In geochemical exploration, in order to highlight the local anomalies, the background Anomaly separation is required. Most geochemical and geostatistical analysis in mining exploration requires removing regional trends in order to obtain local anomalies. In this paper, Khusf stream sediment was studied based on fractal geometry and correspondence analysis methods. This paper conducted a chemical analysis of fluvial sediments to find high-potential areas of Pb, Cd, and As elements in the Khusf area of South Iran's Khorasan province using fractal anomaly separation technique. Correspondence analysis with 170 samples through 20 elements concentration values in each sample was performed. According to correspondence analysis, among one or several elements in the study area was separated which the highest concentration relative to the variables Pb, As, and Cd elements. The correspondence analysis revealed that in the Khusf area at some locations Pb, Cd, and as elements have been accumulated anomalously. After the correspondence analysis, the best variogram for the Khusf area was obtained. Elemental concentration maps was then produced through estimating the values using kriging method. Therefore using the fractal method, between three statistical sets of elements, it was concluded that the third set showed the anomaly for Pb, Cd, and As elements. Local anomaly values are respectively determined as 55, 7.2, and 0.88 ppm. Finally, it is suggested that this region has the possibility of Basic Metals occurrence and suggests further geophysical operations on a local identification scale.