Gestational changes of thyroid function and urinary iodine in thyroid antibody-negative Japanese women

Fuse, Y; Shishiba, Yoshimasa; Irie, Minoru

doi:10.1507/endocrj.ej13-0184

Cited by 20 publications

(20 citation statements)

References 52 publications

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“…It was also reported that the median urinary iodine concentration of pregnant women in Japan was 224 μg/L, and it was more than adequate range for iodine intake according to epidemiological criteria for assessing iodine nutrition Fuse et al 2013). According to a hospital-based study in Japan, SCH might be induced by iodine excess during early pregnancy (Orito et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Women with Subclinical Hypothyroidism Are at Low Risk of Poor Pregnancy Outcome in Japan

Furukawa

Miyakawa

Shibata

et al. 2017

Tohoku J. Exp. Med.

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Maternal subclinical hypothyroidism may be associated with adverse pregnancy outcomes, although not consistently across regions. Here, we sought to determine the effect of elevated thyroid-stimulating hormone (TSH) on pregnancy outcomes in Japanese women without known medical complications. TSH was determined by dried blood spots at 8-20 weeks of gestation, and 3.0-10.0 μ U/mL of TSH was considered as elevated TSH (eTSH). A retrospective study involving 167 cases of eTSH was conducted. Five hundred and seventy eight of controls with normal TSH and without thyroid antibodies were selected. We compared a composite adverse maternal outcome comprised of spontaneous abortion, premature delivery, gestational diabetes mellitus (GDM), placental abruption, and pregnancy-induced hypertension, as well as composite adverse neonatal outcome including stillbirths, heavy for date, light for date, and a low Apgar score (< 7) at 5 minutes between two groups. The incidence of GDM was significantly higher in eTSH (p < 0.01); however, composite adverse maternal and neonatal outcome did not differ between groups (p = 0.19 and p = 0.50, respectively). Although 27 out of 167 cases in eTSH have antibodies, composite adverse outcome did not differ between eTSH with antibodies and controls (p = 0.64 and p = 0.50, respectively). Additionally, composite adverse maternal and neonatal outcome did not differ between the group larger than the median of TSH in eTSH (n = 81) and controls (p = 0.43 and p = 0.98, respectively). Thus, elevated TSH is not associated with overall adverse pregnancy outcomes in women without known medical complications.

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Section: Discussionmentioning

confidence: 99%

Women with Subclinical Hypothyroidism Are at Low Risk of Poor Pregnancy Outcome in Japan

Furukawa

Miyakawa

Shibata

et al. 2017

Tohoku J. Exp. Med.

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“…Similarly, in the study of Rasmussen et al [ 8 ], in the assessment based on iodine-specific food frequency questionnaire, it was stated, that dairy products, other beverages and fish intake contribute 86% of total iodine intake in Danish population, while 53 food items high in iodine were included into questionnaire. However, all food frequency questionnaires must be designed for specific populations that may be observed during analysis of iodine-specific food frequency questionnaire for Japanese population, in which 14 types of algae products were included, as well as 14 types of fish and shellfish [ 73 ]. Taking it into account, it must be indicated, that it is important to obtain the specific questionnaires designed for such populations, for which questionnaires were not created so far.…”

Section: Discussionmentioning

confidence: 99%

Validity and Reproducibility of the Iodine Dietary Intake Questionnaire Assessment Conducted for Young Polish Women

Głąbska

Malowaniec

Guzek

2017

IJERPH

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The aim of this study was to analyse a designed brief iodine dietary intake questionnaire based on a food frequency assessment (IOdine Dietary INtake Evaluation-Food Frequency Questionnaire—IODINE-FFQ), including the assessment of validity and reproducibility in a group of 90 Polish women aged 20–35 years. Participants collected 3-day dietary records and filled in the IODINE-FFQ twice (FFQ1—directly after the dietary record and FFQ2—6 weeks later). The analysis included an assessment of validity (comparison with the results of the 3-day dietary record) and of reproducibility (comparison of the results obtained twice—FFQ1 and FFQ2). In the analysis of validity, a Bland-Altman index of 5.5% and 4.4% was recorded, respectively for FFQ1 and FFQ2. In the analysis of reproducibility it was 6.7%, but the share of individuals correctly classified into tertiles was over 70% (weighted κ of 0.675). It was stated, that assessment of IODINE-FFQ revealed a satisfactory level of validity and reproducibility in the analysis of Bland-Alman plot. The IODINE-FFQ may be indicated as a tool for the assessment of iodine intake in the young women in Poland, however further studies should be considered in order to obtain the practical tool for public health specialists. Due to the lack of validated iodine-specific food frequency questionnaires for countries of Eastern Europe, the IODINE-FFQ may be adjusted for courtiers other than Poland including iodine-fortified products.

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“…Therefore, not only oil-soluble iodinated contrast medium but also iodine-rich foods may be a cause of excessive iodine exposure. Fuse et al [21 ]reported that the median dietary iodine intake was 824.4 μg/day among pregnant Japanese women and 555.3 μg/day among healthy Japanese adults [14]. The World Health Organization (WHO) recommends a daily iodine intake of 250 μg for pregnant women [22].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Neonates Born to Mothers Who Have Undergone Hysterosalpingography Involving an Oil-Soluble Iodinated Contrast Medium

Satoh

Aso²,

Katagiri³

2015

Horm Res Paediatr

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Background/Aims: Patients developing neonatal thyroid dysfunction following maternal hysterosalpingography (HSG) involving the use of oil-soluble iodinated contrast medium (ethiodized oil) have been reported. The present study aimed to investigate the frequency and risk factors for neonatal thyroid dysfunction following HSG. Methods: We studied 212 infants born to mothers who had become pregnant after undergoing HSG involving the use of ethiodized oil. Results: Five of the 212 infants tested positive during congenital hypothyroidism screening; this frequency (2.4%) was higher than the recall rate among first congenital hypothyroidism screening results (0.7%) in Tokyo, Japan. Two of the 5 screening-positive infants showed hypothyroidism, and 3 showed hyperthyrotropinemia. The urinary iodine concentrations in 4 out of the 5 screening-positive infants were 1,150, 940, 1,570, and 319 μg/l. The subjects were divided into thyroid dysfunction (n = 5) and normal thyroid function (n = 207) groups. The median dosage of ethiodized oil in the thyroid dysfunction group was significantly higher than in the normal thyroid function group (20 vs. 8 ml, p = 0.033). Conclusion: When infertile women undergo HSG, the dosage of oil-soluble iodinated contrast medium should be as low as possible to minimize the risk of fetal or neonatal thyroid dysfunction.

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Gestational changes of thyroid function and urinary iodine in thyroid antibody-negative Japanese women

Cited by 20 publications

References 52 publications

Women with Subclinical Hypothyroidism Are at Low Risk of Poor Pregnancy Outcome in Japan

Women with Subclinical Hypothyroidism Are at Low Risk of Poor Pregnancy Outcome in Japan

Validity and Reproducibility of the Iodine Dietary Intake Questionnaire Assessment Conducted for Young Polish Women

Thyroid Dysfunction in Neonates Born to Mothers Who Have Undergone Hysterosalpingography Involving an Oil-Soluble Iodinated Contrast Medium

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