The systematic modelling of dynamic spatial systems is a key requirement in a wide range of application areas such as commonsense cognitive robotics, computer-aided architecture design, and dynamic geographic information systems. We present ASPMT(QS), a novel approach and fully-implemented prototype for non-monotonic spatial reasoning -a crucial requirement within dynamic spatial systems-based on Answer Set Programming Modulo Theories (ASPMT).ASPMT(QS) consists of a (qualitative) spatial representation module (QS) and a method for turning tight ASPMT instances into Satisfiability Modulo Theories (SMT) instances in order to compute stable models by means of SMT solvers. We formalise and implement concepts of default spatial reasoning and spatial frame axioms. Spatial reasoning is performed by encoding spatial relations as systems of polynomial constraints, and solving via SMT with the theory of real nonlinear arithmetic. We empirically evaluate ASPMT(QS) in comparison with other contemporary spatial reasoning systems both within and outside the context of logic programming. ASPMT(QS) is currently the only existing system that is capable of reasoning about indirect spatial effects (i.e., addressing the ramification problem), and integrating geometric and qualitative spatial information within a non-monotonic spatial reasoning context. This paper is under consideration for publication in TPLP.KEYWORDS: non-monotonic spatial reasoning; answer set programming modulo theories; declarative spatial reasoning; dynamic spatial systems; reasoning about space, actions, and change * This is an extended version of a paper presented at the Logic Programming and Nonmonotonic Reasoning Conference (LPNMR 2015), invited as a rapid communication in TPLP. The authors acknowledge the assistance of the conference program chairs Giovambattista Ianni and Miroslaw Truszczynski. † This paper comes with an online appendix containing Appendices A-H. The online appendix is available via the supplementary materials link from the TPLP web-site.