Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: Developmental neurotoxicity

Butenhoff, John L.; Ehresman, David J.; Chang, Shu‐Ching; Parker, George A.; Stump, Donald G.

doi:10.1016/j.reprotox.2008.12.010

Cited by 117 publications

(67 citation statements)

References 44 publications

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“…These results are in agreement with the poor performance in the last run on the accelerating rotarod, as well as with lower muscle strength found in exposed males evaluated by the hanging wire test. Decreased hind limb grip strength in young male rats exposed prenatally to 1 mg/kg of PFOS was earlier reported by Butenhoff et al (2009), but this effect was transient and no other muscle strength abnormalities were observed. In contrast, we found that PFOS-exposed females had somewhat lower locomotor activity in the individual and group tests, but these alterations did not reach significance, and muscle strength was not affected.…”

Section: Discussionsupporting

confidence: 70%

“…However, in the other trials they performed as efficiently as their respective controls * P \ 0.05 vs. male control; # P \ 0.05 vs. female control (repeated measures ANOVA followed by LSD test) exposure appears to be sex-related and differs between PFOS and PFOA. In Butenhoff et al (2009), the no-observed-adverseeffect-level (NOAEL) for developmental neurotoxicity in rats was considered to be 0.3 mg/kg/day of PFOS received prenatally. In our experiment, exposure of pregnant mice to 0.3 mg/kg/day of PFOS resulted in PFOS tissue levels (brain and liver from pups at PND1) similar to those observed in rat fetuses at GD20 ) and induced neurobehavioral alterations in the offspring.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner

et al. 2010

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Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are organic surfactants widely used in various industrial and consumer applications. Due to their chemical properties, these perfluorinated compounds (PFCs) have also become persistent contaminants. The risk of possible intrauterine and lactational exposure to these chemicals poses a significant health concern for potential developmental effects. In the present study we have found that dietary exposure of mice to 0.3 mg/kg of PFOS or PFOA throughout pregnancy results in different distribution pattern in the offspring brain and liver. In particular, exposure to PFOS led to four times higher accumulation of the chemical in the brains of newborn mice than PFOA. We have used a battery of behavioral tests to evaluate motor function, circadian activity, and emotion-related behavior in the exposed offspring. Exposure to PFOS resulted in decreased locomotion in a novel environment and reduced muscle strength only in male offspring. Prenatal exposure to PFOA was associated with changes in exploratory behavior in male and female offspring, as well as with increased global activity in males in their home cage. The neurobehavioral outcome of prenatal exposure to PFCs in mice is characterized by mild alterations in motor function and it appears to be sex-related.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner

et al. 2010

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“…The inhibition of 11␤-HSD2 by PFOS during pregnancy could result in glucocorticoid-mediated effects with dangerous consequences. For example, gestational exposure of experimental animals, including rats, to PFOS or PFOA results in reduced birth weight and weight gain at maturity [28]. Recently, human cohort studies also showed correlations between serum levels of PFOS plus PFOA and low birth weight [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances

Zhao

Lian²,

Chu

et al. 2011

The Journal of Steroid Biochemistry and Molecular Biology

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“…One study by using the Morris water maze found effects on learning and memory in mice at approximately 2 mg/kg/day (Long et al, 2013). Developmental neurotoxicity studies in rats found increased motor activity and decreased habituation and increased escape latency in the water maze test following in utero and lactational exposure to PFOS (Butenhoff et al, 2009). Ten-day old male mice exposed to PFOS showed affected habituation up to 4 months of age (Johansson et al, 2008).…”

Section: Animal Studiesmentioning

confidence: 99%

Differential toxicity between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)

Tsuda

2016

J. Toxicol. Sci.

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-Perfluoroalkyl substances (PFASs) are persistent environmental contaminants. Perfluorooctane sulfonate (PFOS) and Perfluorooctanoic acid (PFOA) are representatives of PFASs. Recently, the U.S. Environmental Protection Agency (US EPA) set the health advisory level as 70 parts per trillion for lifetime exposure to PFOS and PFOA from drinking water, based on the EPA's 2016 Health Effects Support Documents. Then, a monograph on PFOA was made available online by the International Agency for Research on Cancer, where the agency classified PFOA as "possibly carcinogenic to humans" (Group 2B). The distinction between PFOS and PFOA, however, may not be easily understood from the above documents. This paper discussed differential toxicity between PFOS and PFOA focusing on neurotoxicity, developmental toxicity and carcinogenicity, mainly based on these documents. The conclusions are as follows: Further mechanistic studies may be necessary for ultrasonic-induced PFOS-specific neurotoxicity. To support the hypothesis for PFOS-specific neonatal death that PFOS interacts directly with components of natural lung surfactant, in vivo studies to relate the physicochemical effects to lung collapse may be required. PFOA-induced DNA damage secondary to oxidative stress may develop to mutagenicity under the condition where PFOA-induced apoptosis is not sufficient to remove the damaged cells. A study to find whether PFOA induces apoptosis in normal human cells may contribute to assessment of human carcinogenicity. Studies for new targets such as hepatocyte nuclear factor 4α (HNF4α) may help clarify the underlying mechanism for PFOA-induced carcinogenicity.

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Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: Developmental neurotoxicity

Cited by 117 publications

References 44 publications

Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner

Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner

The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances

Differential toxicity between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)

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