The Wasserstein space P 2 consists of square integrable probability measures on R d and is equipped with the intrinsic Riemannian structure. By using stochastic analysis on the tangent space, we construct the Ornstein-Uhlenbeck (O-U) process on P 2 whose generator is formulated as the intrinsic Laplacian with a drift. This process satisfies the log-Sobolev inequality and has L 2 -compact Markov semigroup. Due to the important role played by O-U process in Malliavin calculus on the Wiener space, this measure-valued process should be a fundamental model to develop stochastic analysis on the Wasserstein space. Perturbations of the O-U process is also studied.