Gestational diabetes mellitus and inflammatory biomarkers of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio: a systematic review and meta-analysis

Hessami, Kamran; Tabrizi, Reza; Homayoon, Nahid; Hashemi, Atefe; Heydari, Seyed Taghi; Pourhoseini, Seyedeh Azam

doi:10.1080/1354750x.2021.1926542

Cited by 20 publications

(11 citation statements)

References 28 publications

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“…Abnormal increases in neutrophil count, WBC count, neutrophilto-lymphocyte ratio (NLR), and mean platelet volume are commonly observed as simple markers of inflammation as they are known to function as inflammatory blood cell parameters [72][73][74]. In various chronic sub-inflammatory states, neutrophils constitute the largest proportion of WBC [75,76].…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Dietary Inflammatory Index and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database

Zeng,

Piao

2024

Exp Clin Endocrinol Diabetes

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Objective This study focused on the association of the Dietary Inflammatory Index (DII) with the risk of gestational diabetes mellitus (GDM) using data from the National Health and Nutrition Examination Survey (NHANES). Methods Data from two cycles of NHANES (2007–2010) were analyzed. Weighted logistic regression models were constructed to explore the relationship between DII and GDM. Stratified and subgroup analyses with adjustment for confounding factors were carried out to explore the association between DII and GDM. Mediation analysis was conducted to investigate potential mediating factors. Results A total of 1,421 samples were analyzed. Based on the weighted logistic regression model, a strong positive association was observed between DII score and GDM risk (OR: 1.14, 95%CI: 1.02–1.26, P<0.01), suggesting that a pro-inflammatory diet could considerably increase the likelihood of GDM occurrence. This positive association was particularly significant in populations who consume alcohol (OR:1.17, 95%CI: 1.03–1.34, P<0.01) and have a body mass index>30 kg/m² (OR: 1.18, 95% CI: 1.01–1.38, P<0.05). Mediation analysis indicated that the white blood cell count mediated the association between DII and GDM, with an indirect effect of 0.000828 (95% CI: 0.000226–0.001347, P=0.001) and a mediation proportion of 8.01%. Specifically, the neutrophil count as a component contributed to this mediation effect (0.000774, 95% CI: 0.00014–0.001063, P=0.001), with a mediation proportion of 7.59%. Conclusion A pro-inflammatory diet in women elevates the likelihood of GDM occurrence. An anti-inflammatory dietary pattern may be a protective intervention for GDM.

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Section: Discussionmentioning

confidence: 99%

Association Analysis of Dietary Inflammatory Index and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database

Zeng,

Piao

2024

Exp Clin Endocrinol Diabetes

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“…PLR demonstrated limited sensitivity but acceptable specificity, indicating moderate accuracy in preeclampsia diagnosis [30]. The same inflammatory biomarkers (NLR and PLR) were evaluated in pregnancies complicated by gestational diabetes [31]. A correlation between inflammatory markers, specifically NLR, and the diagnosis of gestational diabetes mellitus was recognized [32].…”

Section: Discussionmentioning

confidence: 99%

Postpartum Depression and Inflammatory Biomarkers of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Monocyte-Lymphocyte Ratio: A Prospective Observational Study

