Geriatric nutritional risk index as a predictor for postoperative complications in patients with solid cancers: a meta-analysis

Liu, Weichen; Li, Ming; Lian, Siqin; Hou, Xijie; Ling, Ying

doi:10.3389/fonc.2024.1266291

Cited by 3 publications

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Significance of the geriatric nutritional risk index and neutrophil-to-lymphocyte ratio as prognostic indicators in older patients with gastric cancer: a retrospective cohort study

Miyamoto,

Toyokawa,

Ishidate

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Background The number of older patients with cancer is increasing with the progression of aging societies. In the current study, we sought to clarify the prognostic values of the geriatric nutritional risk index (GNRI) as a nutritional index and the neutrophil-to-lymphocyte ratio (NLR) as an inflammatory index in older patients with gastric cancer. Methods Between January 2007 and December 2016, a total of 197 consecutive gastric cancer patients aged ≥ 75 years who underwent radical gastrectomy were enrolled in this study. The prognostic values of preoperative GNRI and NLR were assessed using time-dependent receiver operating characteristic curve analysis, log-rank tests, and Cox regression analysis. Results The areas under the curve (AUCs) predicting 5-year overall survival (OS) were 0.668 for GNRI and 0.637 for NLR. The 5-year OS rates in the groups with low GNRI and NLR were 40.1% and 74.1% ( p < 0.001), and those with high GNRI and NLR were 70.7% and 41.5% ( p < 0.001), respectively. Multivariate analysis showed that GNRI (hazard ratio (HR): 0.584; 95% confidence interval (CI): 0.356–0.960; p = 0.034) and NLR (HR: 2.470; 95% CI: 1.503–4.059; p < 0.001) were independent predictors for OS. The GNRI–NLR score constructed with GNRI and NLR had a higher AUC (0.698) than those of GNRI or NLR alone and was an independent prognostic factor (HR, 0.486; 95% CI: 0.363–0.651; p < 0.001). Conclusions GNRI and NLR are useful prognostic biomarkers in older patients with gastric cancer aged ≥ 75 years. The GNRI–NLR score could contribute to a more personalized and holistic approach to cancer treatment in this patient population.

show abstract

Significance of the geriatric nutritional risk index and neutrophil-to-lymphocyte ratio as prognostic indicators in older patients with gastric cancer: a retrospective cohort study

Miyamoto,

Toyokawa,

Ishidate

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

show abstract

Significance of geriatric nutritional risk index and neutrophil-to-lymphocyte ratio as prognostic indicators in older patients with gastric cancer: A retrospective cohort study

Miyamoto,

Toyokawa,

Ishidate

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The number of older patients with cancer is increasing with the progression of aging societies. We aimed to clarify the prognostic values of the geriatric nutritional risk index (GNRI) as a nutritional index and the neutrophil-to-lymphocyte ratio (NLR) as an inflammatory index in older patients with gastric cancer. Methods: Between January 2007 and December 2016, a total of 197 consecutive gastric cancer patients aged ≥75 years who underwent radical gastrectomy were included in this study. We evaluated the prognostic values of preoperative GNRI and NLR using time-dependent receiver operating characteristic curveanalysis, log-rank tests and Cox regression analysis. Results: The areas under the curve (AUCs) predicting 5-year OS were 0.668 for GNRI and 0.637 for NLR. The 5-year OS rates in the groups with low and high GNRI and NLR were 40.1% and 74.1% (p<0.001), 70.7% and 41.5% (p<0.001), respectively. Multivariate analysis showed that GNRI (Hazard ratio (HR): 0.584; 95% confidence interval (CI): 0.356–0.960; p=0.034) and NLR (HR: 2.470; 95% CI: 1.503–4.059; p<0.001) were independent predictors for OS. GNRI-NLR score constructed with GNRI and NLR had a higher AUC of 0.698 than those of either GNRI or NLR alone, and was an independent prognostic factor (HR, 0.486; 95% CI: 0.363–0.651; p<0.001). Conclusions: GNRI and NLR are useful prognostic biomarkers in older gastric cancer patients aged ³75years, and the GNRI-NLR score could contribute to a more personalized and holistic approach to cancer treatment in older gastric cancer patients.

show abstract

Prognostic Factors for Mortality in Patients Aged 90 Years and Older with Proximal Femoral Fractures Undergoing Surgery: A Retrospective Study

Yokoo,

Shiota,

Sato

et al. 2024

JCM

View full text Add to dashboard Cite

Background/Objectives: Proximal femoral fractures (PFFs) among individuals aged ≥90 years are becoming more common with an aging population and are associated with high morbidity and mortality. This study analyzed the prognostic factors influencing survival in nonagenarian patients undergoing surgery for PFFs. Methods: We enrolled 285 patients who underwent surgery between 2016 and 2022. Patients were classified into two groups: those with postoperative survival >1 year (L) and those with postoperative survival ≤1 year (D). Factors assessed included age, sex, body mass index (BMI), cognitive impairment, fracture type, surgical timing, length of hospital stay, implant type, preoperative hemoglobin/albumin/white blood cell levels, and Geriatric Nutritional Risk Index (GNRI). Results: The mean age at surgery was 93.2 ± 2.8 years (mean follow-up = 18.9 months). The 12-month mortality rate was 28.8%. Intertrochanteric fractures were observed in 136/47 patients, and femoral neck fractures were observed in 67/35 patients in the L/D group, respectively (p = 0.13). Days from admission to surgery were not significantly associated with mortality (p = 0.56). The mean hospital stay was 17/22 days in the L/D group, respectively. Univariate analysis identified age, BMI, cognitive impairment, albumin level, and GNRI as statistically significant predictors. Multivariate analysis revealed length of hospital stay (odds ratio [OR] = 1.048 [95% confidence interval (CI): 1.019–1.078]; p = 0.001), cognitive impairment (OR = 3.082 [95% CI: 1.367–6.945]; p = 0.007), and GNRI (OR = 0.929 [95% CI: 0.901–0.958]; p < 0.001) as independent predictors of mortality. Conclusions: This study identified cognitive impairment, a low GNRI, and prolonged hospital stay as independent prognostic factors for 1-year mortality in nonagenarian patients with PFFs. These findings highlight the importance of addressing malnutrition and cognitive decline through tailored interventions, alongside optimizing surgical timing and hospital care. A multidisciplinary approach remains essential for improving survival outcomes in this vulnerable population.

show abstract

Geriatric nutritional risk index as a predictor for postoperative complications in patients with solid cancers: a meta-analysis

Cited by 3 publications

References 49 publications

Significance of the geriatric nutritional risk index and neutrophil-to-lymphocyte ratio as prognostic indicators in older patients with gastric cancer: a retrospective cohort study

Significance of the geriatric nutritional risk index and neutrophil-to-lymphocyte ratio as prognostic indicators in older patients with gastric cancer: a retrospective cohort study

Significance of geriatric nutritional risk index and neutrophil-to-lymphocyte ratio as prognostic indicators in older patients with gastric cancer: A retrospective cohort study

Prognostic Factors for Mortality in Patients Aged 90 Years and Older with Proximal Femoral Fractures Undergoing Surgery: A Retrospective Study

Contact Info

Product

Resources

About