Gestational diabetes mellitus yesterday, today and tomorrow: A 13 year italian cohort study

Bordin, Paolo; Dotto, Luciana; Liliana, Battistella; Elena, Rosso; Pecci, Lucia; Valent, Francesca; Collarile, Paolo; Vanin, M

doi:10.1016/j.diabres.2020.108360

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…This study found that pregnant women with GDM aged 20–24 years was a protective factor for macrosomia, and AMA with GDM was a risk factor for macrosomia and LGA. This was consistent with the previous research findings, which found that macrosomia and LGA were always more common in pregnant women with GDM 5 , 30 , and AMA was also a risk factor for macrosomia and LGA 12 , 28 . Pregnant women with AMA and GDM was lower for metabolize glucose, and excessive placental transport of glucose and other nutrients from pregnant woman to fetus caused abnormal fetal growth, including macrosomia and LGA 30 .…”

Section: Discussionsupporting

confidence: 93%

“…This was consistent with the previous research findings, which found that macrosomia and LGA were always more common in pregnant women with GDM 5 , 30 , and AMA was also a risk factor for macrosomia and LGA 12 , 28 . Pregnant women with AMA and GDM was lower for metabolize glucose, and excessive placental transport of glucose and other nutrients from pregnant woman to fetus caused abnormal fetal growth, including macrosomia and LGA 30 . The length of the biparietal diameter of macrosomia increased, and the fetal position appeared abnormally 31 , and pregnant women with AMA were at increased risk of breech presentation 32 .…”

Section: Discussionsupporting

confidence: 93%

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Risk of adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus by age: a multicentric cohort study in Hebei, China

Zhang,

Tian,

Zhang

et al. 2024

Sci Rep

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Gestational diabetes mellitus (GDM) is an unique metabolic disorder that occurs during pregnancy. Both GDM and advanced age increase the risk of adverse pregnancy outcomes. This study used a GDM cohort study to investigate the role of age in the adverse pregnancy outcomes for pregnant women with GDM. From 2015 to 2021, 308,175 pregnant women were selected, and the data received from 22 hospitals by the Hebei Province Maternal Near Miss Surveillance System. There were 24,551 pregnant women with GDM that were divided into five groups by age (20–24, 25–29, 30–34, 35–39, 40–44 years old). Because the prevalence of adverse pregnancy outcomes was lower in pregnant women with GDM aged 25–29, they were used as a reference group (P < 0.05). Compared with GDM women aged 25–29 years, GDM women aged 35–44 years had a significant higher risk of cesarean delivery (aOR: 2.86, 95% CI 2.52–3.25) (P < 0.001), abnormal fetal position (aOR: 1.78, 95% CI 1.31–2.37) (P < 0.001), pre-eclampsia (aOR: 1.28, 95% CI 1.01–1.61) (P < 0.05), macrosomia (aOR: 1.25, 95% CI 1.08–1.45) (P < 0.05), and large for gestational age (LGA) (aOR: 1.16, 95% CI 1.02–1.31) (P < 0.05), GDM women aged 40–44 years had a higher risk of placenta previa (aOR: 2.53, 95% CI 1.01–6.35) (P < 0.05), anemia (aOR: 3.45, 95% CI 1.23–9.68) (P < 0.05) and small for gestational age (aOR: 1.32, 95% CI 1.01–1.60) (P < 0.05). Advanced maternal age was an independent risk factor for abnormal fetal position, pre-eclampsia, anemia, macrosomia, and LGA in pregnant women with GDM.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Risk of adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus by age: a multicentric cohort study in Hebei, China

Zhang,

Tian,

Zhang

et al. 2024

Sci Rep

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“…First, we observed a different therapy load in HMPC women. In our population, HMPC women were younger, confirming findings of other studies conducted in Italy [ 16 ] and required more frequent insulin treatment than Caucasian women born in Italy. Over time, an exchange of habits between HPMC people and the host population has taken place.…”

Section: Discussionsupporting

confidence: 90%

“…Overall, newborn weight was independently predicted by gestational age at the delivery and GDM in previous pregnancies, newborn height by gestational age and insulin treatment, and head circumference by gestational age at delivery. In a recent large study (894 GDM women) conducted over 13 years in the north of Italy on a multiethnic population [ 16 ], macrosomia was associated with BMI and weight gain, but also with previous macrosomia or GDM, confirming our findings.…”

Section: Discussionsupporting

confidence: 90%

Gestational Diabetes Mellitus: Clinical Characteristics and Perinatal Outcomes in a Multiethnic Population of North Italy

