Gestational diabetes mellitus induces placental vasculopathies

Aldahmash, Waleed; Alwasel, Saleh; Aljerian, Khaldoon

doi:10.1007/s11356-021-17267-y

Cited by 20 publications

(13 citation statements)

References 36 publications

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“…28 Fibromuscular sclerosis is seen more in patients with GDM, however, our study showed a higher incidence in mothers who give birth to low-birthweight babies. 29 Our study showed focal hyaline degeneration, focal avascular villi, increased syncytial knotting, and fibromuscular sclerosis to be significantly associated with low-birth-weight babies, however, in a study conducted in Uttar Pradesh showed that placental ischemia, placental infarction, fibrinoid necrosis, stromal fibrosis, and calcification were significantly associated with low-birth-weight babies. 8 In our study, the placental diameter and volume had a moderate positive correlation with birth weight of the baby in both case and control groups similar to other studies conducted in Karnataka.…”

Section: Discussioncontrasting

confidence: 80%

Association of Placental Risk Factors and Birth Weight of Newborn: A Case–Control Study

Patil¹,

Balasubramanian²,

Baliga³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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Introduction: The global incidence of low birth is 15%, and in India, it is 18%. Together with gestational maternal age and size, placental factors contribute to 32% of low-birth weight. Various factors influence the fetal growth such as the factors originating from fetus itself, maternal factors, placental factors, and the factors due to interaction of all these factors. Materials and methods: The placenta was collected from 30 mothers of low-birth-weight babies and 60 placentas from mothers of normalbirth-weight babies in the Department of Obstetrics and Gynecology from October 2020 to December 2020. Information regarding maternal characteristics, placental morphometry, and newborn parameters were recorded. Results: Mean of placental weight is significantly less in case group (420 + 7 gm) compared with control (560 + 100) group. Mean of placental length, breadth, surface area, diameter, and thickness is significantly less in the case group compared with the control group (p <0.05). The presence of hard areas, focal avascular villi, syncytial knotting, focal hyaline degeneration, and fibromuscular sclerosis was seen more in lowbirth-weight babies when compared with normal-birth-weight babies (p <0.05). Conclusion: Placental factors such as placental weight, placental length, breadth, diameter, surface area, thickness, and volume were less in low-birth-weight babies. All the microscopic and gross findings like the presence of hard areas, focal avascular villi, syncytial knotting, focal hyaline degeneration, and fibromuscular sclerosis were seen more in low-birth-weight babies.

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Section: Discussioncontrasting

confidence: 80%

Association of Placental Risk Factors and Birth Weight of Newborn: A Case–Control Study

Patil¹,

Balasubramanian²,

Baliga³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…CD248 is required for pathological and developmental angiogenesis [43, 44]. Previous studies have indicated that placental vascular lesions such as chorangiosis, decidual vasculopathy, and villous fibrinoid necrosis were significant in patients with GDM [45, 46]. In the present study, CD248 was decreased in the placentas of patients with GDM compared to in those of normal pregnant women, which may be related to angiogenesis and blood vessel remodeling.…”

Section: Discussionsupporting

confidence: 54%

Placental and plasma early predictive biomarkers for gestational diabetes mellitus

Wei

Huang

et al. 2022

Proteomics Clinical Apps

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Purpose Gestational diabetes mellitus (GDM) is a common disease that can give rise to adverse obstetric outcomes. For successful early intervention, more studies on novel predictive biomarkers for GDM are required. Experimental Design The protein expression profiles of placental tissue from patients with GDM and normal pregnant women were investigated using data‐independent acquisition proteomics with five biological replicates. Early pregnancy maternal plasma samples from the GDM (n = 79) and control (n = 81) groups were used for further validation of candidate biomarkers. Results We identified 37 differentially expressed proteins between the two groups. CD109 antigen (CD109) and endosialin (CD248) were identified as hub proteins. In the validation experiments, CD109 expression was lower in the early pregnancy maternal plasma of patients with GDM compared with that in normal pregnant women, and CD248 expression was higher in the GDM group. The area under the curve of CD109, CD248, and their combination as indicators in early pregnancy maternal plasma was 0.681, 0.609, and 0.695, respectively. Conclusions and Clinical Relevance The present study is the first to obtain preliminary evidence that CD109 and CD248 can predict GDM during early pregnancy, as well as providing proteome‐level insights into this disease's pathological mechanisms.

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“…Increased placental weight and size (Lao et al, 1997;Taricco et al, 2003) occur as an attempt to increase the surface of oxygen exchange and counteract the GDM-associated fetal hypoxia, which is characterized by an unbalance between oxygen demands and supply (Gauster et al, 2012). Other morphologic features such as chorangiosis, marked by an increased number of capillaries in the periphery of chorionic villi, have been registered (Aldahmash et al, 2021;Augustine & Pulikkathodi, 2016;Daskalakis et al, 2008). However, the GDM-induced morphological and vascular alterations (e.g., calcification, decidual vasculopathy, villous edema, among others; Aldahmash et al, 2021) may further exacerbate the hypoxic intrauterine environment (Figueroa et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…Other morphologic features such as chorangiosis, marked by an increased number of capillaries in the periphery of chorionic villi, have been registered (Aldahmash et al, 2021;Augustine & Pulikkathodi, 2016;Daskalakis et al, 2008). However, the GDM-induced morphological and vascular alterations (e.g., calcification, decidual vasculopathy, villous edema, among others; Aldahmash et al, 2021) may further exacerbate the hypoxic intrauterine environment (Figueroa et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring

Tocantins

Diniz

Grilo

et al. 2022

WIREs Mechanisms of Disease

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Cardiovascular disease (CVD) is the biggest killer worldwide, composing a major economic burden for health care systems. Obesity and diabetes are dual epidemics on the rise and major risk factors predisposing for CVD. Increased obesity‐ and diabetes‐related incidence is now observed among children, adolescents, and young adults. Gestational diabetes mellitus (GDM) is the most common metabolic pregnancy disorder, and its prevalence is rapidly increasing. During pregnancies complicated by GDM, the offspring are exposed to a compromised intrauterine environment characterized by hyperglycemic periods. Unfavorable in utero conditions at critical periods of fetal cardiac development can produce developmental adaptations that remodel the cardiovascular system in a way that can contribute to adult‐onset of heart disease due to the programming during fetal life. Epidemiological studies have reported increased cardiovascular complications among GDM‐descendants, highlighting the urgent need to investigate and understand the mechanisms modulated during fetal development of in utero GDM‐exposed offspring that predispose an individual to increased CVD during life. In this manuscript, we overview previous studies in this area and gather evidence linking GDM and CVD development in the offspring, providing new insights on novel mechanisms contributing to offspring CVD programming by GDM, from the role of maternal–fetal interactions to their impact on fetal cardiovascular development, how the perpetuation of cardiac programming is maintained in postnatal life, and advance the intergenerational implications contributing to increased CVD premature origin. Understanding the perpetuation of CVD can be the first step to manage and reverse this leading cause of morbidity and mortality. This article is categorized under: Reproductive System Diseases > Molecular and Cellular Physiology Cardiovascular Diseases > Molecular and Cellular Physiology Metabolic Diseases > Genetics/Genomics/Epigenetics

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Gestational diabetes mellitus induces placental vasculopathies

Cited by 20 publications

References 36 publications

Association of Placental Risk Factors and Birth Weight of Newborn: A Case–Control Study

Association of Placental Risk Factors and Birth Weight of Newborn: A Case–Control Study

Placental and plasma early predictive biomarkers for gestational diabetes mellitus

The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring

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