La Verde,

Luciano,

Fordellone

et al. 2024

Gynecol Obstet Invest

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Objectives: Postpartum depression (PPD) is a severe mental health disorder affecting a significant proportion of mothers, often undiagnosed and untreated, with potential long-term effects. While numerous studies have identified risk factors for PPD, the relationship between inflammatory markers and PPD remains unknown. This study aimed to investigate the potential correlation between indirect inflammatory markers, specifically neutrophil-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR), and the risk of developing PPD, assessed by the Edinburgh Postnatal Depression Scale (EPDS). Design: This was a prospective observational study conducted in a second-level university hospital, from December 2019 to February 2021. Participants: A total of 211 full-term pregnant women were enrolled. Exclusion criteria included specific psychiatric diagnoses, such as severe intellectual disability, schizophrenia, schizoaffective disorder, delusional disorder, bipolar or other unspecified psychotic spectrum disorders. Additionally, pregnancies affected by gestational and pregestational diabetes, chronic hypertension, gestational hypertension, preeclampsia/eclampsia, intrauterine fetal growth restriction, preterm delivery, multiple pregnancies, and fetal abnormalities detected prenatally were excluded. Methods: Socio-demographic and clinical data were recorded. Blood samples for complete blood count were obtained at hospital admission, focusing on NLR, PLR, and MLR. Analyses were conducted in our laboratory using standard techniques. The postpartum PPD evaluation was conducted 3 days after delivery, with the EPDS Italian version. Statistical analyses included descriptive statistics, group comparisons using t tests or Wilcoxon rank-sum tests for continuous variables, and Pearson χ2 or Fisher’s exact tests for categorical variables. Correlation analyses employed Pearson correlation or Spearman’s rank correlation tests. Simple logistic regression models, adjusted for various baseline patient characteristics, explored the correlation between inflammatory markers (PLR, NLR, MLR) and postpartum depressive symptoms. Version 4.1.3 of RStudio statistical software was utilized. Results: Overall, 211 pregnant women enrolled were categorized into two groups based on the EPDS scores: <10 (176 patients) and ≥10 (35 patients). The two groups demonstrated homogeneity in different socio-demographic factors. Stepwise regression analysis indicated that PLR, NLR, and MLR were not significantly associated with these variables. The scatterplot of PLR, NLR, and MLR on EPDS was stratified for EPDS groups. The Wilcoxon rank-sum test applied to PLR, NLR, and MLR values and EPDS groups did not reveal a statistical relationship. Additional analyses were conducted using the estimated odds ratios of the logistic regression model on EPDS groups, considering both continuous and binary values of indirect inflammatory markers (PLR, NLR, MLR). The results indicated the absence of a statistical relationship. Limitations: Our evaluation was restricted to the postpartum period, and data for the first and second trimesters of pregnancy are lacking. Conclusions: Our findings did not evidence a correlation between indirect inflammatory markers (NLR, PLR, and MPL) and PPD. This novel finding prompts further evaluation of the role of indirect inflammatory markers in PPD, highlighting the need for additional research to clarify the complex relationship between inflammation and psychological health in the postpartum period.

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“…Furthermore, NIM has also exhibited significant associations with other metabolic disorders. The results of a meta-analysis including 16 studies showed that pregnant women with gestational diabetes mellitus (GDM) had significantly higher levels of NLR compared with those without GDM [27]. The presence of an elevated NLR has also been observed to be associated with suboptimal glycaemic control in patients with DM [28].…”

Section: Discussionmentioning

confidence: 99%

Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study

Wang,

Zhao,

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Objective This study aimed to investigate the association between novel inflammatory markers (NIMs) and non-alcoholic fatty liver disease (NAFLD). Methods A total of 6306 subjects were enrolled in this cross-sectional study. NIMs, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein to albumin ratio (CAR), lymphocyte to monocyte ratio (LMR), systemic immune-inflammation index (SII) and prognostic nutritional index (PNI), were calculated. The prevalence of NAFLD and its association with NIMs were assessed by multivariable logistic regression analysis. Subgroup analysis were performed based on age, sex and BMI. Results The prevalence of NAFLD was 52.5% in the study population. Compared with non-NAFLD subjects, NAFLD patients were older and more frequent in females. The prevalence of NAFLD progressively increased among the higher quartile groups of CAR, LMR, SII and PNI (P-trend < 0.05), whereas it progressively decreased among the higher quartile group of NLR and PLR (P-trend < 0.05). According to multivariable logistic regression analysis, the highest quartile (Q4) had a significantly higher risk of NAFLD compared with Q1 in LMR [odds ratio (OR): 1.43; 95% confidence interval (CI): 1.17–1.75; P-trend < 0.001] and PNI (OR: 1.92; 95% CI: 1.57–2.35; P-trend < 0.001). The subgroup analysis showed a stronger association of PNI with NAFLD. Conclusion The study highlights the association between NIMs and NAFLD, with LMR and PNI identified as potential non-invasive markers of inflammation in NAFLD. Specifically, PNI exhibited the strongest association and may serve as a valuable marker for assessing inflammation in NAFLD.

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Gestational diabetes mellitus and inflammatory biomarkers of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio: a systematic review and meta-analysis

Cited by 20 publications

References 28 publications

Association Analysis of Dietary Inflammatory Index and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database

Association Analysis of Dietary Inflammatory Index and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database

Postpartum Depression and Inflammatory Biomarkers of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Monocyte-Lymphocyte Ratio: A Prospective Observational Study

Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study

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