The resistivity exploration has made a great contribution to prospecting at the macro level, but the resistivity exploration at the micro level is relatively weak. In this paper, the corresponding resistivity is analyzed through a geochemical element test, temperature and pressure test, water content and porosity test, and the resistivity parameter model of the rock and ore is established based on the response surface. The main conclusions and understandings obtained are as follows: with the increase of Cu-Pb-Zn content, the rock-ore resistivity shows an obvious decreasing trend, with sphalerite resistivity (72.8×10−2 Ω·m) > pyrite resistivity (32.5×10−2 Ω·m) > galena resistivity (76.5×10−3 Ω·m) > chalcopyrite (11.3×10−3 Ω·m). The resistivity increases with the temperature, showing a quadratic term function trend increases. The resistivity decreases with the increase of pressure, decreasing rapidly at the beginning of loading and gradually slowing down. The resistivity decreases rapidly with the increase of water content and porosity in an exponential function trend. The degree of influence of four factors, temperature, pressure, porosity, and water content, on the resistivity of the ore samples, is the order of water content, porosity, pressure, and temperature. The coupled model of resistivity of Cu-Pb-Zn ores established by multivariate quadratic regression analysis is more reliable, and the predicted value of rock and ore resistivity is more consistent with the test data.