Gestational diabetes mellitus prevalence: Effect of the laboratory analytical variation

Agarwal, Mukesh; Dhatt, Gurdeep S.; Othman, Yusra

doi:10.1016/j.diabres.2015.06.001

Cited by 22 publications

(15 citation statements)

References 13 publications

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“…The estimated prevalence of GDM in Kuwait (12.6%, 95% CI: 10.4%, 14.8%) is similar to estimates found in neighboring countries such as Bahrain (10.1%) [22], UAE (13.3%) [23], Saudi Arabia (15.4%) [24], and Qatar (16.3%) [25]. Comparative data for GDM in the United States [20], Australia [26], and Sweden [27] range from 4.6-9.2%, 4.8-6.7%, and 0.4-1.5%, respectively.…”

Section: Discussionsupporting

confidence: 68%

Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study

Groof

Garashi

Husain

et al. 2019

Journal of Diabetes Research

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Objective. Gestational diabetes mellitus (GDM) is a growing global public health problem that can have short- and long-term health consequences for the mother and the child. Despite its criticalness, many countries still do not have the epidemiological data which could guide them in responding to the problem. Due to the lack of knowledge on GDM and the fact that diabetes and obesity are high in Kuwait, this study sought to estimate the prevalence of GDM and determine its risk factors and outcomes. Methods. This cross-sectional study enrolled 947 mothers living in Kuwait, who had given birth within the previous four years. Participants were recruited from primary health care clinics and public hospitals. GDM status was self-reported by the mother. Associations between exposures and outcomes were evaluated using logistic regression, and adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated. Results. Of the 868 mothers with no prior history of diabetes mellitus, 109 (12.6%, 95% CI: 10.4, 14.8) reported having been given a GDM diagnosis during their last pregnancy. The prevalence of GDM increased with maternal age and prepregnancy body mass index. GDM was positively associated with caesarean section delivery (aOR=1.76, 95% CI: 1.17, 2.66) and fetal macrosomia (aOR=2.36, 95% CI: 1.14, 4.89). Conclusion. GDM is prevalent in Kuwait and is associated with poor maternal, fetal, and neonatal outcomes. To date, GDM has received little attention, and there is a need for more research to identify and respond to individual and public health implications of GDM in Kuwait.

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Section: Discussionsupporting

confidence: 68%

Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study

Groof

Garashi

Husain

et al. 2019

Journal of Diabetes Research

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“…However, the prevalence of GDM and the class-risk rate were similar to those reported by us before [28,29,36,37], thus suggesting that a selection bias was very unlikely. In addition, the enrollment of pregnant women and the FTCT and OGTT tests were performed at a single center, and this, in our opinion, constitutes a strength of this work, which contributes to the minimization of the bias linked to inter-laboratory analytical variations [38]. Another strength of our study is the uniformity of GDM diagnosis among the study participants; in fact, we only enrolled women in whom screening for GDM was performed by adopting the new IADPSG cut-offs.…”

Section: Discussionmentioning

confidence: 99%

First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

Visconti

Quaresima

Chiefari

et al. 2019

IJERPH

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Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM.

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“…We are unable to determine the cause for the marked difference in fasting glucose distribution in the OCC compared with other cohorts. Agarwal et al (15) have notedthat laboratory variations, well within acceptable limits, may be associated with a halving or doubling of GDM prevalence. The Danish Inter99 population study (outside pregnancy) reported that lowering the threshold for impaired fasting glucose (IFG) from 6.0 mmol/L (recommended by WHO) to 5.5 mmol/L (recommended by the American Diabetes Association)would create a "pandemic" of prediabetes (16), increasing IFG from 12 to 38% in their cohort.…”

Section: Discussionmentioning

confidence: 99%

Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds

McIntyre

Jensen

et al. 2018

Diabetes Care

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Gestational diabetes mellitus prevalence: Effect of the laboratory analytical variation

Cited by 22 publications

References 13 publications

Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study

Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study

First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds

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