Gestational diabetes and risk of incident primary cancer: a large historical cohort study in Israel

Sella, Tal; Chodick, Gabriel; Barchana, Micha; Heymann, Anthony; Porath, Avi; Kokia, Ehud; Shalev, Varda

doi:10.1007/s10552-011-9825-5

Cited by 38 publications

(44 citation statements)

References 44 publications

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“…After having followed for 28-40 years, they found 5 new pancreatic cancer cases in women with GDM history and 49 without the history; the hazard ratio (HR) of GDM history was 7.1 (2.8-18.0) after adjusted for age at first observed birth and birth weight. Similar result was also observed in a recent cohort of 185315 women by Sella et al (2011). After average follow-up period of 5.19 years, they revealed an adjusted HR of GDM history versus non-GDM history as 7.06 (1.69-29.45).…”

Section: Gdm and Other Types Of Cancersupporting

confidence: 87%

Association Between Gestational Diabetes Mellitus and Subsequent Risk of Cancer: a Systematic Review of Epidemiological Studies

Tong

Cheng²,

Chai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: This study aimed at summarizing epidemiological evidence of the association between gestational diabetes mellitus (GDM) and subsequent risk of cancer. Materials and Methods: We searched Medline, Embase, Cancer Lit and CINAHL for epidemiological studies published by February 1, 2014 examining the risk of cancer in patients with history of GDM using highly inclusive algorithms. Information about first author, year of publication, country of study, study design, cancer sites, sample sizes, attained age of subjects and methods used for determining GDM status were extracted by two researchers and Stata version 11.0 was used to perform the meta-analysis and estimate the pooled effects. Results: A total of 9 articles documented 5 cohort and 4 casecontrol studies containing 10,630 cancer cases and 14,608 women with a history of GDM were included in this review. Taken together, the pooled odds ratio (OR) between GDM and breast cancer risk was 1.01 (0.87-1.17); yet the same pooled ORs of case-control and cohort studies were 0.87 (0.71-1.06) and 1.25 (1.00-1.56) respectively. There are indications that GDM is strongly associated with higher risk of pancreatic cancer (HR=8.68) and hematologic malignancies (HR=4.53), but no relationships were detected between GDM and other types of cancer. Conclusions: Although GDM increases the risk of certain types of cancer, these results should be interpreted with caution becuase of some methodological flaws. The issue merits added investigation and coordinated efforts between researchers, antenatal clinics and cancer treatment and registration agencies to help attain better understanding.

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Section: Gdm and Other Types Of Cancersupporting

confidence: 87%

Association Between Gestational Diabetes Mellitus and Subsequent Risk of Cancer: a Systematic Review of Epidemiological Studies

Tong

Cheng²,

Chai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Odds ratio increased risk point estimate (Troisi et al 1998, Lawlor et al 2004, Perrin et al 2008 and one study reporting a negative risk point estimate (Sella et al 2011). The pooled OR did not find any association between gestational diabetes and BC (OR 1.06, 95% CI 0.79-1.40) while significant heterogeneity was present (I 2 Z68.81, PZ0.01).…”

Section: Study Name Statistics For Each Study Odds Ratio and 95%cimentioning

confidence: 74%

“…Gestational diabetes has been found to be protective in one study (Rollison et al 2008) while other studies reported an increased risk (Perrin et al 2008) or no association between the two (Troisi et al 1998, Lawlor et al 2004, Sella et al 2011). This discrepancy is also present within studies investigating type 2 diabetes mellitus and studies investigating the aetiology of BC in males.…”

Section: Introductionmentioning

confidence: 91%

“…Fourteen studies reported a statistically significant increase in BC incidence in patients with diabetes mellitus (Goodman et al 1997, Sinagra et al 2002, Michels et al 2003 Troisi et al 1998, Weiss et al 1999, Baron et al 2001, Mink et al 2002, Lawlor et al 2004, Khan et al 2006, Garmendia et al 2007, Sellers et al 2007, Perrin et al 2008, Sanderson et al 2010, Lambe et al 2011, Carstensen et al 2012, Cleveland et al 2012, Yu et al 2012 while six studies favoured a decreased risk (Moseson et al 1993, Inoue et al 2006, Rollison et al 2008, La Vecchia et al 1994, Sella et al 2011, Chlebowski et al 2012. Three studies found no association between the two (Franceschi et al 1990, Chodick et al 2010, Bowker et al 2011.…”

