Gestational diabetes mellitus in Korea: prevalence and prediction of glucose intolerance at early postpartum

Jang, Hak Chul; Yim, Chang Hoon; Han, Kyoung-Sik; Yoon, Hyun Sik; Han, In K.; Kim, Moon Young; Yang, Jae Hyug; Cho, Nam H.

doi:10.1016/s0168-8227(03)00110-4

Cited by 57 publications

(56 citation statements)

References 18 publications

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Section: Diabetes Care 28:2750 -2755 2005mentioning

confidence: 99%

“…Studies in Western populations have found conversion rates from 3 to 38% within the 1st year postpartum (6 -8). Although a limited number of such studies have been performed in Asian countries, studies in Hong Kong and Korea found a 20 and 38.3% prevalence, respectively, of impaired glucose metabolism in the early postpartum period (9,10).…”

Section: G Estational Diabetes Mellitus (Gdm)mentioning

confidence: 99%

“…Metabolic factors that predict risk of diabetes after GDM have also been identified. A high fasting glucose level during pregnancy, impaired ␤-cell function, and the presence of islet cell antibodies are associated with the postpartum development of diabetes (10,14,15).During the past 2 decades, hyperhomocysteinemia has emerged as a risk factor for cardiovascular diseases (16). Detrimental effects of homocysteine on endothelial function are well documented (17,18).…”

mentioning

confidence: 99%

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Elevated Homocysteine as a Risk Factor for the Development of Diabetes in Women With a Previous History of Gestational Diabetes Mellitus

et al. 2005

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OBJECTIVE -To investigate the potential use of the plasma homocysteine level as a predictor of diabetes in women with a previous history of gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODS -At 6 weeks' postpartum, baseline examination was performed in 177 GAD-negative subjects. Of these subjects, 7 who were diagnosed with diabetes at baseline were excluded from further evaluation, and 170 with normal or impaired glucose tolerance (IGT) at baseline were followed annually over 4 years. The follow-up examinations included 2-h 75-g oral glucose tolerance tests (OGTTs), lipid profiles, homocysteine levels, anthropometric measurements, history taking, diet, and lifestyle. During the OGTTs, insulin and glucose levels were assayed every 30 min. Plasma homocysteine levels were determined by ion-exchange chromatography.RESULTS -Of the 170 women, 18 (10.6%) converted to diabetes during the 4-year follow-up period. Mean age, BMI, fasting insulin, and total cholesterol at baseline (6 weeks' postpartum test) were similar in the three study groups (i.e., normal, IGT, and diabetes). Fasting glucose levels, insulin-to-glucose ratios, and homocysteine levels were significantly higher in the diabetic group (P Ͻ 0.05). Higher glucose at the time of the diagnosis of GDM and higher homocysteine levels at baseline were independently associated with the onset of postpartum diabetes. These relationships were independent of age, BMI, and family history of diabetes.CONCLUSIONS -This prospective study identified homocysteine level as a significant risk factor for development of diabetes in women with previous GDM. Diabetes Care 28:2750 -2755, 2005G estational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity first recognized in pregnancy (1). GDM may complicate as many as 3-8% of all pregnancies in North America (2). Although the reported prevalence of GDM seems to be slightly lower in Asian countries (3,4), adverse outcomes are very similar in these two regions. Furthermore, women with GDM are at increased risk of later development of type 2 diabetes (5). Studies in Western populations have found conversion rates from 3 to 38% within the 1st year postpartum (6 -8). Although a limited number of such studies have been performed in Asian countries, studies in Hong Kong and Korea found a 20 and 38.3% prevalence, respectively, of impaired glucose metabolism in the early postpartum period (9,10).More than 4 decades ago, Wilkerson, O'Sullivan, and Mahan (5,11) initiated studies on glucose intolerance during pregnancy in an effort to identify women at risk of subsequent development of diabetes. The following clinical characteristics are reported to be key risk factors for development of diabetes postpartum: insulin requirement during pregnancy, earlier diagnosis of GDM during pregnancy, family history of diabetes, recurrence of GDM, increasing parity, maternal age, prepregnancy obesity, weight gain during pregnancy, and a previous macrosomic infant (12,13). Metabolic factors that predict risk of di...

