Geriatric Depression Scale

Galik, Elizabeth; Fukudo, Shin; Tanaka, Yukari; Pellowski, Jennifer; García, Luis I.; Mitchell, Jason W.; Erausquin, Jennifer Toller; Chiba‐Falek, Ornit; Jiang, Rong; Campbell, Tavis S.; Johnson, Jillian A.; Zernicke, Kristin A.; Turner, J. Rick; Turner, J. Rick; LeRoy, Bonnie S.; O’Daniel, Julianne; Turner, J. Rick; Pereira, Deidre; Sannes, Timothy S.; Simonson, Matthew A.; McCarthy, Jeanette; Turner, J. Rick; Rodríguez-Murillo, Laura; Salem, Rany M.; Jones, Phil; Molton, Ivan; Ghaemmaghami, Pearl; Ehlert, Ulrike; Takimoto, Yoshiyuki; Al’Absi, Mustafa; Sanchez, Janine; Coons, Michael James; Meneghini, Luigi; Morizio, Alexandre; Bacon, Simon; Oyebode, Jan R.; Gidron, Yori; Cumming, Jennifer; Anderson, Giles M.

doi:10.1007/978-1-4419-1005-9_194

Cited by 2 publications

(2 citation statements)

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“…MDs were diagnosed according to ICD-10 criteria [ 50 ] and evaluated in an interview and with standardized questionnaires. MD patients had to score at least 6 points on the Geriatric Depression Scale [ 51 ], 10 or more points on the Becks Depression Inventory [ 52 ], or at least 13 points on the Becks Depression Inventory-II [ 53 ]. The study was approved by the local ethics committee and performed in compliance with relevant laws and institutional guidelines.…”

Section: Methodsmentioning

confidence: 99%

Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex

et al. 2023

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Objective: Evaluation of interrater reliability for manual segmentation of brain structures that are affected first by neurofibrillary tau pathology in Alzheimer’s disease. Method: Medial perirhinal cortex, lateral perirhinal cortex, and entorhinal cortex were manually segmented by two raters on structural magnetic resonance images of 44 adults (20 men; mean age = 69.2 ± 10.4 years). Intraclass correlation coefficients (ICC) of cortical thickness and volumes were calculated. Results: Very high ICC values of manual segmentation for the cortical thickness of all regions (0.953–0.986) and consistently lower ICC values for volume estimates of the medial and lateral perirhinal cortex (0.705–0.874). Conclusions: The applied manual segmentation protocol allows different raters to achieve remarkably similar cortical thickness estimates for regions of the parahippocampal gyrus. In addition, the results suggest a preference for cortical thickness over volume as a reliable measure of atrophy, especially for regions affected by collateral sulcus variability (i.e., medial and lateral perirhinal cortex). The results provide a basis for future automated segmentation and collection of normative data.

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Section: Methodsmentioning

confidence: 99%

Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex

et al. 2023

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“…ALZHEIMER'S DISEASE-NOVEL ODDITY DETECTION TASK Twenty-six participants were diagnosed with MD, including 14 participants recruited from the Memory Clinic FELIX PLATTER and 12 recruited from the University Psychiatric Clinics Basel, Switzerland. MD patients had to score 6 or more points on the Geriatric Depression Scale (Galik et al, 2013), 10 or more points on the Becks Depression Inventory (Beck et al, 1961), or 13 or more on Becks Depression Inventory-II (Beck et al, 2011).…”

Section: Participantsmentioning

confidence: 99%

Can you find it? Novel oddity detection task for the early detection of Alzheimer’s disease.

Frei¹,

Berres²,

Kivisaari³

et al. 2023

Neuropsychology

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Objective: We aimed to develop a measure to specifically assess the functioning of the perirhinal cortex (PRC), a brain structure affected very early in Alzheimer's disease (AD) pathology. In this novel task, participants were shown arrays of six complex figures and had to identify the "odd-one." Method: The pilot study included 50 normal controls (NCs) and 50 patients in very early stages of AD. Participants completed the task and received MRI scanning. Best differentiating items were determined and applied in a validation study including 25 NCs, 27 early-stage AD patients, and 26 patients with major depression. Logistic regression models investigated if task performance predicted group membership. Task performance was then related to whole-brain gray matter integrity. As proof of concept, cortical thickness values of four regions of interest (ROIs; e.g., medial PRC and entorhinal cortex [ERC]) were compared between the groups. The associations of task performance and cortical thickness of the ROIs were investigated using linear models. Results: Task performance showed good discriminative ability between early-stage AD patients and NCs. Whole-brain analyses revealed four significant clusters ( p < .001) with peak voxels in parahippocampal regions including PRC and ERC. ROI analyses showed distinctly reduced cortical thickness in the AD group compared to both other groups in the medial PRC and ERC ( p ≤ .001). Task performance modeled by ROI cortical thickness did not achieve significant results. Conclusion: Although further validation is needed, especially with age-matched participant groups, these findings indicate that the task detects early cognitive impairment related to AD. Neuropsychology

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Geriatric Depression Scale

Cited by 2 publications

References 0 publications

Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex

Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex

Can you find it? Novel oddity detection task for the early detection of Alzheimer’s disease.

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