Magan and Ripamonti, 1996;Ripamonti, 1996;Yuan et al, 1999;Ripamonti et al, 2009), β-tricalcium phosphate (β-TCP) (Yuan et al, 2001a;Yuan et al, 2001e), biphasic calcium phosphate (BCP), that designates the mixture of HA and TCP (Yang et al, 1996;Gosain et al, 2002), dicalcium phosphate anhydrous (DCPA), dicalcium phosphate dihydrate (DCPD) (Habibovic et al, 2008a), carbonated apatite (Habibovic et al, 2008b), calcium pyrophosphates (CPP) (Vargervik, 1992;Toth et al, 1993) and HA/calcium carbonate (CC) mixtures (Pollick et al, 1995;Ripamonti et al, 2010). A case of osteoinductive glass ceramic has also been reported (Yuan et al, 2001b).…”

“…Whereas no de novo bone formation was formed in cylinders containing bone chips, ceramics Table 1. The highest number of studies involved dog (Yamasaki and Sakai, 1992;Toth et al, 1993;Klein et al, 1994;Pollick et al, 1995b;Ripamonti, 1996;Yang et al, 1996;Yang et al, 1997;Yuan et al, 1998;Yuan et al, 1999;de Bruijn et al, 2000;Yuan et al, 2000;Yuan et al, 2001a;Yuan et al, 2001e;Kondo et al, 2006;Yuan et al, 2006a;Yuan et al, 2006b;Nasu et al, 2009) and goat (Yang et al, 1996;Yuan et al, 2002;Barrere et al, 2003;Habibovic et al, 2004;Habibovic et al, 2005;Habibovic et al, 2006a;Habibovic et al, 2006c;Bodde et al, 2007;Habibovic et al, 2008a;Habibovic et al, 2008b;Habibovic et al, 2010); the number of published studies involving baboon (Ripamonti, 1991;Ripamonti, 1996;Magan and Ripamonti, 1996;Ripamonti et al, 1999;Ripamonti et al, 2007;Ripamonti et al, 2008;Ripamonti et al, 2009;Ripamonti et al, 2010), sheep (Gosain et al, 2002Le Nihouannen et al, 2005;Yuan et al, 2010), rabbit …”

“…After four weeks, bone formation was observed only in six out of the eight strains. Within mice from each strain, the number of individuals where bone formation was observed varied and the average amount of bone was also different (Marusic et al, 1999), showing that -even among mice of inbred strain -phenotypical differences are such that results are not only strain but also individual dependent. In the case of larger animals, genetic variability will be even higher, as these are always outbred.…”

CT-Generated Porous Hydroxyapatite Orbital Floor Prosthesis as a Prototype Bioimplant

“…Of these variables, implant pore size and pore directionality have been identified (4). Our purpose in this article is to illustrate the manufacture of an orbital floor prosthesis from a hydroxyapatite bioceramic by using medical imaging data.…”