Gestational Diabetes: A Survey and the Graz Approach to Diagnosis and Therapy

Weiss, Peter A. M.

doi:10.1007/978-3-7091-8925-2_1

Cited by 58 publications

(55 citation statements)

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“…Weiss has used third trimester amniotic fluid insulin concentration to adjust insulin treatment, demonstrating that diabetic fetopathy was found predominantly in pregnancies with amniotic fluid insulin levels two-to threefold above those in nondiabetic pregnancy (12). Weiss found that "biochemical diabetic fetopathy," defined as hypoglycemia and biochemical dysregulation in the newborn, occurred when third trimester amniotic fluid insulin levels were Ͼ17 U/ml, while "somatic fetopathy," or LGA newborns, was found only in pregnancies in which amniotic fluid insulin concentrations were Ͼ20 U/ml.…”

Section: Fetal Growth Measurementsmentioning

confidence: 99%

Modified Therapy for Gestational Diabetes Using High-Risk and Low-Risk Fetal Abdominal Circumference Growth to Select Strict Versus Relaxed Maternal Glycemic Targets

Kjos

Schaefer-Graf

2007

Diabetes Care

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Section: Fetal Growth Measurementsmentioning

confidence: 99%

Modified Therapy for Gestational Diabetes Using High-Risk and Low-Risk Fetal Abdominal Circumference Growth to Select Strict Versus Relaxed Maternal Glycemic Targets

Kjos

Schaefer-Graf

2007

Diabetes Care

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“…Schwangerschaftswoche eine ambulante Amniozen tese zur Fruchtwasserinsulinbestimmung und gleichzeitig eine fetale Biometrie sowie eine Bestimmung der mütterlichen Hämoglobin-Ai (HbA|C )-und Fruktosaminkonzentration durchgeführt wurde. Es handelte sich um 16 insulinbedürftige Gestationsdiabctikcrinnen [9] sowie um 46 insulinpflichtige Diabetikerinnen der Klasse B, 30 der Klasse C und 10 der Klasse D nach der White-Klassifikation [10].…”

Section: Materials Und Methodeunclassified

Fetale Ultraschallbiometrie und Fruchtwasserinsulinkonzentration bei diabetischen Schwangeren

Hüttner

Kainer²,

Weiss³

et al. 1997

Gynäkol Geburtshilfliche Rundsch

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Fragestellung: Das Ziel der Studie war es, die Sensitivität biometrischer Masse für das Vorliegen eines fetalen Hyperinsulinismus zu prüfen. Methoden: In einer longitudinalen Untersuchung an 102 insulinpflichtigen Diabetikerinnen wurde die Korrelation zwischen Fruchtwasserinsulinwerten und dem biparietalen Durchmesser, dem abdominellen Querdurchmesser und der Feraurlänge im 3. Trimester geprüft. Die Qualitätskontrolle des mütterlichen Stoffwechsels erfolgte durch die Bestimmung von glykosyliertem Hämoglobin (HbAιc) und Fruktosamin zum Zeitpunkt der Amniozentesen. Ergebnisse: Die Sensitivität, Spezifität sowie der positive und negative Vorhersagewert biometrischer Masse > 75. Perzentile für einen fetalen Hyperinsulinismus war für den biparietalen Durchmesser 21 96, 81 und 62%, für den abdominellen Querdurchmesser 48, 82, 69 und 66%, und für die Femurlänge 22, 90, 67 und 57%. Die maternalen Glykoproteine (HbAlc, Fruktosamin) zeigten keine Korrelation zur Fruchtwasserinsulinkonzentration. Schlussfolgerungen: Die Ergebnisse zeigen, dass der Nachweis eines fetalen Hyperinsulinismus anhand mütterlicher Stoffwechselparameter oder fetaler biometrischer Masse unzuverlässig ist.

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“…Seventy-fi ve grams of glucose was administered orally in the morning after an overnight fast of at least 12 h. Glucose was measured in venous whole blood in the fasted state and at 60 min after the oral intake of glucose. The test was considered abnormal if the venous plasma glucose values exceeded 6 160 mg/dl or 8.9 mmol/l at 60 min [20] .…”

Section: Methodsmentioning

confidence: 99%

“…All women were tested for IGT by a 75 g oral glucose tolerance test (OGTT) according to the criteria of Weiss [20] . GDM was diagnosed in 208 patients (mean age: 30.2 8 1.01, range: 17-41), of whom 26 (12.6%) had a family history of diabetes.…”

Section: Methodsmentioning

confidence: 99%

Increased C282Y Heterozygosity in Gestational Diabetes

et al. 2005

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Background: Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism that is characterized by excess accumulation of iron in various organs and often leads to diabetes mellitus (DM). To study whether mutations in the hemochromatosis gene (HFE) could be a risk factor for the development of gestational diabetes mellitus (GDM), the prevalence of HFE mutations in patients with GDM was compared to that of healthy pregnant controls. Methods: GDM was diagnosed in 208 of 2,421 pregnant woman screened between the 24th and 28thweek of gestation over a period of 18 months. Patients and 170 matched control subjects were screened for the HFE gene mutations C282Y and H63D. Results: In North and Central European GDM patients, the allele frequency of the C282Y mutation (7.7%) was higher than in pregnant controls (2.9%; p = 0.04), while the frequency of the H63D mutation was not different (p = 0.45). Three patients with GDM were homozygous for H63D (3.1%), 1 patient was homozygous for C282Y (1.0%), 2 patients were compound heterozygous (2.0%) and 26 were heterozygous [11 C282Y (11.2%) and 15 H63D (15.3%)]. C282Y and H63D allele frequencies were not different between controls and GDM patients of Southern European or non-European origin. Irrespective of the HFE-mutation status, serum ferritin levels were increased in patients with GDM compared to healthy pregnant controls (p = 0.01), while transferrin saturation was similar in both groups. Conclusions: In North and Central European patients with GDM, the C282Y allele frequency is higher than in healthy pregnant women, suggesting a genetic susceptibility to the development of GDM.

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Gestational Diabetes: A Survey and the Graz Approach to Diagnosis and Therapy

Cited by 58 publications

References 0 publications

Modified Therapy for Gestational Diabetes Using High-Risk and Low-Risk Fetal Abdominal Circumference Growth to Select Strict Versus Relaxed Maternal Glycemic Targets

Modified Therapy for Gestational Diabetes Using High-Risk and Low-Risk Fetal Abdominal Circumference Growth to Select Strict Versus Relaxed Maternal Glycemic Targets

Fetale Ultraschallbiometrie und Fruchtwasserinsulinkonzentration bei diabetischen Schwangeren

Increased C282Y Heterozygosity in Gestational Diabetes

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