Germinoma of the Basal Ganglia

Takeda, Naoya; Fujita, Katsuzo; Katayama, Shigenori; Uchihashi, Yoshito; Okamura, Yusuke; Nigami, Hiroyuki; Hashimoto, Kimio; Kohmura, Eiji

doi:10.1159/000083745

Cited by 24 publications

(2 citation statements)

References 43 publications

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“…[10,23,30] Our imaging findings most likely provide evidence for this clinical problem. Aggravated ipsilateral atrophy of the brain and cerebral peduncle can be observed in the patient who underwent longitudinal MR studies over 2 years.…”

Section: Discussionmentioning

confidence: 82%

Radiologic features of primary intracranial ectopic germinomas

Wei

Shen²,

Tang³

et al. 2016

Medicine

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Rationale:Germinomas are sensitive to radiation therapy and chemotherapy; therefore, correct imaging diagnosis is crucial for them. However, the imaging findings of germinomas originating from off-midline regions displayed different patterns from those originating from midline areas.Patient concerns:The objective of this study is to describe the radiologic features of primary ectopic germinoma. We reviewed the MR and CT findings of 12 patients with histologically proven off-midline ectopic germinomas with off-midline locations.Interventions:All of these patients underwent conventional MR images and 3 of them underwent diffusion images. Additional CT images were available in 3 patients. Analysis was focused on the shape and entity of tumors in images, signs of hemiatrophy, and the involvement of fibers in diffusion images.Outcomes:Well-defined (8/12) and ill-defined margin masses (4/12) were identified according to the shape of the mass. Multicystic masses were seen in 11 of the 12 patients. The solid component of the tumors had a high density (3/3) with calcifications (2/3) on CT images, iso- to hypointensity in T2WI (11/12) and restricted diffusion on apparent diffusion coefficient (ADC) maps (3/3). Hemiatrophy was observed in 5 cases and progressive hemiatrophy was observed in 1 case. Other signs included mild peritumoral edema (10/12), and hydrocephalus (7/12). Additionally, infiltration of the corticospinal tract (CST) was identified on diffusion tensor imaging (DTI) (2/2).Lessons:The results indicate that multicysitic entities and hypointensities in solid components on T2WI and hemiatrophy are the imaging features of ectopic germinomas. DTI has potential for assessing CST involvement.

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Section: Discussionmentioning

confidence: 82%

Radiologic features of primary intracranial ectopic germinomas

Wei

Shen²,

Tang³

et al. 2016

Medicine

View full text Add to dashboard Cite

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“…[31013] Patients present with subtle, but progressive pyramidal signs due to the tumor's proximity to the posterior limb of the internal capsule. [1] Slow infiltration of the basal ganglia and thalamus could lead to extra-pyramidal signs such as choreo-athetosis.…”

Section: Discussionmentioning

confidence: 99%

Progressive hemiparesis in a young man: Hemicerebral atrophy as the initial manifestation of basal ganglia germinoma

et al. 2017

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Basal ganglia germinomas are rare and patients are classically young Oriental males presenting with gradually progressive hemiparesis. Although early treatment with chemo-radiotherapy can be curative and significantly improve the quality of life, medical attention is often delayed. A young Chinese male experienced a 6-month history of right hemiparesis with magnetic resonance imaging findings of hemicerebral atrophy and lentiform nucleus microhemorrhage, highly suggestive and early signs of basal ganglia germinomas. No further imaging was performed until 2 years later when he was admitted for acute neurological deterioration and a repeat scan revealed a large infiltrative tumor pathologically confirmed to be a pure germinoma.

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Bilateral germinoma of the basal ganglia

Rossi

Garrè

Ravegnani

et al. 2007

Pediatric Blood & Cancer

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Germinoma arising in the bilateral basal ganglia is exceedingly rare, with only five cases reported to date. Owing to non-specific clinical findings and the frequent presence of ill-defined abnormalities without a definite tumor mass on neuroimaging, the diagnosis can be difficult. We describe a case in which magnetic resonance spectroscopy (MRS) findings suggested a tumor and supported the decision to perform biopsy of the lesion. © 2006 Wiley-Liss, Inc

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Germinoma of the Basal Ganglia

Cited by 24 publications

References 43 publications

Radiologic features of primary intracranial ectopic germinomas

Radiologic features of primary intracranial ectopic germinomas

Progressive hemiparesis in a young man: Hemicerebral atrophy as the initial manifestation of basal ganglia germinoma

Bilateral germinoma of the basal ganglia

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