Caputo

Bullara

Mele

et al. 2021

International Journal of Endocrinology

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Aim. To evaluate clinical characteristics and perinatal outcomes in a heterogeneous population of Caucasians born in Italy and High Migration Pressure Countries (HMPC) women with GDM living in Piedmont, North Italy. Methods. We retrospectively analyzed data from 586 women referring to our unit (2015–2020). Epidemiological (age and country of origin) and clinical-metabolic features (height, weight, family history of DM, parity, previous history of GDM, OGTT results, and GDM treatment) were collected. The database of certificates of care at delivery was consulted in relation to neonatal/maternal complications (rates of caesarean sections, APGAR score, fetal malformations, and neonatal anthropometry). Results. 43.2% of women came from HMPC; they were younger p < 0.0001 and required insulin treatment more frequently than Caucasian women born in Italy (χ2 = 17.8, p = 0.007 ). Higher fasting and 120-minute OGTT levels and gestational BMI increased the risk of insulin treatment (OGTT T0: OR = 1.04, CI 95% 1.016–1.060, p = 0.005 ; OGTT T120: OR = 1.01, CI 95% 1.002–1.020, p = 0.02 ; BMI: OR = 1.089, CI 95% 1.051–1.129, p < 0.0001 ). Moreover, two or more diagnostic OGTT glucose levels doubled the risk of insulin therapy (OR = 2.03, IC 95% 1.145–3.612, p = 0.016 ). We did not find any association between ethnicities and neonatal/maternal complications. Conclusions. In our multiethnic GDM population, the need for intensive care and insulin treatment is high in HPMC women although the frequency of adverse peripartum and newborn outcomes does not vary among ethnic groups. The need for insulin therapy should be related to different genetic backgrounds, dietary habits, and Nutrition Transition phenomena. Thus, nutritional intervention and insulin treatment need to be tailored.

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“…Maternal obesity during pregnancy represents a danger for short- and long-term health outcomes for both mothers and children [ 2 , 3 , 4 ]. Indeed, up to 50% of obese pregnant women develop Gestational Diabetes Mellitus (GDM) [ 5 ], and the offspring of obese and diabetic mothers are at higher risk of developing metabolic and cardiovascular diseases in early childhood and later in their adulthood [ 6 ], with possible transgenerational effects [ 7 ]. Moreover, newborns of obese and diabetic mothers have been recently shown to be hypoxic, acidemic, and to have increased oxidative markers compared to normal-weight pregnancies [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Profiling in the Saliva of Obese Pregnant Women

et al. 2022

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Maternal obesity is associated with inflammation and oxidative stress, strongly impacting the intrauterine environment with detrimental consequences for both mother and offspring. The saliva is a non-invasive biofluid reflecting both local and systemic health status. This observational study aimed to profile the epigenetic signature in the saliva of Obese (OB) and Normal-Weight (NW) pregnant women. Sixteen NW and sixteen OB Caucasian women with singleton spontaneous pregnancies were enrolled. microRNAs were quantified by the OpenArray Platform. The promoter region methylation of Suppressor of Cytokine Signaling 3 (SOCS3) and Transforming Growth Factor Beta 1 (TGF-Beta1) was assessed by pyrosequencing. There were 754 microRNAs evaluated: 20 microRNAs resulted in being differentially expressed between OB and NW. microRNA pathway enrichment analysis showed a significant association with the TGF-Beta signaling pathway (miTALOS) and with fatty acids biosynthesis/metabolism, lysine degradation, and ECM–receptor interaction pathways (DIANA–miRPath). Both SOCS3 and TGF-Beta1 were significantly down-methylated in OB vs. NW. These results help to clarify impaired mechanisms involved in obesity and pave the way for the understanding of specific damaged pathways. The characterization of the epigenetic profile in saliva of pregnant women can represent a promising tool for the identification of obesity-related altered mechanisms and of possible biomarkers for early diagnosis and treatment of pregnancy-adverse conditions.

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Gestational diabetes mellitus yesterday, today and tomorrow: A 13 year italian cohort study

Cited by 7 publications

References 31 publications

Risk of adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus by age: a multicentric cohort study in Hebei, China

Risk of adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus by age: a multicentric cohort study in Hebei, China

Gestational Diabetes Mellitus: Clinical Characteristics and Perinatal Outcomes in a Multiethnic Population of North Italy

Epigenetic Profiling in the Saliva of Obese Pregnant Women

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