Gestational and neonatal‐onset hypothyroidism alters androgen receptor status in rat prostate glands at adulthood

Aruldhas, M. M.; Neelamohan, R; Jaganathan, Anbalagan; Sashi, A. M. J.; Stanley, Jone A.; Nagappan, Arumugam Suriyam; Jyothilakshmi, Vasavan; Annapoorna, K; Seshadri, Venkatesh Nagamangalam

doi:10.1002/pros.21101

Cited by 23 publications

(15 citation statements)

References 55 publications

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“…[42] Geatational MMI exposure to rats decreased AR mRNA levels in dorsolateral prostate lobe but surprisingly increased AR mRNA levels in ventral lobe in pups. [43] Maran et al . (1998)[44] reported a stimulatory effect of thyroid hormones on rat prostatic glycosidase activities such as β-glucosidase, β-galactosidase, β-N-acetylglucosaminidase and β-N-acetylgalactosaminidase while opposite effects were reported in thyroidectomized rats.…”

Section: Thyroid Hormones and Reproductive Tract And Sex-accessory Glmentioning

confidence: 99%

Thyroid and male reproduction

Kumar

Shekhar

Dhole

2014

Indian J Endocr Metab

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Male reproduction is governed by the classical hypothalamo-hypophyseal testicular axis: Hypothalamic gonadotropin releasing hormone (GnRH), pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH) and the gonadal steroid, principally, testosterone. Thyroid hormones have been shown to exert a modulatory influence on this axis and consequently the sexual and spermatogenic function of man. This review will examine the modulatory influence of thyroid hormones on male reproduction.

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Section: Thyroid Hormones and Reproductive Tract And Sex-accessory Glmentioning

confidence: 99%

Thyroid and male reproduction

Kumar

Shekhar

Dhole

2014

Indian J Endocr Metab

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“…It is an accepted concept that the impact of any hormone on its direct or indirect targets depends upon its bioavailability and its receptor status in the target tissues [ 26 , 27 ] . Recently, we reported region specifi c diff erential eff ect of gestational and neonatal-onset transient hypothyroidism on AR expression and nuclear ligand binding activity (LBA) in the prostate glands [ 13 ] and epididymis of adult rats [ 28 ] . However, information on AR expression pattern and its association to the intermediary metabolism in muscle phenotypes under such conditions of transient hypothyroidism remains obscure.…”

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confidence: 99%

Transient Gestational and Neonatal Hypothyroidism-induced Specific Changes in Androgen Receptor Expression in Skeletal and Cardiac Muscles of Adult Rat

et al. 2012

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The present study aims to identify the association between androgen status and metabolic activity in skeletal and cardiac muscles of adult rats with transient gestational/neonatal-onset hypothyroidism. Pregnant and lactating rats were made hypothyroid by exposing to 0.05% methimazole in drinking water; gestational exposure was from embryonic day 9-14 (group II) or 21 (group III), lactational exposure was from postnatal day 1-14 (group IV) or 29 (group V). Serum was collected for hormone assay. Androgen receptor status, Glu-4 expression, and enzyme activities were assessed in the skeletal and cardiac muscles. Serum testosterone and estradiol levels decreased in adult rats of groups II and III, whereas testosterone remained normal but estradiol increased in group IV and V, when compared to coeval control. Androgen receptor ligand binding activity increased in both muscle phenotypes with a consistent increase in the expression level of its mRNA and protein expressions except in the forelimb of adult rats with transient hypothyroidism (group II-V). Glut-4 expression remained normal in skeletal and cardiac muscle of experimental rats. Specific activity of hexokinase and lactate dehydrogenase increased in both muscle phenotypes whereas, creatine kinase activity increased in skeletal muscles alone. It is concluded that transient gestational/lactational exposure to methimazole results in hypothyroidism during prepuberal life whereas it increases AR status and glycolytic activity in skeletal and cardiac muscles even at adulthood. Thus, the present study suggests that euthyroid status during prenatal and early postnatal life is essential to have optimal AR status and metabolic activity at adulthood.

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“…AR protein consistently decreased in both DLP and VP of all experimental rats. AR nuclear ligandbinding activity diminished in groups II and IV, whereas it increased in groups III and V. The authors concluded that an optimum thyroid activity during pre-and neonatal period determines AR status in the prostate glands at adulthood [50]. Compromise in the androgen receptor expression as a result of hypothyroidism could affect the physiology of prostate and hence male fertility.…”

Section: Neonatal Thyroid Activity Male Repro-duction and Fertilitymentioning

confidence: 98%

“…Further research has now been undertaken to explore the exact mechanism of pre-pubertal thyroid hormone deficiency induced alteration of reproductive function in adults. Aruldhas et al, (2010) undertook a study on understanding the exact mechanism of hypothyroidism-induced changes in the prostate gland, an androgendependent organ, which contributes a significant portion of the seminal plasma [50]. Hypothyroidism was induced in pregnant and lactating rats by feeding 0.05% methimazole (MMI) through drinking water during fetal and neonatal milestones of testicular and prostatic development.…”

Section: Neonatal Thyroid Activity Male Repro-duction and Fertilitymentioning

confidence: 99%

Thyroid Hormones in Male Reproduction and Fertility

Rajender¹,

Hamada²,

Agarwal

2011

TORSJ

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Thyroid hormones, previously thought not to affect spermatogenesis and male fertility, are now being recognized as having important role in spermatogenesis. The identification of thyroid hormone receptors on Sertoli cells, the nurturing cells for sperm in the testis, has embarked further research to investigate the role of thyroid hormones in male reproduction. Since spermatogenesis occurs in close contact with the Sertoli cells, the thyroid hormones must exert significant regulatory role in sperm production. Therefore, disturbances in the thyroid function could affect spermatogenesis and male fertility. Studies on human subjects and animals models are now revealing further insights into the effect of thyroid hormones on male fertility and infertility. The present review provides an update on the role of thyroid hormones in spermatogenesis and male fertility.

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Gestational and neonatal‐onset hypothyroidism alters androgen receptor status in rat prostate glands at adulthood

Abstract: The results obtained support the proposed hypothesis and indicate that an optimum thyroid activity during pre- and neonatal period determines AR status in the prostate glands at adulthood.

Cited by 23 publications

References 55 publications

Thyroid and male reproduction

Thyroid and male reproduction

Transient Gestational and Neonatal Hypothyroidism-induced Specific Changes in Androgen Receptor Expression in Skeletal and Cardiac Muscles of Adult Rat

Thyroid Hormones in Male Reproduction and Fertility

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