GERD: The Potential for Endoscopic Intervention

Triadafilopoulos, George

doi:10.1159/000080317

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…(5) In USA, 7-15% of western population has GERD, which is the 3 rd most common GI disorder. (6) There is limited data from Asia including India. 24 hour ambulatory esophageal pH monitoring and esophageal manometry are diagnostic of GERD without evidence of esophagitis.…”

Section: Discussionmentioning

confidence: 99%

Severe Bronchial asthma induced by Gastro esophageal reflux disease – a case report

2017

AGEMS

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Gastroesophageal events remain an important factor in the pathogenesis of patients with asthma with the reported prevalance ranging from 32-82%. The esophageal bronchial reflux plays a greater role in the pathophysiology of reflex associated cough. Gastroesophageal reflux either singly or in association with postnasal drip and or asthma is a thought to be a cause of chronic cough. People with asthma are twice as likely to have GERD as those people who don't have asthma. GERD may worsen asthma symptoms, however asthma and some asthma medications may worsen GERD symptoms. Although these two disorders often occur together, the relationship between GERD and asthma remains unclear.

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Section: Discussionmentioning

confidence: 99%

Severe Bronchial asthma induced by Gastro esophageal reflux disease – a case report

2017

AGEMS

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“…However, a significant percentage of patients with GERD may experience extraesophageal manifestations such as asthma, laryngitis, excessive throat phlegm, and chronic cough [1].…”

Section: Discussionmentioning

confidence: 99%

The Laparoscopic Nissen Fundoplication Eliminates Obstructive Sleep Apnea Syndrome Due to Gastroesophageal Reflux Disease

Zhang

Wang

Wu³

et al. 2012

Indian J Surg

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Gastroesophageal reflux disease may produce esophageal syndromes, such as heartburn and regurgitation. It is a common clinical presentation with extraesophageal manifestations, such as asthma, arrhythmia, snoring, and sleep disturbance, which could make identifying it more difficult than the usual esophageal symptoms. The aim of this study is to characterize the extraesophageal manifestations in patients with gastroesophageal reflux disease and investigate the effect of laparoscopic Nissen fundoplication. We describe the case of a 38-year-old male patient with a history of sleep disturbance attributable to gastroesophageal reflux disease, which resolved on successful laparoscopic Nissen fundoplication treatment. The long-standing sleep apnea obviously improved after laparoscopic Nissen fundoplication treatment. To our knowledge, this is a rare case of successful laparoscopic Nissen fundoplication treatment of a patient with extraesophageal manifestations induced by gastroesophageal reflux disease. The results indicate an underlying mechanism for extraesophageal manifestations and the success of laparoscopic Nissen fundoplication treatment.Keywords Laparoscopic Nissen fundoplication . Obstructive sleep apnea syndrome . Gastroesophageal reflux disease Case ReportWe report the case of a 38-year-old male patient who had been experiencing acid reflux and heartburn for 10 years, as well as attacks of shortness of breath, stridor, and laryngeal tightness for 6 years. He was otherwise healthy and had no history of smoking, drinking, allergies, or family history of any similar diseases. He received six emergency rescue treatments from a local hospital due to suffocation. We found edema of the throat and laryngospasm when we did incision of trachea at the updated emergency rescue.Laboratory examinations, heart ultrasound, and chest X-ray yielded no abnormalities. Gastroscopy presented reflux esophagitis with Los Angeles grade C and Barrett esophagus. The Helicobacter pylori culture was positive. The Demesster score of 24-hour esophageal pH monitoring was 78.34. It showed severe pathological acid reflux in the distal esophagus. Esophageal manometry indicated that the pressure of lower esophageal sphincter was low. Polysomnography (PSG) found severe nocturnal anoxemia. The patient's apnea hypopnea index (AHI) was 45.7 and the min SpO 2 was 57 %.The patient was diagnosed with gastroesophageal reflux disease (GERD), reflux esophagitis with LA-C, H. pylori (+), Barrett esophagus, and obstructive sleep apnea syndrome (OSAS). He was treated with drugs for GERD, including domperidone, famotidine, and omeprazole. After the chemotherapy, the symptoms, including acid reflux and heartburn, were relieved. However, there were no obvious changes in symptoms such as the attacks of shortness of breath, stridor, laryngeal tightness, and sleep apnea. The repeat PSG found that AHI was 40 and the min SpO 2 was 55 %.

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“…Its extraesophageal manifestations, such as asthma, paroxysmal laryngospasm, and excessive throat phlegm, chronic cough, laryngal disorders, postnasal drip and other lesser ear, nose and throat symptoms, have been reported [1]. Thus, GERD patients with complications of respiratory distress are considered an integral aspect of the syndrome in the Western world.…”

Section: Discussionmentioning

confidence: 99%

“…A high prevalence of GERD in asthma patients has been reported in the Western world [1,[7][8][9]. For instance, in the United States, GERD is the third most common GI disorder, after infectious diarrhea and gallstones [5].…”

Section: Discussionmentioning

confidence: 99%

Not asthma, but GERD: case report

Wang

2007

Front. Med. China

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Asthma is a disorder of the lungs characterized by increased responsiveness of the airways, as manifested by episodes of wheezing and increased resistance to expiratory airflow because of varying degrees of smooth muscle contraction, edema of the mucosa, and mucus in the lumen of the bronchi and bronchioles. The stimuli vary widely and include antigens, infection, air pollutants, respiratory tract irrtants, exercise, and emotional factors. This condition is completely different from distress breathing because of laryngotracheal spasm. One of its causes is the gastric content reflux through the pharynx to the larynx because of gastroesophageal reflux disease (GERD), in addition to the typical human avian flu that may cause immediate suffocation by laryngospasm owing to acute larygotrachitis. A patient suffered from GERD without esophageal symptoms, which was diagnosed and treated as bronchial asthma during his five emergency admissions. The admissions were because of episodic attacks of severe air hunger owing to an extreme throat tightening. The patient was being treated for as long as two years. After the correct diagnosis was made and treatment of laporascopic fundaplication was performed, the longstanding "bronchial asthma", after all, completely disappeared. The concept of "not asthma, but GERD" seems undervalued, unappreciated, even misunderstood among patients with intractable asthma. Therefore, such a case is reported in detail, similar cases are mentioned briefly as well, and a mechanism responsible for GERD-originated larryngo-or laryngotracho-spasm is proposed.

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GERD: The Potential for Endoscopic Intervention

Cited by 11 publications

References 32 publications

Severe Bronchial asthma induced by Gastro esophageal reflux disease – a case report

Severe Bronchial asthma induced by Gastro esophageal reflux disease – a case report

The Laparoscopic Nissen Fundoplication Eliminates Obstructive Sleep Apnea Syndrome Due to Gastroesophageal Reflux Disease

Not asthma, but GERD: case report

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