Characterizing urban expansion patterns is of great significance to planning and decision-making for urban agglomeration development. This study examined the urban expansion in the entire Yangtze River Delta Region (YRDR) with its land-use data of six years (1995, 2000, 2005, 2010, 2015, and 2018). On the basis of traditional methods, we comprehensively considered the four aspects of urban agglomeration: expansion speed, expansion difference, expansion direction, and landscape pattern, as well as the interconnection of and difference in the expansion process between each city. The spatiotemporal heterogeneity of urban expansion development in this region was investigated by using the speed and differentiation indices of urban expansion, gravity center migration, landscape indices, and spatial autocorrelations. The results show that: (1) over the 23 years, the expansion of built-up land in the Yangtze River Delta Region was significant, (2) the rapidly expanding cities were mainly located along the Yangtze River and coastal areas, while the slowly expanding cities were mainly located in the inland areas, (3) the expansion direction of each city varied and the gravity center of the urban agglomeration moved toward the southwest, and (4) the spatial structure of the region became more clustered, the shape of built-up land turned simpler, and fragmentation decreased. This study unravels the spatiotemporal change of urban expansion patterns in this large urban agglomeration, and more importantly, can serve as a guide for formulating urban agglomeration development plans.