2021
DOI: 10.1007/s10522-021-09911-4
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Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster

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Cited by 9 publications
(4 citation statements)
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“…Looking at hydrogen sulfide (HSO) homeostasis, Alexey Moskalev, Russian academy of Sciences, Russia, has found that its disruption is associated with aging and therefore a potential gero-therapeutic target. He showed that combined genetic and therapeutic interventions of HSO metabolism led to beneficial effects of HSO production and life-and health span extension in D. melanogaster along with stress resistance [14]. Another novel mechanism to regulate homeostasis at the embryonic level is through adrenal steroidogenesis.…”
Section: Longevity Pathwaysmentioning
confidence: 99%
“…Looking at hydrogen sulfide (HSO) homeostasis, Alexey Moskalev, Russian academy of Sciences, Russia, has found that its disruption is associated with aging and therefore a potential gero-therapeutic target. He showed that combined genetic and therapeutic interventions of HSO metabolism led to beneficial effects of HSO production and life-and health span extension in D. melanogaster along with stress resistance [14]. Another novel mechanism to regulate homeostasis at the embryonic level is through adrenal steroidogenesis.…”
Section: Longevity Pathwaysmentioning
confidence: 99%
“…Анализ выживаемости. Оценку выживаемости и статистическую обработку данных выполняли по методике, описанной ранее [15,16]. Эксперимент проводили в трех независимых биологических повторностях.…”
Section: материалы и методыunclassified
“…4,23 Boosting endogenous H 2 S level is able to prolong lifespan in several model organisms, including yeast, flies, worms, and mice. 5,[24][25][26][27] It is widely reported that H 2 S exerts its biological activities through the S-sulfhydration modification of active cysteine residues, thus blocking irreversible oxidation and altering the functions of target proteins. [28][29][30][31] The global S-sulfhydrated proteins (sulfhydrome) have been shown to be disrupted in aging tissues from mice.…”
Section: Introductionmentioning
confidence: 99%
“…H 2 S mediates the beneficial effect of caloric restriction in promoting longevity 4,23 . Boosting endogenous H 2 S level is able to prolong lifespan in several model organisms, including yeast, flies, worms, and mice 5,24‐27 . It is widely reported that H 2 S exerts its biological activities through the S ‐sulfhydration modification of active cysteine residues, thus blocking irreversible oxidation and altering the functions of target proteins 28‐31 .…”
Section: Introductionmentioning
confidence: 99%