Gestation-wise Reference Ranges of Neutrophil Counts in Indian Newborns

Das, Abhishek; Ray, Santanu; Chattopadhyay, Arnab; Hazra, Avijit; Mondal, Rakesh

doi:10.5001/omj.2019.25

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…10 A publicaAon by Manroe et al, established a method for determining whether a neonate's neutrophil count should be considered neutrophilic, normal, or neutropenic. 11 The physiological immune response of circulaAng leukocytes to stressful events is characterized by a raised neutrophil count and decreased lymphocyte count. A microbial infecAon causes an increase of the total leukocyte and neutrophil counts and results in an inflammatory reacAon.…”

Section: Introductionmentioning

confidence: 99%

The Use of Absolute Neutrophil Count and Neutrophil-Lymphocyte Ratio as Predictors of Early Onset Neonatal Sepsis.

Manding,

Yala

2023

PIDSPJ

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Background: Neonatal sepsis contributes to significant morbidity and mortality. Blood culture, the gold standard in its diagnosis, has low sensitivity and is affected by multiple factors. Hence the need for markers derived from routine tests to improve diagnosis deserves further studies. Objectives: This study aims to determine the association and optimal cut-off value and diagnostic performance of absolute neutrophil count (ANC) and neutrophil lymphocyte ratio (NLR) with early-onset neonatal sepsis in term neonates. Methodology: This was a retrospective, analytical, single-center study of admitted patients from January 2016 to December 2021. Clinical factors were analyzed and NLR and ANC were derived from CBC and interpreted using the Manroe chart. Results: Included were 200 neonates with a median birth AOG of 38 weeks. Microorganisms were isolated from nine of 154 neonates with blood culture, corresponding prevalence of 5.84% (95% CI 2.71–10.80). Initial CBC showed elevated mean WBC and 76.5% of neonates were considered to have elevated ANC. Optimal cut-off point of NLR for detecting culture-proven sepsis was 2.86, with a sensitivity of 88.89% (95% CI, 51.75–99.72%) and specificity of 36.55% (95% CI, 28.72–44.95%). The ANC gave the best balance of sensitivity and specificity with an accuracy of 75.50%. Conclusions: The NLR demonstrated good discriminative ability for predicting clinical neonatal sepsis based on ANC. However, individually or simultaneously, these markers demonstrated poor discriminative ability for culture-proven neonatal sepsis in term neonates. ANC and NLR can be used to aid in the diagnosis of clinical neonatal sepsis.

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Section: Introductionmentioning

confidence: 99%

The Use of Absolute Neutrophil Count and Neutrophil-Lymphocyte Ratio as Predictors of Early Onset Neonatal Sepsis.

Manding,

Yala

2023

PIDSPJ

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Can Platelet Mass Index Predict Respiratory Support Duration in Late Preterm Infants with Transient Tachypnea of the Newborn?

Şahin¹,

GÜNEŞ²,

Öncel

2022

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Aim: Transient tachypnea of the newborn (TTN) is the most common respiratory problem encountered by physicians working in the neonatal intensive care unit, and its incidence is higher in late preterm infants compared to term infants. Platelets prevent pulmonary fluid collection and pulmonary edema by an unknown mechanism. Platelet function can be more accurately assessed by platelet mass index (PMI) rather than mean platelet volüme (MPV) or platelet count alone. In our study, it was planned to investigate the duration of need for respiratory support and the relationship between thrombocyte markers, especially PMI, and other respiratory outcomes in late preterm infants with the diagnosis of TTN. Materials and Methods: In this retrospective study, data of all late preterm newborns whose tachypnea lasted for at least 12 hours and who were hospitalized in the neonatal intensive care unit of Buca Seyfi Demirsoy Training and Research Hospital with the diagnosis of TTN between August 1, 2020-July 31, 2021 were analyzed from medical records. The thrombocyte markers, leukocyte and neutrophil values of the infants and respiratory support durations were compared. In addition, these parameters were evaluated in terms of possible differences according to gestational weeks. Results: 52 infants were included in the study. The median gestational week was 35 weeks (34-366/7), and the mean birth weight was 2647474. There was no correlation between total respiratory support duration or >48 hours of respiratory support in infants and platelet count, MPV, PMI, leukocyte and absolute neutrophil count (ANS). However, it was observed that the PMI values were lower in babies who received respiratory support for more than 72 hours, and this was statistically significant. In addition, it was observed that MPV value was significantly higher in babies born at 35th gestational week and ANS value was significantly higher in babies born at 36th gestational week. Conclusion: In our study, it was seen that PMI, one of the platelet markers, was associated with the need for respiratory support for more than 72 hours in late preterm infants with TTN, as the mean PMI values of these infants being lower. However, a similar relationship was not found between other platelet markers and the duration of respiratory support.

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