Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: Associations with tumor progression, age and human papillomavirus infection

Joseph, Thomas; Chacko, Priya; Wesley, Ramani; Jayaprakash, P. G.; James, Francis V.; Pillai, M. Radhakrishna

doi:10.1016/j.ygyno.2005.10.033

Cited by 53 publications

(51 citation statements)

References 32 publications

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“…GSTM1 null genotype has been found more frequently than the GSTT1 null, in agreement with other studies including different populations (Goodman et al 2001, Chan-Yeng et al 2004, Joseph et al 2006, Sobti et al 2006, Singh et al 2008. No correlation was found between GSTM1 null genotype and risk of HPV infection, although GSTM1 seems to be down-regulated in HPV-transfected cells (Chen & Nirunsuksiri, 1999).…”

Section: Discussionsupporting

confidence: 86%

“…No correlation was found between GSTM1 null genotype and risk of HPV infection, although GSTM1 seems to be down-regulated in HPV-transfected cells (Chen & Nirunsuksiri, 1999). Otherwise, women with GSTT1 null genotype and GSTM1/GSTT1 null genotype showed increased risk for HPV infection, in contradition to Joseph et al (2006) that reported higher risk of HPV infection in indian women with GSTM1 null compared with the absence of the GSTT1 gene. GSTM1/GSTT1 null genotype showed a sinergic behavior, probably because both genes seem to be related to protection against mutation in DNA by facilitating the conjugation and elimination of a variety of electrophilic species (Rebbeck 1997).…”

Section: Discussionmentioning

confidence: 62%

“…The inheritance of GSTM1 and GSTP1 null polymorphisms seems to be relevant to HBV infection and disease progression (Ghobadloo et al 2006). Similarly, a higher frequency of GSTT1 and GSTM1 deletions was observed in HPV positive subjects, elevating the risk of precancerous lesion in hungarian and indian populations (Cseh et al 2011, Joseph et al 2006. In this study, we investigated the correlation between GSTM1 and GSTT1 null genotypes and susceptibility to HPV infection and development of cervical lesions in Brazil.…”

Section: Introductionmentioning

confidence: 88%

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Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

Soares¹,

Martins²,

Medeiros³

et al. 2013

VR&R

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Human papillomavirus (HPV) is responsible for developing cancers, among them cervical cancer, which is the second cancer responsible for female mortality. The polymorphism of glutathione S-transferase (GST) is closely linked to an increased risk of cervical lesions and HPV infection. This enzyme is involved in phase II of xenobiotic metabolism, which can eliminate potential toxic carcinogenic compounds from the body. In this study, it was analysed the association between GSTM1 and/or GSTT1 polymorphism and susceptibility to HPV infection or development of cervical lesions. It was also analysed the correlation of these polymorphisms with external factors such as number of sexual partners, parity, smoking and alcohol consumption. Women who had more than one sexual partner presented 2.35 times more chances of being infected by HPV, but it could not be associated to the development of cervical lesions. However, more than three pregnancies leads to high risk (OR=3.2) of developing cervical lesions. Considering the genotypes analyzed in this study, only GSTT1 null showed significant influence on the risk of HPV infection among consumers of alcohol (OR=6.6) and none of them showed influence on the risk of developing cervical lesions (P <0.05). The study of other polymorphisms and expression of GST isoforms and enzymes that act in phase I of xenobiotics metabolism, for example, could lead to further clarification of the effect of oxidative stress on cellular susceptibility to HPV infection, since the results this research point to this interaction.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 88%

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Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

Soares¹,

Martins²,

Medeiros³

et al. 2013

VR&R

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“…With our search criterion, 123 individual records were found, but only 31 full-text articles were preliminarily identified for further detailed evaluation. According to the exclusion criteria, 15 articles were excluded including 5 articles containing overlapping population [7][8][9][10][11], 8 precancerous lesions included in the cases [12][13][14][15][16][17][18][19], 2 without sufficient data [20][21]. At last, data were available from 16 individual case-control studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Table 1 presented characteristics of these 16 case-control studies (a total of 1,627 CC cases and 2,161 controls).…”

Section: Resultsmentioning

confidence: 99%

“…Compared with Economopoulos et al 's meta-analysis, our meta-analysis had some differences. Firstly, our meta-analysis included three new eligible studies published in Chinese [22][23][24] and two new case-control studies [25][26] in English in 2010, and excluded four studies [13,16,18,19] that had precancerous lesions patients in cases. Secondly, Asians (including Chinese, Indians, Koreans, Japanese and Thais), Caucasians and Latinos were stratified by ethnicity in our meta-analysis, while Chinese (including Koreans, Japanese and Thais) and non-Chinese were stratified GSTM1 AND GSTT1 POLYMORPHISMS AND CERVICAL CANCER RISK Fig.…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

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There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

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Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are Associated with Susceptibility and Chemotherapy Response in Non-small-cell Lung Cancer Patients

Yue

Zhang

et al. 2011

Lung

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Our findings support the hypothesis that a polymorphism in GSTM1 is associated with lung cancer susceptibility. Furthermore, polymorphisms in GSTM1 and CYP1A1 were associated with chemotherapy response. In particular, smokers carrying deficient-type GSTM1 were at a higher risk of developing lung cancer. Patients carrying deficient-type GSTM1 responded better to platinum drugs, while those with TT CYP1A1 were better responders to nonplatinum drugs.

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Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: Associations with tumor progression, age and human papillomavirus infection

Cited by 53 publications

References 32 publications

Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are Associated with Susceptibility and Chemotherapy Response in Non-small-cell Lung Cancer Patients

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