Gestational diabetes mellitus in women with multiple pregnancies: is the metabolic abnormality milder?

Abstract

In this cohort of women with GDM, those with MP did not demonstrate a lesser degree of dysglycemia after controlling for other pregnancy characteristics and pregnancy-independent factors.

Developing twin‐specific 75‐g oral glucose tolerance test diagnostic thresholds for gestational diabetes based on the risk of future maternal diabetes: a population‐based cohort study

“…We identified only two prior studies that addressed this question; these provided conflicting results. 23,24 It is likely that, due to the greater pregnancy-related increase in insulin resistance in twin compared with singleton pregnancies, women with twins can develop GDM in the presence of milder degrees of beta-cell dysfunction than those associated with GDM in singleton pregnancies. 2,3 Therefore, the diagnosis of GDM in twin pregnancies does not reflect the same degree of predisposition for future T2DM as that associated with the diagnosis of GDM in singleton pregnancies.…”

“…Women with GDM in a twin pregnancy in the current study were less likely to develop T2DM compared with women with GDM in a singleton pregnancy. We identified only two prior studies that addressed this question; these provided conflicting results 23,24 . It is likely that, due to the greater pregnancy‐related increase in insulin resistance in twin compared with singleton pregnancies, women with twins can develop GDM in the presence of milder degrees of beta‐cell dysfunction than those associated with GDM in singleton pregnancies 2,3 .…”