Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes

Park, Ji‐Hae; Mohamed, Mohamed Antar Aziz; Jung, Ye‐Jin; Shrestha, Sabina; Lee, Tae Hoon; Lee, Chang-Ho; Han, Dongil; Kim, Jiyoung; Baek, Nam‐In

doi:10.1007/s12272-014-0525-z

Cited by 10 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the prevention of UVB-induced skin damage caused by collagen breakdown could be, at least in the past, attributed to a reduction in the overexpression of MMP-1. In addition, our finding is consistent with other reports demonstrating that (-)-xanthorrhizol (2), isolated from Curcuma xanthorrhiza, significantly reduced MMP-1 expression in a dose-dependent manner [43], while germacrone (3), also isolated from the same plant species, inhibited protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes and UVB-induced upregulation of the mRNA [44]. However, the molecular mechanism by which the CA and CC extracts Human skin keratinocytes were pre-treated with the tested samples for 24 h before repeated UVB irradiation (100 mJ/cm 2 × 10 times).…”

Section: Evaluation Of the Extracts And Isolated Constituents On Cell...supporting

confidence: 92%

Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells

et al. 2022

View full text Add to dashboard Cite

Ultraviolet-B (UVB) exposure is one of the primary extrinsic factors causing skin photoaging. It stimulates inflammatory responses and arrests the cell cycle. Matrix metalloproteinase-1 (MMP-1) secreted by keratinocytes is one of the important extracellular matrixes to attenuate UVB-induced skin aging via collagen degradation. Curcuma aromatica (CA) and Curcuma comosa (CC), the herbaceous plants in the Zingiberaceae family, are commonly used in Thai traditional women’s medicines. The present work was aimed to investigate the potential of the CA and CC extracts and their isolated compounds to attenuate UVB-induced MMP-1 and cell cycle arrest in HaCaT keratinocytes. Total phenolic contents and antioxidant capacities of the extracts were determined. CC extract contains more phenolic components and provides more potent antioxidant activities than CA extract. HaCaTs were pretreated with the extracts or their isolated constituents 1–4 for 24 h and then repeatedly exposed to UVB at 100 mJ/cm2 10 times. Both extracts and compounds 1–4 effectively reduce UVB-induced MMP-1 levels in HaCaT cells and restore cell cycle arrest. This is the first report on the potential of CA and CC extracts in reducing UVB-induced MMP-1 expression and regulating cell proliferation in HaCaT cells. Thus, CA and CC extracts might be used as alternative natural agents to prevent UVB-induced skin photoaging.

show abstract

Section: Evaluation Of the Extracts And Isolated Constituents On Cell...supporting

confidence: 92%

Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Dehydrocurdione 13 13 7α-hydroxyneocurdione (16) No data 7β-hydroxycurdione (17) No data 13 13-hydroxygermacrone (20) [29] Colorless oil (CHCl 3 ); IR (KBr) cm À1 : 3452, 1679. 1 13…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpene from Myanmar Medicinal Plant (Curcuma comosa)

Tun¹,

Aminah²,

Kristanti³

et al. 2021

Terpenes and Terpenoids - Recent Advances

View full text Add to dashboard Cite

Curcuma comosa (Zingiberaceae) is widely grown in tropical and subtropical areas of Asia, like Thailand, Indonesia, Malaysia, and Myanmar. In Myanmar, the rhizome of Curcuma comosa is called Sa-nwin-ga, and local people had used it as a traditional medicine for stomach ache, diabetes mellitus, and hypertension. This species produces secondary metabolites of phenolic and nonphenolic groups. Phenolic groups like diarylheptanoids and flavonoids. While nonphenolics are terpenoids, especially sesqui- and monoterpenes. In this chapter, the group of sesquiterpene compounds from Curcuma comosa starts from the isolation technique, followed by the elucidation of the molecular structure, and their activity tests have been discussed.

show abstract

“…Currently, 54 germacrane sesquiterpenoids have been isolated from Curcumae Rhizoma (Figure 2, Table 2). These natural products frequently engage in the formation of a five-membered ring at C-8 and C-12, yielding diverse structural moieties, such as furan rings (139)(140)(141)(142)(143)(144)(145), lactone rings (146)(147)(148)(149)(150)(151)(152)(153)(154)(155)(156)(157)(158), and lactam rings (161-168). This type of compound is prone to oxidation, which can produce aldehydes, ketones, esters, or oxygen bridges.…”

Section: Germacrane-type Sesquiterpenoids Of Curcumae Rhizomamentioning

confidence: 99%

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Cui,

Li,

Liu

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Curcumae Rhizoma, a traditional Chinese medicine with a wide range of pharmacological activities, is obtained from the dried rhizomes of Curcuma phaeocaulis VaL., Curcuma kwangsiensis S. G. Lee et C. F. Liang, and Curcuma wenyujin Y. H. Chen et C. Ling. Sesquiterpenoids and curcuminoids are found to be the main constituents of Curcumae Rhizoma. Sesquiterpenoids are composed of three isoprene units and are susceptible to complex transformations, such as cyclization, rearrangement, and oxidation. They are the most structurally diverse class of plant-based natural products with a wide range of biological activities and are widely found in nature. In recent years, scholars have conducted abundant studies on the structures and pharmacological properties of components of Curcumae Rhizoma. This article elucidates the chemical structures, medicinal properties, and biological properties of the sesquiterpenoids (a total of 274 compounds) isolated from Curcumae Rhizoma. We summarized extraction and isolation methods for sesquiterpenoids, established a chemical component library of sesquiterpenoids in Curcumae Rhizoma, and analyzed structural variances among sesquiterpenoids sourced from Curcumae Rhizoma of diverse botanical origins. Furthermore, our investigation reveals a diverse array of sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, and other types, emphasizing the relationship between structural diversity and activity. We hope to provide a valuable reference for further research and exploitation and pave the way for the development of new drugs derived from medicinal plants.

show abstract

Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes

Cited by 10 publications

References 27 publications

Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells

Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells

Sesquiterpene from Myanmar Medicinal Plant (Curcuma comosa)

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Contact Info

Product

Resources

About