Germline miRNA DNA variants and the risk of colorectal cancer by subtype

Lindor, Noralane M.; Larson, Melissa C.; DeRycke, Melissa S.; McDonnell, Shannon K.; Baheti, Saurabh; Fogarty, Zachary C.; Win, Aung Ko; Potter, John D.; Buchanan, Daniel D.; Clendenning, Mark; Newcomb, Polly A.; Casey, Graham; Gallinger, Steven; Marchand, Loı̈c Le; Hopper, John L.; Jenkins, Mark A.; Goode, Ellen L.; Thibodeau, Stephen N.

doi:10.1002/gcc.22420

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…Noticeably, the GG genotype was associated with a high risk of CRC in males [ 23 ] and females [ 24 ] in two different Asian cohorts. According to our knowledge, there are nine other studies that found that rs2910164 was not related to CRC risk ( Table 1 ) [ 15 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

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Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.

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Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

“…Several studies link rs11614913 polymorphism with the risk of CRC [ 21 , 24 , 45 , 46 , 47 , 48 ]. On the other hand, 10 studies do not confirm this association [ 17 , 18 , 25 , 26 , 27 , 29 , 30 , 49 , 50 ].…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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“…In addition, the dysregulation of miRNA is involved in numerous important steps of carcinogenesis, from initiation to metastasis . Recently, Lindor et al have shown that miR‐3191 was associated with CRC. In their study, germline genetic variations in 1123 miRNAs were analyzed from 899 CRC patients and 204 controls, and they identified 30 variants and 29 miRNAs associated with CRC, including miR‐3191.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer

Zhao

Zhu

et al. 2019

J Biochem & Molecular Tox

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Mutations in transforming growth factor beta receptor II (TGFBR2) are detected in up to 30% of overall colorectal cancer (CRC). Dysregulation of some microRNAs participated in the CRC pathogenesis. In this study, we used the gene ontology analyses, the Kyoto Encyclopedia of Genes and Genomes pathway analyses and gene set enrichment analysis to indicate that miR-3191 was involved in the regulation of transforming growth factor beta (TGF-BETA) signal pathway in CRC. These bioinformatics results were supported by data obtained from CRC samples and experiments in vitro. The luciferase reporter assay was used to confirm that miR-3191 modulates TGF-BETA signal pathway by targeting TGFBR2. By transwell migration and invasion assays, we showed that miR-3191 promoted CRC cell migration and invasion by downregulating TGFBR2. And it may serve as a novel therapeutic strategy for treating CRC patients. K E Y W O R D Scolorectal cancer (CRC), migration, miR-3191, transforming growth factor beta (TGF-BETA) signal pathway, transforming growth factor beta receptor II (TGFBR2) J Biochem Mol Toxicol. 2019;33:e22308.wileyonlinelibrary.com/journal/jbt

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“…NOS scores of the included studies were summarized in Table 5 . According to the criterion mentioned in previous study [ 42 , 43 ], we found that only two investigations were poor quality studies [ 36 , 44 ]. When we omitted these poor quality investigations, the findings were not changed.…”

Section: Resultsmentioning

confidence: 96%

“…The quality evaluation was used to improve the preent study. In the meta-analysis, we found that only two investigations were poor quality study [ 36 , 44 ]. In subgroup analysis, when we omitted them, the findings were not altered materially.…”

Section: Discussionmentioning

confidence: 99%

Lack of association betweenmiR-146ars2910164 C/G locus and colorectal cancer: from a case–control study to a meta-analysis

et al. 2021

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Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003 CRC patients and 1303 controls, and performed a case–control study to clarify the correlation of miR-146a rs2910164 locus with CRC risk. Subsequently, a comprehensive meta-analysis was conducted to verify our findings. In the case–control study, we suggested that miR-146a rs2910164 variants did not alter CRC risk (CG vs. CC: adjusted P=0.465; GG vs. CC: adjusted P=0.436, CG/GG vs. CC: adjusted P=0.387 and GG vs. CC/CG: adjusted P=0.589), even in subgroup analysis. Next, we conducted a pooled-analysis to identify the correlation of miR-146a rs2910164 locus with CRC risk. In this pooled-analysis, 7947 CRC cases and 12,168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P=0.537; GG vs. CC: P=0.517, CG/GG vs. CC: P=0.520 and GG vs. CC/CG: P=0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. In the future, more case–control studies are needed to confirm our results.

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Germline miRNA DNA variants and the risk of colorectal cancer by subtype

Cited by 8 publications

References 24 publications

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

MicroRNA‐3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer

Lack of association betweenmiR-146ars2910164 C/G locus and colorectal cancer: from a case–control study to a meta-analysis

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