Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice

Yu, Dainan; Jiang, Xun; Ge, Wenjing; Qiao, Bo; Zhang, Dalei; Liu, Hui; Kuang, Haibin

doi:10.1016/j.fct.2021.112766

Cited by 16 publications

(8 citation statements)

References 35 publications

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“…Additionally, HSD3B1 is implicated in the hydroxylation metabolism of estrogen, a process closely associated with the reproductive capacity of animals [ 31 ]. CYP11A1 plays a pivotal role in ovarian development and function, as well as various other physiological processes in both sexes [ 32 ]. Previous studies have demonstrated that modulating the expression of CYP11A1 and HSD3B1 can stimulate luteal angiogenesis, mitigate fluctuations in sex hormones in mice, and confer benefits to pregnancy [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Ovary Transcriptome among Wanyue Black and Yorkshire Gilts Using RNA-Seq

Zhang,

Chen,

Liu

et al. 2024

Veterinary Sciences

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Pubertal genetic variations between the indigenous Chinese Wanyue Black pig breed and the imported Yorkshire breed significantly impact their reproductive capacity. In order to identify the differentially expressed genes, gene networks, and metabolic pathways in ovary transcriptome of gilts, the serum hormone levels were analyzed by ELISA, and RNA-seq was performed to analyze ovarian genes. Our results reveal higher estradiol (E2) levels in Wanyue black gilts compared to Yorkshire gilts, while Yorkshire gilts exhibit elevated progesterone (P4) and GnRH levels. We identified a total of 154 differentially expressed genes (DEGs), with 87 up-regulated and 67 down-regulated genes in the Wanyue black gilts ovaries compared to the Yorkshire gilts. GO enrichment analysis unveiled the participation of DEGs in processes such as “Reproduction”, “Reproductive system development”, and “Ovarian follicle development”. Moreover, KEGG enrichment analysis revealed the involvement of DEGs in multiple signaling pathways associated with hormone biosynthesis and puberty, encompassing “Steroid hormone biosynthesis”, “Estrogen signaling pathway”, and “Prolactin signaling pathway”. The subsequent bioinformatics analysis identified nine functional genes that potentially contribute to the disparity in ovaries between Wanyue black gilts and Yorkshire gilts. This study offers significant insights into the endocrine and genetic aspects of pubertal development in gilts.

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Ovary Transcriptome among Wanyue Black and Yorkshire Gilts Using RNA-Seq

Zhang,

Chen,

Liu

et al. 2024

Veterinary Sciences

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“…Most studies focus on the developmental toxicological effects involving liver structure or function, blood cells or oxidative stress 27 , 42 – 44 . Limited studies performed on pregnant mice show changes in ovarian corpora lutea 45 and placenta 46 . One study presents disturbances in skeletal system development in fetuses exposed to ACR (0.05, 1, 5 and 10 mg/kg b.w./day) 47 .…”

Section: Discussionmentioning

confidence: 99%

Maternal acrylamide exposure changes intestinal epithelium, immunolocalization of leptin and ghrelin and their receptors, and gut barrier in weaned offspring

Muszyński

Hułas-Stasiak

Dobrowolski

et al. 2023

Sci Rep

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Acrylamide (ACR) is an amide formed as a byproduct in many heat-processed starchy-rich foods. In utero ACR exposure has been associated with restricted fetal growth, but its effects of postnatal functional development of small intestine is completely unknown. The current study investigated the time- and segment-dependent effects of prenatal ACR exposure on morphological and functional development of small intestine in weaned rat offspring. Four groups of pregnant female Wistar rats were exposed to ACR (3 mg/kg b.w./day) for 0, 5, 10 and 15 days during pregnancy. Basal intestinal morphology, immunolocalization of gut hormones responsible for food intake and proteins of intestinal barrier, activity of the intestinal brush border disaccharidases, apoptosis and proliferation in intestinal mucosa were analyzed in offspring at weaning (postnatal day 21). The results showed that in utero ACR exposure disturbs offspring gut structural and functional postnatal development in a time- and segment-depended manner and even a short prenatal exposure to ACR resulted in changes in intestinal morphology, immunolocalization of leptin and ghrelin and their receptors, barrier function, activity of gut enzymes and upregulation of apoptosis and proliferation. In conclusion, prenatal ACR exposure disturbed the proper postnatal development of small intestine.

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“…AA may induce ovarian dysfunction by increasing the proportions of apoptosisrelated genes [72]. It has been reported that AA exposure may inhibit the endocrine function of lutein in pregnancy through ovarian oxidative stress and apoptosis [73]. AA could also promote the apoptosis of mouse extracellular cumulus granulosa cells, delay cell maturation, and decrease developmental potential [74].…”

Section: Acrylamide Induces Cell Apoptosis In Reproductivementioning

confidence: 99%

“…AA during pregnancy mainly caused placental development arrest by regulating the expressions of key placental AA genes and labyrinthine vessels, inhibiting proliferation and inducing apoptosis. Moreover, P-ERK1/2 and p53 may be involved in the process [73,77]. In addition, it is also shown that benzopyrene had an obvious synergistic efect on gonadal cell apoptosis in Caenorhabditis elegans [78].…”

Section: Acrylamide Induces Cell Apoptosis In Reproductivementioning

confidence: 99%

Research Progress of Programmed Cell Death Induced by Acrylamide

Wang

et al. 2023

Journal of Food Quality

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Acrylamide exposure through environment pollution and diet is very common in daily life. With the deepening of the study on the toxicity of acrylamide, it has attracted widespread attention for the effects of acrylamide on multiple organs through affecting a variety of programmed cell death. Multiple studies have shown that acrylamide could exert its toxic effect by inducing programmed cell death, but its specific molecular mechanism is still unclear. In this review, the research on the main forms of programmed cell death (apoptosis, autophagy, and programmed necrosis) induced by acrylamide and their possible mechanisms are reviewed. This review may provide basic data for further research of acrylamide and prevention of its toxicity.

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Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice

Cited by 16 publications

References 35 publications

Comparative Analysis of the Ovary Transcriptome among Wanyue Black and Yorkshire Gilts Using RNA-Seq

Comparative Analysis of the Ovary Transcriptome among Wanyue Black and Yorkshire Gilts Using RNA-Seq

Maternal acrylamide exposure changes intestinal epithelium, immunolocalization of leptin and ghrelin and their receptors, and gut barrier in weaned offspring

Research Progress of Programmed Cell Death Induced by Acrylamide

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