Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report

Abstract

Abstract. Primary gestational choriocarcinoma is commonly present in the uterus in cases of atypical genital bleeding. Symptoms similar to those of an ectopic pregnancy develop when an extra-uterine lesion is present in the abdominal cavity, and lesions have been detected in the ovaries and fallopian tubes in a number of cases. In the present study, we describe a patient with choriocarcinoma that metastasized to the uterine serosa and caused symptoms similar to those of an ectopic pregnancy. The patient was a 30-year-old female who presented to our hospital with atypical genital bleeding and a positive pregnancy test 3 months after missed abortion at 10 weeks of gestation. Transvaginal ultrasonography revealed the absence of a gestational sac in or outside the uterus, and intra-abdominal bleeding was noted. An ectopic pregnancy was suspected based on these findings, and emergency laparotomy was performed. A hemorrhagic mass was present on the uterine serosa, and was subsequently resected. Trophoblastic disease was suspected following histopathological examination, for which intra-uterine curettage was performed and choriocarcinoma was diagnosed. Lung metastasis was detected on computed tomography, and a high serum human chorionic gonadotropin (hCG) level persisted following surgery. The lesion disappeared following five cycles of methotrexate+ etoposide+actinomycin D therapy, which was performed as postoperative chemotherapy, and the patient's serum hCG level decreased to below the detection limit. In this case of choriocarcinoma, the primary lesion was present in the uterus and had metastasized to the uterine serosa, which is a very rare metastatic site. This uterine serosal metastatic lesion bled and caused symptoms similar to those of an ectopic pregnancy. Certain patients who undergo surgery for a suspected peritoneal pregnancy may have gestational choriocarcinoma, similar to this case.

Choriocarcinoma-Driven Uterine Perforation in a Bicornuate Anatomy: An Elusive Encounter

“…Typically, choriocarcinoma disseminates extensively via hematogenous pathways, often correlating with distant metastases. A history of molar pregnancy is a prime risk factor for choriocarcinoma [5], a criterion met in the present case.…”

Uterine leiomyosarcoma mimicking chronic ruptured ectopic pregnancy

“…A rare case report by Sinha M. et al describes a case of chorioadenoma destruens mimicking ruptured ectopic pregnancy [4]. A case report by Sakamoto Y et al reported gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy [5]. Ogu RN et al has reported a case of submucous uterine fibroid mimicking ruptured ectopic gestation [6].…”

Hemoptysis as primary manifestation in three women with choriocarcinoma with pulmonary metastasis: a case series

“…Metastatic lesions may be isolated or multiple. Several miliary lesions and solitary or multiple nodules or masses can be observed and expressed as flaky, patchy, or cotton-like lesions [ 8 – 14 ]. These signs can occur alone or at the same time and can transform into each other in the development of the disease.…”