Geopropolis from Melipona scutellaris decreases the mechanical inflammatory hypernociception by inhibiting the production of IL-1β and TNF-α

Franchin, Marcelo; Cunha, Marcos Guilherme da; Denny, Carina; Napimoga, Marcelo Henrique; Cunha, Thiago M.; Koo, Hyun; Alencar, Severino Matias de; Ikegaki, Masaharu; Rosalen, Pedro Luiz

doi:10.1016/j.jep.2012.07.040

Cited by 72 publications

(58 citation statements)

References 36 publications

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“…In the in vitro study along with the antioxidant test, Massaro et al [11] reported that the anti-inflammatory mechanism in the cerumen extract in stingless bee products inhibits the 5-LOX enzyme that is responsible for the synthesis of proinflammatory mediators. Similarly, Franchin et al [84] found that the ethanolic extract of geopropolis (another name for cerumen) significantly reduces the level of proinflammatory cytokines.…”

Section: Anti-inflammatory Role Of Stingless Bee Honeymentioning

confidence: 99%

Stingless Bee Honey, the Natural Wound Healer: A Review

Jalil¹,

Kasmuri²,

Hadi³

2017

Skin Pharmacol Physiol

171

138

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Background: The stingless bee is a natural type of bee that exists in almost every continent. The honey produced by this bee has been widely used across time and space. The distinctive feature of this honey is that it is stored naturally in the pot (cerumen), thus contributing to its beneficial properties, especially in the wound healing process. Methods: In this article, several studies on stingless bee honey that pointed out the numerous therapeutic profiles of this honey in terms of its antioxidant, antimicrobial, anti-inflammatory, as well as moisturizing properties are reviewed. All of these therapeutic properties are related to wound healing properties. Results: Antioxidant in stingless bee honey could break the chain of free radicals that cause a detrimental effect to the wounded area. Furthermore, the antimicrobial properties of stingless bee honey could overcome the bacterial contamination and thus improve the healing rate. Moreover, the anti-inflammatory attribute in this honey could protect the tissue from highly toxic inflammatory mediators. The moisturizing properties of the honey could improve wound healing by promoting angiogenesis and oxygen circulation. Conclusion: The application of honey to the wound has been widely used since ancient times. As a result, it is essential to understand the pharmacological mechanism of the honey towards the physiology of the wounded skin in order to optimize the healing rate in the future.

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Section: Anti-inflammatory Role Of Stingless Bee Honeymentioning

confidence: 99%

Stingless Bee Honey, the Natural Wound Healer: A Review

Jalil¹,

Kasmuri²,

Hadi³

2017

Skin Pharmacol Physiol

171

138

View full text Add to dashboard Cite

show abstract

“…actions have been demonstrated, like antioxidant (Frozza et al, 2013), anti-nociceptive (Franchin et al, 2012), and anti-inflammatory (Búfalo et al, 2013;Szliszka et al, 2013). These activities are linked to its bioactive compounds and it is noteworthy that propolis from different geographic regions can vary significantly in its chemical composition (López et al, 2014;Piccinelli et al, 2011;Sawaya et al, 2011).…”

Section: Propolis Extracts Have Received Great Interest In Medicine Amentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Cavendish

Santos

Neto

et al. 2015

Journal of Ethnopharmacology

123

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“…The geopropolis (a mixture of resin, wax and soil) from the stingless bee Melipona scutellaris from the northeast region of Brazil decreases the production level of IL-1β and TNF-α (Franchin et al, 2012). As key parameters in inflammation responses, this suggests an anti-inflammatory role.…”

Section: Introductionmentioning

confidence: 99%

Propolis from the Stingless Bee Trigona incisa from East Kalimantan, Indonesia, Induces In Vitro Cytotoxicity and Apoptosis in Cancer Cell lines

Kustiawan

Phuwapraisirisan²,

Puthong³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Previously, stingless bee (Trigona spp.) products from East Kalimantan, Indonesia, were successfully screened for in vitro antiproliferative activity against human cancer derived cell lines. It was established that propolis from T. incisa presented the highest in vitro cytotoxicity against the SW620 colon cancer cell line (6% cell survival in 20 µg/mL). In addition, the F45 fraction induced cell cycle arrest at the G1 subphase. Conclusions: Indonesian stingless bee (T. incisa) propolis had moderately potent in vitro anticancer activity on human cancer derived cell lines. Cardol or 5-pentadecyl resorcinol was identified as a major active compound and induced apoptosis in SW620 cells in an early period (≤ 6 h) and cell cycle arrest at the G1 subphase. Thus, cardol is a potential candidate for cancer chemotherapy.

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Geopropolis from Melipona scutellaris decreases the mechanical inflammatory hypernociception by inhibiting the production of IL-1β and TNF-α

Abstract: Our data indicate that geopropolis is a natural source of bioactive substances with promising antinociceptive activity.

Cited by 72 publications

References 36 publications

Stingless Bee Honey, the Natural Wound Healer: A Review

Stingless Bee Honey, the Natural Wound Healer: A Review

Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Propolis from the Stingless Bee Trigona incisa from East Kalimantan, Indonesia, Induces In Vitro Cytotoxicity and Apoptosis in Cancer Cell lines

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