Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin primes cortical microglia to tissue injury

Lowery, Rebecca L.; Latchney, Sarah E.; Peer, R.P.; Lamantia, Cassandra E.; Lordy, Katheryn A.; Opanashuk, Lisa A.; McCall, Matthew N.; Majewska, Ania K.

doi:10.1016/j.bbi.2022.01.013

Cited by 6 publications

(4 citation statements)

References 85 publications

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“…While microglial dynamics were unaffected by developmental ethanol exposure, we wanted to examine whether other microglial functions may be affected. Microglia respond to infection, insult, and injury, and changes in their ability to respond to pathological stimuli have been observed after developmental perturbations, including potentially after ethanol exposure [ 30 , 31 , 44 , 45 ]. To determine whether developmental ethanol exposure affects the ability of microglia to respond to focal injury in adulthood, we examined the dynamic chemotaxis of microglial processes to a laser ablation in vivo.…”

Section: Resultsmentioning

confidence: 99%

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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Cealie,

Douglas,

Swan

et al. 2024

Cells

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Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death. Alterations in the sole output of the cerebellar cortex, Purkinje cells, and central nervous system immune cells, microglia, have been reported in animal models of FASD. To determine how developmental ethanol exposure affects adult cerebellar microglia and Purkinje cells, we used a human third-trimester binge exposure model in which mice received ethanol or saline from postnatal (P) days 4–9. In adolescence, cerebellar cranial windows were implanted and mice were aged to young adulthood for examination of microglia and Purkinje cells in vivo with two-photon imaging or in fixed tissue. Ethanol had no effect on microglia density, morphology, dynamics, or injury response. However, Purkinje cell linear frequency was reduced by ethanol. Microglia–Purkinje cell interactions in the Purkinje Cell Layer were altered in females compared to males. Overall, developmental ethanol exposure had few effects on cerebellar microglia in young adulthood and Purkinje cells appeared to be more susceptible to its effects.

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Section: Resultsmentioning

confidence: 99%

“…In some instances, developmental insults can result in microglial priming, without overt changes to microglia when assessed at baseline [ 30 , 31 , 44 , 45 ]. Priming effects become evident on the presentation of a secondary insult or “second hit” later in life which elicits a larger microglial response.…”

Section: Discussionmentioning

confidence: 99%

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Cealie,

Douglas,

Swan

et al. 2024

Cells

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“…While environmental toxicants can modulate microglia activity, inducing changes in dynamics ( Lowery et al, 2022 ) and morphology ( Yi et al, 2012 ) indicative of classical microglial reactivity, very few studies have examined exercise regulation of microglia activity in response to toxicant exposure. The models that have include fluoride ( Wang J. et al, 2021 ) and ozone ( Valdez et al, 2020 ) exposure, as well as a model of Gulf war illness, which encompassed daily exposure to mosquito-repellant N, N-diethyl-m-toluamide (DEET), insecticide permethrin (PER), and nerve gas prophylactic drug pyridostigmine bromide (PB), accompanied by 15 min of restraint stress for 4 weeks ( Kodali et al, 2021 ; Figure 8B ).…”

Section: Exercise Interacts With Lifestyle Factors To Modulate Microg...mentioning

confidence: 99%

Physical exercise regulates microglia in health and disease

Strohm,

Majewska

2024

Front. Neurosci.

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There is a well-established link between physical activity and brain health. As such, the effectiveness of physical exercise as a therapeutic strategy has been explored in a variety of neurological contexts. To determine the extent to which physical exercise could be most beneficial under different circumstances, studies are needed to uncover the underlying mechanisms behind the benefits of physical activity. Interest has grown in understanding how physical activity can regulate microglia, the resident immune cells of the central nervous system. Microglia are key mediators of neuroinflammatory processes and play a role in maintaining brain homeostasis in healthy and pathological settings. Here, we explore the evidence suggesting that physical activity has the potential to regulate microglia activity in various animal models. We emphasize key areas where future research could contribute to uncovering the therapeutic benefits of engaging in physical exercise.

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“…While environmental toxicants can modulate microglia activity, inducing changes in dynamics (Lowery et al, 2022) and morphology (Yi et al, 2012) indicative of classical microglial reactivity, very few studies have examined exercise regulation of microglia activity in response to toxicant exposure. The models that have include fluoride and ozone (Valdez et al, 2020) exposure, as well as a model of Gulf war illness, which encompassed daily exposure to mosquito-repellant N, N-diethylm-toluamide (DEET), insecticide permethrin (PER), and nerve gas prophylactic drug pyridostigmine bromide (PB), accompanied by 15 min of restraint stress for 4 weeks (Kodali et al, 2021; Figure 8B).…”

Section: Exercise Interacts With Lifestyle Factors To Modulate Microg...mentioning

confidence: 99%

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Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin primes cortical microglia to tissue injury

Cited by 6 publications

References 85 publications

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Physical exercise regulates microglia in health and disease

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