2022
DOI: 10.3389/fendo.2022.916042
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Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis?

Abstract: Gestational diabetes mellitus (GDM), is one of the most important pregnancy complications affecting approximately 15% of pregnant women. It is related to several gestational adverse outcomes in the fetus, e.g., macrosomia, shoulder dystocia, stillbirth, neonatal hypoglycemia, and respiratory distress. Women with GDM have a high risk of developing type 2 diabetes in the future. The pathogenesis of GDM is not completely understood; nevertheless, two factors could contribute to its development: β-cell dysfunction… Show more

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Cited by 17 publications
(14 citation statements)
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References 115 publications
(159 reference statements)
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“…The change in plasma insulin levels from baseline to 1h (delta insulin 0–60 minutes) appeared to be inversely associated with the IGFBP1 levels at 1h (r= −0.39; P = 0.047) and at 2h (r= −0.31; P = 0.11) during the OGTT. This is consistent with the known negative feedback regulation of IGFBP1 expression by insulin, albeit only shown in hepatocytes 20 .…”
Section: Resultssupporting
confidence: 90%
See 3 more Smart Citations
“…The change in plasma insulin levels from baseline to 1h (delta insulin 0–60 minutes) appeared to be inversely associated with the IGFBP1 levels at 1h (r= −0.39; P = 0.047) and at 2h (r= −0.31; P = 0.11) during the OGTT. This is consistent with the known negative feedback regulation of IGFBP1 expression by insulin, albeit only shown in hepatocytes 20 .…”
Section: Resultssupporting
confidence: 90%
“…Functional studies suggest that IGFBP1 binds IGF-1 and IGF-2 with equal affinity and can either inhibit or enhance IGF actions, depending on the context 20 . In post-natal life, IGF-1 is the main active growth factor and is essential for normal growth during childhood and adolescence; while during fetal development, both IGF-1 and IGF-2 are key regulators of fetal growth 20 . Outside of pregnancy, IGF-1 enhances insulin sensitivity by suppressing hepatic glucose production 27 , 28 and promoting glucose uptake in peripheral tissues 29 , 30 .…”
Section: Discussionmentioning
confidence: 99%
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“…Similar to type 2 diabetes mellitus (T2DM), GDM is also a multifactorial disease whose pathogenesis is not fully understood. But, dysfunction of β-cells and failure of insulin secretion in response to pregnancy-induced insulin resistance have been shown to be likely key factors leading to GDM [ 11 ].…”
Section: Physiopathology Of Gdmmentioning
confidence: 99%