Gestational Age and Neonatal Electrocardiograms

Hartmann, Joachim; Pærregaard, Maria Munk; Norsk, Jakob; Pietersen, Adrian; Iversen, Kasper; Bundgaard, Henning; Christensen, Alex Hørby

doi:10.1542/peds.2021-050942

Cited by 8 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a large prospective general population study, the analysis of newborn ECG parameters showed a trend of decreasing HR as GA increased. 13 This inverse correlation between GA and HR is supported by previous studies. 14,15 In the present study, GA was negatively associated with the mean HR in univariate analysis, but not in the multivariate regression analysis.…”

Section: Discussionsupporting

confidence: 80%

Heart rate in newborns is associated with age, sex and maternal levothyroxine therapy

Uusitalo,

Tikkakoski,

Lehtinen

et al. 2024

Acta Paediatrica

View full text Add to dashboard Cite

AimTo evaluate the definition and causes of neonatal bradycardias.MethodsThis retrospective study included 135 term‐born newborns referred for 24‐hour Holter monitoring due to bradycardia. Bradycardia was defined as either a heart rate below 80 beats per minute (standard definition) or a heart rate below our recently published age‐specific reference values for neonatal heart rate.ResultsThe mean (SD) age was 6.1 (1.3) days. With standard definition, 107 newborns (79%) had bradycardia, whereas only 20 (15%) had a minimum heart rate lower than the age‐specific reference. Younger newborns had lower heart rates. Each day increased the minimum, mean and maximum heart rate by 1.8 (95% CI: 1.0, 2.6), 4.2 (95% CI: 3.0, 5.3) and 2.1 beats per minute (95% CI: 0.3, 3.8), respectively. Male sex and maternal levothyroxine medication were negatively associated with the mean and maximum heart rate. None of the newborns had a cardiac cause for low heart rate.ConclusionAmong term newborns with bradycardias, younger age, male sex and maternal levothyroxine medication were associated with a lower heart rate on Holter monitoring. Given the age‐related increase in heart rate, the 80 beats per minute limit as a universal threshold for abnormal heart rate in newborns appears inappropriate.

show abstract

Section: Discussionsupporting

confidence: 80%

Heart rate in newborns is associated with age, sex and maternal levothyroxine therapy

Uusitalo,

Tikkakoski,

Lehtinen

et al. 2024

Acta Paediatrica

View full text Add to dashboard Cite

show abstract

“…Indeed, small differences in GA, height, and calculated BSA existed between twins and singletons. We have previously reported that GA was significantly associated with most investigated ECG parameters with persistent effect after multifactorial adjustment 21 . A heritable component has been reported for several ECG parameters including heart rate, PR interval, QRS duration, QT interval, and T‐wave characteristics 12,13 .…”

Section: Discussionmentioning

confidence: 94%

“…We have previously reported that GA was significantly associated with most investigated ECG parameters with persistent effect after multifactorial adjustment. 21 A heritable component has been reported for several ECG parameters including heart rate, PR interval, QRS duration, QT interval, and T-wave characteristics. 12,13 The genetic contribution to ECG parameters has been found higher in MZ twins than dizygotic twins and may need to be taken into account if performing ECG screening of twins.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac findings in newborn twins

et al. 2022

Self Cite

View full text Add to dashboard Cite

AimsTo evaluate cardiac findings in newborn twins from the general population and investigate if newborn twins may require systematic evaluation of cardiac parameters.MethodsProspective cohort study of newborns with cardiac evaluation performed during the first month of life. Cardiac findings were compared 1:3 with matched singletons.ResultsWe included 412 newborn twins (16% monochorionic; 50% boys) and 1236 singletons. Comparing cardiac findings showed twins had an increased prevalence of non‐severe structural heart disease (most common: ventricular septal defects in both groups), thinner left ventricular posterior wall in diastole (LVPWd; 1.82 vs. 1.87 mm, p = 0.02), smaller diameter of the left atrium (10.6 vs. 11.1 mm, p = 0.04), higher heart rate (148 vs. 144 bpm, p = 0.04), more left‐shifted QRS axis (106 vs. 111°, p < 0.001), and lower maximum R‐wave amplitude in V1 (927 vs. 1015 μV, p = 0.02) compared to singletons. After multifactorial adjustment for potential confounders, the effect of twinning on cardiac parameters persisted only for LVPWd (p < 0.05).ConclusionDespite contemporary surveillance, we found an increased prevalence of non‐severe structural heart disease in a population‐based cohort of newborn twins. However, the effect of twinning on cardiac parameters was modest and generally did not persist after correction for likely confounding factors.

show abstract

“…ECGs were stored in the MUSE ECG management software (Version 8, GE Healthcare, Milwaukee, USA). The ECG data were validated by medical doctors to ensure adequate data quality, as previously described [ 21 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

Electrocardiographic Characteristics in 438 Neonates with Atrial Septal Defects

Dehn,

Pærregaard,

Sellmer

et al. 2023

Pediatr Cardiol

Self Cite

View full text Add to dashboard Cite

Arrhythmias and electrocardiographic (ECG) abnormalities are common among patients with atrial septal defects (ASDs). We studied a large cohort of neonates with ASDs to investigate whether ECG abnormalities are present at this early stage or develop later, secondary to hemodynamic changes. We analyzed the echocardiograms and ECGs from the Copenhagen Baby Heart Study, a population-based cohort study. We compared ECG characteristics of 438 neonates with secundum ASDs to 1314 matched controls. In subgroup analyses, we investigated whether electrocardiographic characteristics were associated with age at examination. Neonates with ASDs (median age, 11 days; males, 51%) had longer P-wave durations (58 vs. 56 ms, p < 0.001), PR intervals (100 vs. 96 ms, p < 0.001), and a more rightward-shifted QRS axis (116 vs. 114 degrees, p = 0.032) compared to controls (median age, 10 days; males, 51%). There were no differences between cases and controls in the P-wave area, amplitude, or axis. Subgroup analyses showed that the differences in P-wave duration and PR interval were present in neonates examined in the first week after birth. The difference in the QRS axis was not found in neonates examined this early but was found in neonates examined at age two to four weeks. In conclusion, ASDs are associated with ECG changes from the neonatal phase. The P-wave duration and PR interval are longer in neonates with ASDs when compared to controls as early as the first week after birth, indicating that these changes are not purely secondary, but that neonates with an ASD have altered cardiac electrical activity.ClinicalTrials.gov Identifier NCT02753348 (April 27, 2016)

show abstract

Gestational Age and Neonatal Electrocardiograms

Cited by 8 publications

References 27 publications

Heart rate in newborns is associated with age, sex and maternal levothyroxine therapy

Heart rate in newborns is associated with age, sex and maternal levothyroxine therapy

Cardiac findings in newborn twins

Electrocardiographic Characteristics in 438 Neonates with Atrial Septal Defects

Contact Info

Product

Resources

About