Geriatric assessment-identified impairments and frailty in adults with cancer younger than 65: An opportunity to optimize oncology care

Pergolotti, Mackenzi; Wood, Kelley C.; Hidde, Mary; Kendig, Tiffany D.; Ronnen, Ellen A.; Giri, Smith; Williams, Grant R.

doi:10.1016/j.jgo.2024.101751

Journal of Geriatric Oncology

2024

DOI: 10.1016/j.jgo.2024.101751

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Geriatric assessment-identified impairments and frailty in adults with cancer younger than 65: An opportunity to optimize oncology care

Mackenzi Pergolotti,

Kelley C. Wood,

Mary Hidde

et al.

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2024

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Cited by 2 publications

References 52 publications

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Pain and Frailty in Childhood Cancer Survivors: A Narrative Review

Papini,

Sodhi,

Argenbright

et al. 2024

Current Oncology

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A significant proportion of childhood cancer survivors experience persistent health problems related to cancer or cancer treatment exposures, including accelerated or early onset of aging. Survivors are more likely than non-cancer peers to present a frail phenotype suggestive of reduced physiologic reserve and have symptoms that interfere with function in daily life, including pain. Studies in the general population, mostly among older adults, suggest that pain is a significant contributor to development and progression of frail health. This association has not been explored among childhood cancer survivors. In this narrative review, we highlight this gap by summarizing the epidemiologic evidence on pain and frailty, including their prevalence, common risk factors, and correlates in childhood cancer survivors. We further discuss associations between pain and frailty in non-cancer populations, likely biological mechanisms in survivors, and potential interventions targeting both domains.

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Pain and Frailty in Childhood Cancer Survivors: A Narrative Review

Papini,

Sodhi,

Argenbright

et al. 2024

Current Oncology

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Hematological Malignancies in Older Patients: Focus on the Potential Role of a Geriatric Assessment Management

Caserta,

Cancemi,

Loreta

et al. 2024

Diagnostics

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Geriatric assessment management is a multidimensional tool used to evaluate prognosis for clinical outcomes and targets for interventions in older adults with cancer receiving chemotherapy. In this review, we evaluated the possible application of geriatric assessment management (GAM) in hematological malignancies. In older patients with Diffuse Large B Cell Lymphoma, GAM might be helpful in both predicting planned hospital admissions and improving quality of life. In chronic myeloid leukemia, the Charlson Comorbidity Index demonstrates how comorbidities could affect treatment compliance and overall outcomes. In multiple myeloma, the application of different scores such as the International Myeloma Working Group Frailty Index and the Revised Myeloma Comorbidity Index can identify frail patients who need suitable interventions in treatment plan (reducing drug dose or changing treatment). Therefore, including GAM in the management plan of older patients with hematological malignancies may direct and optimize cancer care.

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Geriatric assessment-identified impairments and frailty in adults with cancer younger than 65: An opportunity to optimize oncology care

Cited by 2 publications

References 52 publications

Pain and Frailty in Childhood Cancer Survivors: A Narrative Review

Pain and Frailty in Childhood Cancer Survivors: A Narrative Review

Hematological Malignancies in Older Patients: Focus on the Potential Role of a Geriatric Assessment Management

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