“…It is thought to be involved in calcium-independent cell adhesion, signalling, migration, proliferation, and differentiation 1 extracellular domain (ex) with both epidermal growth factor and thyroglobulin repeat-like domains, a transmembrane domain, and a relatively short intracellular domain (icd) 2 . Proteolytic cleavage of epcam leads to the creation of an extracellular domain (epcam-ex) and an intracellular domain (epcam-icd) that consists of a short 26-amino-acid fragment that has been shown to trigger activation of the Wnt/beta-catenin pathway and aggressive tumour behavior 2,3 . In addition, formation of an epcam-icd-beta-catenin complex with other proteins has been shown to lead to transcription and upregulation of several genes, including c-Myc and CCND1, which might promote tumour growth 4 .…”