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Section: Diabetes Care 28:2750 -2755 2005mentioning

confidence: 99%

Section: G Estational Diabetes Mellitus (Gdm)mentioning

confidence: 99%

mentioning

confidence: 99%

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Elevated Homocysteine as a Risk Factor for the Development of Diabetes in Women With a Previous History of Gestational Diabetes Mellitus

et al. 2005

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“…The frequency of GD significantly increases with increasing number of risk factors. However, even a combination of risk factors does not reliably predict the likelihood of developing GD, missing up to 50% of cases in population based studies (Fraser & Heller, 2007;Jang et al, 2003) estimates that if age > 30 years, obesity (BMI > 27.3), family history of diabetes mellitus and glycosuria in the present pregnancy were included as risk factors, 56.5% of the total population had risk factors for GD. However, in the stated report, the prevalence of GD in Korea was 2.0%, Thailand -2.0% and U.S. Caucasians -2.3%.…”

Section: Risk Factors For Gdmentioning

confidence: 99%

Prevalence and Risk Factors for the Development of GD in Some Eastern European Countries – Tendencies and Pharmacoeconomical Assessment for the Choice of Treatment

Petkova¹,

Nikolova²

2011

Gestational Diabetes

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“…특히 임신성 당뇨병으로 진단되었던 이후에 제2형 당뇨 병으로 진행되는 경우가 외국에서는 2.6~70% [1], 한국 인에서는 30% 이상에서 보고되고 있으며 [7], 임신성 당 뇨병이 제2형 당뇨병으로 진행하는데는 임신 기간 동안 의 치료 유무, 베타세포의 기능, 산모의 나이 및 체질량 지수 등이 위험인자로서 알려져 있다 [8]. 최근에도 임신 성 당뇨병의 경력이 있던 산모가 추후 제2형 당뇨병으 로 진행하는 것을 미리 예측할 수 있는 지표에 대해 많 은 연구가 이루어 지고 있는데, 이 중 지단백의 전반적 인 상승은 정상 임신 상태에서도 호르몬의 영향으로 일 어나지만, 임신성 당뇨병 환자에서는 아직까지 여러가 지 의견이 있다 [9][10][11].…”

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Risk Factors for Progression to Postpartum Diabetes Mellitus and Perinatal Complications in Women with Gestational Diabetes Mellitus

Kim

Chun

Jang³

et al. 2014

J Korean Diabetes

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Background: Gestational diabetes mellitus (GDM) is a hyperglycemic condition caused by increased insulin resistance and impaired insulin secretion during pregnancy. It is known to be temporary, but it can cause perinatal complications in the mother and baby. Additionally, it may progress to type 2 diabetes mellitus (T2DM). In the present study, we evaluated the risk factors for complications and progression to T2DM in patients with GDM. Methods: The study included 130 pregnant women who were diagnosed with GDM at gestational weeks 24-28 in 2011. Body mass index and the levels of glucose, total cholesterol, lipoproteins, and coagulation factors (von Willebrand factor and plasminogen activator inhibitor-1) were assessed in all patients. Results: The level of high-density lipoprotein (HDL) was significantly lower and the triglyceride/HDL ratio and coagulation factor levels were significantly higher in the group of patients with perinatal complications compared to those in the group of patients without complications. After delivery, the level of HDL was lower and the value of homeostasis model assessment of insulin resistance (HOMA-IR) was higher in women with impaired glucose metabolism compared to those in women with normal glucose metabolism. In logistic regression analysis, perinatal complications were independently associated with HDL and PAI-1 levels (OR = 0.929 and 1.101, respectively). Conclusion: The findings of our study show that the levels of HDL and coagulation factors are notable risk factors of perinatal complications. Additionally, we showed that lower HDL level may influence the progression to T2DM. Large-scale population studies are needed to verify our findings. (

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Gestational diabetes mellitus in Korea: prevalence and prediction of glucose intolerance at early postpartum

Cited by 57 publications

References 18 publications

Elevated Homocysteine as a Risk Factor for the Development of Diabetes in Women With a Previous History of Gestational Diabetes Mellitus

Elevated Homocysteine as a Risk Factor for the Development of Diabetes in Women With a Previous History of Gestational Diabetes Mellitus

Prevalence and Risk Factors for the Development of GD in Some Eastern European Countries – Tendencies and Pharmacoeconomical Assessment for the Choice of Treatment

Risk Factors for Progression to Postpartum Diabetes Mellitus and Perinatal Complications in Women with Gestational Diabetes Mellitus

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