Gestational Choriocarcinoma with Varied Clinical Presentation and Treatment Outcome: A Case Series

Tamang, Tshering; Tshomo, Ugyen

doi:10.5005/jp-journals-10006-1606

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…4 In a case series of six cases, patients displayed a variety of unusual clinical manifestation including suspected pulmonary tuberculosis, lung mass, pneumonia, heavy vaginal bleeding, pelvic mass, and peritonitis that highlighted the importance of having a high degree of clinical suspicion of choriocarcinoma in women of reproductive age. 10 All their cases were with scores of 8 to 12, EMACO therapy and selective hysterectomy proved to be beneficial. Administering three cycles of consolidation chemotherapy after remission that is given every 15 days was their standard practice.…”

Section: Discussionmentioning

confidence: 93%

A Case Series of Gestational Choriocarcinoma with Review of Literature

Tanneru,

Shetty,

Nandan

2023

Indian J Med Paediatr Oncol

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Choriocarcinoma can be gestational and nongestational. Gestational choriocarcinoma is rare with an incidence of 9.2 in 40,000 pregnancies in Asian population. They can occur following molar, partial molar pregnancy, abortion, or delivery. It is detected by elevated levels of serum beta-human chorionic gonadotropin (beta-hCG) and by imaging modality. The need for histopathological diagnosis for choriocarcinoma is debatable. Six cases of choriocarcinoma are described with variable presentations and outcomes. Out of six cases, three were following vaginal delivery, two were after abortion, and one case was perimenopausal with antecedent pregnancy 10 years ago, unclear whether it was the cause for choriocarcinoma. Brain and lung metastasis were seen in three cases each; one case, which had metastasis to all organs, had worse prognosis and succumbed to the disease. All belonged to high-risk group according to International Federation of Gynaecology and Obstetrics score (8–13). The prognosis is usually very good, provided that prompt diagnosis and treatment are initiated early. Long-term follow-up with beta-hCG levels needs to be done to detect recurrence but it did not act like a prognostic indicator in our case series.

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Section: Discussionmentioning

confidence: 93%