GEPT Extract Reduces A&amp;#946; Deposition by Regulating the Balance Between Production and Degradation of A&amp;#946; in APPV717I Transgenic Mice

Tian, Jinzhou; Shi, Jing; Zhang, Leiming; Yin, Jun; Hu, Quan; Xu, Yi; Shen, Sheng; Wang, Pengwen; Ren, Ying; Wang, Rong; Wang, Yongyan

doi:10.2174/156720509787602942

Cited by 25 publications

(29 citation statements)

References 38 publications

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“…In addition, the dosage of Aricept in this study was 0.65 mg/ kg/day, which is much less than other studies (0.92 mg/kg/ Yang et al The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment 1015 day). 17,18,32 Furthermore, clinical studies have shown that cognitive effects are better at a higher concentration of Aricept (23 mg/day) compared with a lower concentration (5 mg/day or 10 mg/day). 33 Therefore, we suspect that the lack of effect of Aricept on the early treatment strategy was due to its dosage.…”

Section: Discussionmentioning

confidence: 99%

The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment

Yang

Tan

Wang

et al. 2014

Exp Biol Med (Maywood)

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In China, herbal medicine has an extensive history for the treatment of cerebrovascular diseases. Clinical studies have shown that stroke patients are more likely to experience significant memory decline in comparison to their healthy counterparts. Cognition is improved in stroke patients treated with herbal medicine active components, Geniposide (GP) and Geniposide Rg1 (GRg1) (together, called TLJN). However, the effect of TLJN in Alzheimer disease remains unknown. Therefore, we investigated the behavioral effect of TLJN in male and female APP/V717I transgenic (Tg) mice. We conducted two different treatment strategies: (1) pretreatment strategy: medically treated at the age of 3 months which lasted for 3 months; (2) early treatment strategy: medically treated at the age of 6 months which lasted for 4 months. In open field test, locomotor activity and anxiety-like behavior were not affected after TLJN administration in Tg mice. In Morris Water Maze test, spatial learning processes in both genders were improved by TLJN treatments. Furthermore, retrieval processes were significantly improved in the pretreatment strategy for only male mice, which also showed a trend for improved retrieval processes with early treatment. In the inhibitory avoidance test, TLJN enhanced learning processes. In addition, gender differences were found in Tg mice exposed to TLJN treatments. In Tg male mice, significant efficacy was seen at high and middle doses, and in Tg female mice, a low dose was more effective.

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Section: Discussionmentioning

confidence: 99%

The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment

Yang

Tan

Wang

et al. 2014

Exp Biol Med (Maywood)

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“…GEPT, a combination of five active components extracted from Chinese herbs, may be valuable for the treatment of AD - reducing the level of Aβ via the inhibition of γ-secretase (presenilin-1) and the promotion of insulin-degrading enzyme and neprilysin, which has been reported in the brain of APPV717I transgenic mice [13]. A 24-week preliminary study of GEPT showed a significant improvement on cognitive function in patients with amnestic mild cognitive impairment, an early stage of AD ( n = 101), consistently across different cognitive scales; for example, an improvement in the ADAS cognitive subscale from baseline of -4.19 points (95% confidence interval = -5.74 to -2.63), which declined at 24 weeks of follow-up after the GEPT withdrawal.…”

Section: Herbal Formulations or Mixtures Of Herbal Ingredientsmentioning

confidence: 99%

Herbal therapy: a new pathway for the treatment of Alzheimer's disease

Tian

Shi

Zhang

et al. 2010

Alzheimer's Research & Therapy

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It has been a clinical challenge to treat Alzheimer's disease (AD). In the present commentary we discuss whether herbal therapy could be a novel treatment method for AD on the basis of results from clinical trials, and discuss the implications for potential therapy for AD pathophysiology. There is evidence to suggest that single herbs or herbal formulations may offer certain complementary cognitive benefits to the approved drugs. The current evidence supporting their use alone, however, is inconclusive or inadequate owing to many methodological limitations. Herbal mixtures may have advantages with multiple target regulation compared with the single-target antagonist in the view of traditional Chinese medicine. Several clinical trials using herbal mixtures are being conducted in China and will hopefully show promising results for treating AD in the near future.

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“…This opens the possibility of the use of mimetic A -like peptides to induce NEP expression. Other types of pharmacologic induction are also being explored [116][117][118]. These studies outline the various strategies by which NEP augmentation can be developed therapeutically.…”

Section: Neprilysin Therapymentioning

confidence: 99%

Diabetes NEP-Like Endopeptidases and Alzheimers Disease

Marr¹,

Spencer²

2010

CAR

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The accumulation of the amyloid-beta peptide (Abeta) continues to emerge as a central factor in Alzheimer's disease (AD). In recent years attention has been drawn to clearance mechanisms of Abeta as evidence suggests reduced clearance may be linked to late-onset AD. Direct degradation of Abeta by endopeptidases has emerged as one critical pathway of clearance. Of particular interest are endopeptidases that are sensitive to the neprilysin inhibitors thiorphan and phosphoramidon (i.e. "NEP-like") as these inhibitors induce a dramatic increase in Abeta levels resulting in rapid plaque formation in wild-type rodents. This review focuses on neprilysin (NEP) and on another NEP-like endopeptidase termed neprilysin-2 (NEP2). The involvement of these endopeptidases in AD and the state of their therapeutic development are discussed.

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GEPT Extract Reduces Aβ Deposition by Regulating the Balance Between Production and Degradation of Aβ in APPV717I Transgenic Mice

Cited by 25 publications

References 38 publications

The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment

The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment

Herbal therapy: a new pathway for the treatment of Alzheimer's disease

Diabetes NEP-Like Endopeptidases and Alzheimers Disease

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