Gestational choriocarcinoma presenting with bilateral kidney and lung metastases with unknown primary: An uncommon clinical scenario

Parajuli, Pawan; Poudyal, S; Chapagain, Suman; Luitel, Bhoj Raj; Chalise, Pawan Raj; Sharma, Uttam

doi:10.1016/j.eucr.2020.101433

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…The most common presenting symptom of choriocarcinoma is gynecologic manifestations, mainly vaginal bleeding. Sometimes, the primary uterine tumor undergoes spontaneous necrosis or complete regression and the patient presents with extra-uterine manifestations in the later period due to metastasis [ 1 ]. Overall, about one third of the patients present with non-gynecological manifestations as a result of metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Even accompanied by multiple metastases, choriocarcinoma is extremely chemosensitive and the possibility of cure remains high [ 12 ]. Cure rates of 80–90 % may be achieved when combined with adjuvant radiotherapy or surgery [ 1 ]. The options of treatment for high-risk gestational trophoblastic neoplasia with multi-agent chemotherapy include MAC (Methotrexate, Actinomycin D, Cyclophosphamide or Clorambucile) or CHAMOMA (Hydroxyurea, Actinomycin D, Methotrexate, Folinic acid, Cytoxan, Vincristine, and Adriamycin).…”

Section: Discussionmentioning

confidence: 99%

“…Choriocarcinoma is one of the malignant types of gestational trophoblastic tumors. It can also occur in a non-gestational form [ 1 ]. Gestational Trophoblastic tumors are known to arise from the trophoblastic elements of the placenta.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Choriocarcinoma metastatic to both kidneys presenting with spontaneous renal hemorrhage: Case report

Bekele,

Beyene,

Belete

et al. 2024

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Choriocarcinoma metastatic to both kidneys presenting with spontaneous renal hemorrhage: Case report

Bekele,

Beyene,

Belete

et al. 2024

International Journal of Surgery Case Reports

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Severe Disease Progression of Postmolar Gestational Neoplasm in a Vietnamese Young Female Patient After Treatment Refusal: Insights From a Case Report and Literature Review

VO,

NGUYEN

2024

Exp. oncol.

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Choriocarcinoma is characterized as the most aggressive malignant alternation of gestational trophoblastic neoplasm; however, this illness is a curable malignancy. Although a rarity, this disease affects a female patient’s life and causes a fatal condition. Choriocarcinoma is a life-threatening disease since it is initially insidious and can rapidly lead to masive hemorrhage, even death. Choriocarcinoma should be suspected in childbearing-age women with the high-risk scores according to FIGO. The study aims to report a severe case of widespread metastatic choriocarcinoma to optimize the treatment with multiagent chemotherapy and a multidisciplinary cooperation at our center. A G1P0 20-year-old woman was referred to the hospital for suspicion of metastatic choriocarcinoma after self-stopping chemotherapy because of the COVID-19 pandemic. During hospitalization, the tumor metastasized and presented profuse intraabdominal hemorrhage. The patient underwent immediate surgical intervention to control bleeding, and a definitive diagnosis was accurately established by the histopathological examination. After surgery, the EMA/CO regimen was administered as the first line of treatment, despite the patient being in a coma and requiring a ventilator machine. After 6 cycles of the EMA/CO regimen, her serum β-hCG level decreased to 8 mUI/mL, however, her β-hCG concentration was not down to a negative value. Thus, the patient received paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE regimen) for complete remission following 2 cycles. The delays in choriocarcinoma treatment are prognostic factors for worse outcomes, whereas chemotherapy may be considered a suitable treatment even in a patient’s coma, thus improving a prognosis substantially.

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Metastatic choriocarcinoma of the lung without a primary: A case report

Capelli,

Farag,

Johnson

et al. 2024

Int J Case Rep Images

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Delayed presentation of metastatic gestational choriocarcinoma is a very rare phenomenon. We report a case of a 43-year-old female who presented three years after giving birth with a right lung mass and elevated β-human chorionic gonadotropin (HCG) levels. She underwent a right thoracotomy with right lower lobe lobectomy. The final pathology revealed metastatic gestational choriocarcinoma. In these cases, resection is recommended and patients often benefit from adjuvant chemotherapy. The patient was successfully treated with resection and is currently undergoing chemotherapy treatment. A delayed presentation of metastatic gestational choriocarcinoma should be considered as a differential in women presenting with a lung mass and a history of previous pregnancy. Prompt diagnosis and treatment can improve patient outcomes.

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Gestational choriocarcinoma presenting with bilateral kidney and lung metastases with unknown primary: An uncommon clinical scenario

Cited by 3 publications

References 5 publications

Choriocarcinoma metastatic to both kidneys presenting with spontaneous renal hemorrhage: Case report

Choriocarcinoma metastatic to both kidneys presenting with spontaneous renal hemorrhage: Case report

Severe Disease Progression of Postmolar Gestational Neoplasm in a Vietnamese Young Female Patient After Treatment Refusal: Insights From a Case Report and Literature Review

Metastatic choriocarcinoma of the lung without a primary: A case report

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