Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster

Izmaylov, D.M.; Obukhova, L. K.

doi:10.1016/s0047-6374(98)00105-5

Cited by 47 publications

(21 citation statements)

References 18 publications

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“…Таким образом, снижение про-должительности жизни в условиях постоянного освеще- -и NO-зависимые стресс-реакции в клетке (Hardeland, 2005). Однако дан-ные о влиянии мелатонина на продолжительность жизни D. melanogaster, полученные ранее другими авторами, являются противоречивыми: в ряде работ не удалось наблюдать однозначного геропротекторного действия мелатонина (Anisimov et al, 1997;Izmaylov et al, 1999), тогда как в других работах он присутствует (Bonilla et al, 2002). В некоторых экспериментах на мышах так-же не было обнаружено мелатонин-зависимого про-дления жизни .…”

Section: таблицаunclassified

Melatonin influence on Drosophila melanogaster life span at different light regimes

Moskalev

Krementsova

Malysheva

2008

Ecological genetics

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It was investigated the combined effects of different light regimes (round-the-clock lighting or darkening) and antioxidant melatonin on Drosophila melanogaster life span of wild type strain Canton-S,mutant strain with defect of red-ox system (Sod) and mu tant strain with disturbance of excision DNA repair (mus210). It was revealed, that maintenance of Drosophila imago at round-the-clock lighting leads to decrease of mean and/or maximum life span with compare to being at darkening. Adding of melatonin to Drosophila meal induces the geroprotector effects, mainly, in dark conditions. The effects mentioned above were most expressed in strain with mutation of Sod. All effects have revealed in both sexes. The data analysis has shown that mechanisms of different light regimes and melatonin influ ence on life span are rather different.

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Section: таблицаunclassified

Melatonin influence on Drosophila melanogaster life span at different light regimes

Moskalev

Krementsova

Malysheva

2008

Ecological genetics

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“…Melatonin (Bonilla et al 2002;Izmaylov and Obukhova 1999;Anisimov et al 1997). However, with the exception of Coenzyme Q 10 , the other antioxidants mentioned have been shown to have differing lifespan effects both in the same organism (Harrington and Harley 1988;Adachi and Ishii 2000;Ishii et al 2004;Driver and Georgeou 2003) and between species (Driver and Georgeou 2003;Bonilla et al 2002;Izmaylov and Obukhova 1999;Anisimov et al 1997;Anisimov 2003).…”

Section: Pharmacological Interventions That Increase Lifespanmentioning

confidence: 99%

Pharmacological intervention in invertebrate aging

Lithgow

Gill

Olsen

et al. 2005

AGE

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Prompted by successful genetic interventions in aging we now consider the utility of pharmacological interventions. A few clear cases of lifespan extension resulting from exposure to compounds suggest that aging can be slowed and that the pharmacology of lifespan extension is a feasible area for research. Compounds that slow aging may prompt the rational design of therapeutics against age-related diseases. Here we evaluate invertebrate models for drug discovery in aging and outline how the field may develop from these simple first steps.

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“…A pinealectomy resulted in the reduction in life span in rats (87,130) whereas grafting a pineal gland from young donors into the thymus of old syngenetic mice or in situ into pinealectomized old mice prolongs the life span of the recipients (77,117). The capacity of melatonin to extend life span is a hot topic (12,18,67,68,114,128,129,133,165).…”

Section: Introductionmentioning

confidence: 99%

Effects of Exogenous Melatonin—A Review

Anisimov

2003

Toxicol Pathol

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The results of studies on the effect of pineal indole hormone melatonin on the life span of mice, rats, fruit flies, and worms are critically reviewed. In mice, long-term administration of melatonin was followed by an increase in their life span in 12 experiments and had no effect in 8 of 20 different experiments. In D. melanogaster, the supplementation of melatonin to the nutrient medium during developmental stages gave contradictory results, but when melatonin was added to food throughout the life span, an increase in the longevity of fruit flies has been observed. Melatonin decreased the survival of C. elegans but increased the clonal life span of planaria Paramecium tertaurelia. Available data suggest antioxidant and atherogenic effects of melatonin. Melatonin alone turned out to be neither toxic nor mutagenic in the Ames test and revealed clastogenic activity in high concentration in the COMET assay. Melatonin inhibits mutagenesis induced by irradiation and by indirect chemical mutagens and inhibits the development of spontaneous and chemical-induced tumors in mice and rats. Further studies and clinical trials are needed to verify that melatonin is both safe and has geroprotector efficacy for humans.

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Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster

Cited by 47 publications

References 18 publications

Melatonin influence on Drosophila melanogaster life span at different light regimes

Melatonin influence on Drosophila melanogaster life span at different light regimes

Pharmacological intervention in invertebrate aging

Effects of Exogenous Melatonin—A Review

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