Section: Non-specific Diabetes Mellitusmentioning

confidence: 99%

“…Six studies were identified investigating the effect of gestational diabetes on BC incidence (Troisi et al 1998, Lawlor et al 2004, Perrin et al 2008, Rollison et al 2008, Sella et al 2011. There was a degree of heterogeneity within the results with only one study reaching statistical significance (Rollison et al 2008).…”

Section: Gestational Diabetesmentioning

confidence: 99%

See 2 more Smart Citations

Diabetes increases the risk of breast cancer: a meta-analysis

Hardefeldt

Edirimanne

Eslick

2012

Endocrine-Related Cancer

134

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The aim of this meta-analysis was to collate and analyse all primary observational studies investigating the risk of breast cancer (BC) associated with diabetes. In addition, we aimed to complete subgroup analyses by both type of diabetes and gender of study participants to further clarify the origin of any such association between the two. Studies were obtained from a database search of MEDLINE, EMBASE, PubMed, Current Contents Connect and Google Scholar with additional cross-checking of reference lists. Collated data were assessed for heterogeneity and a pooled odds ratio (OR) calculated. Forty-three studies were included in the meta-analysis with 40 studies investigating BC in women and six studies investigating BC in men. Overall, we found a significantly increased risk of BC associated with diabetes in women (OR 1.20, 95% confidence interval (CI) 1.13-1.29). After subgroup analysis by type of diabetes, the association was unchanged with type 2 diabetes (OR 1.22, 95% CI 1.07-1.40) and nullified with gestational diabetes (OR 1.06, 95% CI 0.79-1.40). There were insufficient studies to calculate a pooled OR of the risk of BC associated with type 1 diabetes. There was an increased risk of BC in males with diabetes mellitus; however, the results did not reach statistical significance (OR 1.29, 95% CI 0.99-1.67). In conclusion, diabetes increases the risk of BC in women. This association is confirmed in women with type 2 diabetes and supports the hypothesis that diabetes is an independent risk factor for BC.

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Mother‐child cardiometabolic health 4–10 years after pregnancy complicated by obesity with and without gestational diabetes

Martin

Zhang

Callahan

et al. 2022

Obesity Science & Practice

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Objective Obesity in pregnancy and gestational diabetes (GDM) increase cardiometabolic disease risk but are difficult to disentangle. This study aimed to test the hypothesis that 4–10 years after a pregnancy complicated by overweight/obesity and GDM (OB‐GDM), women and children would have greater adiposity and poorer cardiometabolic health than those with overweight/obesity (OB) or normal weight (NW) and no GDM during the index pregnancy. Methods In this cross‐sectional study, mother‐child dyads were stratified into three groups based on maternal health status during pregnancy (OB‐GDM = 67; OB = 76; NW = 76). Weight, height, waist and hip circumferences, and blood pressure were measured, along with fasting glucose, insulin, HbA1c, lipids, adipokines, and cytokines. Results Women in the OB and OB‐GDM groups had greater current adiposity and poorer cardiometabolic health outcomes than those in the NW group (p < 0.05). After adjusting for current adiposity, women in the OB‐GDM group had higher HbA1c, glucose, HOMA‐IR and triglycerides than NW and OB groups (p < 0.05). Among children, adiposity was greater in the OB‐GDM versus NW group (p < 0.05), but other indices of cardiometabolic health did not differ. Conclusions Poor cardiometabolic health in women with prior GDM is independent of current adiposity. Although greater adiposity among children exposed to GDM is evident at 4–10 years, differences in cardiometabolic health may not emerge until later.

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Gestational diabetes and risk of incident primary cancer: a large historical cohort study in Israel

Abstract: GDM is associated with an increased risk of pancreatic cancer and hematologic malignancies.

Cited by 38 publications

References 44 publications

Association Between Gestational Diabetes Mellitus and Subsequent Risk of Cancer: a Systematic Review of Epidemiological Studies

Association Between Gestational Diabetes Mellitus and Subsequent Risk of Cancer: a Systematic Review of Epidemiological Studies

Diabetes increases the risk of breast cancer: a meta-analysis

Mother‐child cardiometabolic health 4–10 years after pregnancy complicated by obesity with and without gestational diabetes

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