Gestational Hypertension, Preeclampsia, and Risk of Testicular Cancer

Pettersson, Andreas; Richiardi, Lorenzo; Cnattingius, Sven; Kaijser, Magnus; Akre, Olof

doi:10.1158/0008-5472.can-08-2309

Cited by 16 publications

(10 citation statements)

References 29 publications

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“…Six studies were included in the meta-analysis (Pettersson et al , 2008; Sonke et al , 2007; Coupland et al , 2004; Weir et al , 2000; Moller et al , 1997; Depue et al , 1983). One study (Mori et al , 1988; Mori et al , 1990) involved a very small number of cases (37) and controls (37) and provided two categories of BMI (high [>25] and moderate [<25]) and therefore was not included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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Maternal body mass index and risk of testicular cancer in male offspring: A systematic review and meta-analysis

Alam

Cantwell

Cardwell

et al. 2010

Cancer Epidemiology

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Objectives To date a number of studies have examined the association between maternal weight and testicular cancer risk although results have been largely inconsistent. This systematic review and meta-analysis investigated the nature of this association. Methods Search strategies were conducted in Ovid Medline (1950—2009), Embase (1980—2009), Web of Science (1970—2009), and CINAHL (1937—2009) using keywords for maternal weight (BMI) and testicular cancer. Results The literature search produced 1,689 hits from which 63 papers were extracted. Only 7 studies met the pre-defined criteria. Random effects meta-analyses were conducted. The combined unadjusted OR (95% CI) of testicular cancer in the highest reported category of maternal BMI compared with the moderate maternal BMI was 0.82 (0.65 – 1.02). The Cochran’s Q P value was 0.83 and the corresponding I2 was 0%, both indicating very little variability among studies. The combined unadjusted OR (95% CI) for testicular cancer risk in the lowest reported category of maternal BMI compared to a moderate maternal BMI category was 0.92 (0.75 – 1.12). The Cochran’s Q P value was 0.05 and the corresponding I2 was 54%, indicating evidence of statistical heterogeneity. No association was observed when maternal BMI was treated as a continuous variable. Conclusion This meta-analysis, which included a small number of studies, showed an inverse association between high maternal BMI and testicular cancer risk of borderline statistical significance. Further primary studies with adjustment for appropriate confounders are required.

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Section: Resultsmentioning

confidence: 99%

“…Six studies contributed to the analysis (Pettersson et al , 2008; Sonke et al , 2007; Coupland et al , 2004; Weir et al , 2000; Mori et al , 1990; Depue et al , 1983). The study by Moller et al (Moller et al , 1996) could not be included in this analysis because it reported weight and not BMI.…”

Section: Resultsmentioning

confidence: 99%

Maternal body mass index and risk of testicular cancer in male offspring: A systematic review and meta-analysis

Alam

Cantwell

Cardwell

et al. 2010

Cancer Epidemiology

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“…The placenta is the main source of hormones associated with pregnancy and is typically the tissue that is influenced in PE. Therefore, the PE is characterized by a disturbance in the fundamental balance between steroids and β‐hCG hormones in a manner that reflects abnormal placentation, placental dysfunction and abnormal placental secretory function . This includes elevated β‐hCG production by hyperplastic cytotrophoblastic cells in PE and lowers E2 and excess of PRG values in PE women.…”

Section: Discussionmentioning

confidence: 99%

Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

Al-Kaabi

Hamdan

Al-Matubsi

2020

J of Obstet and Gynaecol

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Aims To evaluate plasma kisspeptin‐10 (KP‐10) as a marker for preeclampsia and assess its relation to altered reproductive hormones in preeclamptic pregnant women. Methods First time pregnant women (n = 100) at 20 weeks of gestation participated in this study and divided into preeclamptics (n = 60) and normotensives (n = 40). KP‐10, luteinizing hormone (LH), follicle stimulating hormone (FSH), beta‐human chorionic gonadotropin (β‐hCG), estradiol (E2) and progesterone were evaluated during 2nd and 3rd trimesters of pregnancy for all women. Results Kisspeptin‐10 levels were reduced in preeclampsia (PE) women compared with normotensive pregnancies. In the 2nd trimester, area under receiver–operator characteristic (ROC) curve was 0.662, positive and negative predictive values were 32.8 and 94.6, and test sensitivity and specificity were 55% and 87.5%, respectively. In the 3rd trimester, area under ROC curve was 0.747 positive and negative predictive values were 22.2 and 97.3, and test sensitivity and specificity were 83.3% and 67.5%, respectively. In PE patients, plasma KP‐10 demonstrated an inverse correlation with E2 (during the 2nd trimester), LH and FSH (during the 3rd trimester), and positively correlated with β‐hCG (during the 3rd trimester). Conclusion This study showed significantly reduced plasma KP‐10 levels in PE women. This suggests that KP‐10 may play an important role in the pathophysiology of PE. Therefore, combined with previous studies, to diagnose the PE, testing for maternal KP‐10 plasma levels may be useful as an effective screening, but because of low positive predictive value and inadequate test sensitivity, screening cannot be recommended. Furthermore, KP‐10 in PE patients demonstrated significant positive correlation with β‐hCG.

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“…Thus, a delayed androgen activity may be associated with a reduced lifetime risk for prostate [42] and testicular cancer. [43,44]…”

Section: Discussionmentioning

confidence: 99%

Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study

et al. 2016

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BackgroundChildren born after preeclampsia may have a dominant androgen profile in puberty compared with other children. Circulating androgen concentrations at 11–12 years of age were compared between offspring born after preeclampsia, and children whose mothers did not have preeclampsia.MethodsA total of 611 mother-offspring pairs were followed up 11 (daughters) or 12 (sons) years after birth: 218 pairs in the preeclampsia group, and 383 pairs without preeclampsia. Circulating total testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor I (IGF-I) were measured in the children. In boys, testicular volume was also measured.ResultsAmong girls born after preeclampsia, DHEAS concentrations were higher than in unexposed girls (p<0.001), however, girls born after preeclampsia with severe features had the lowest DHEAS levels. In contrast, testosterone concentrations were highest in girls born after preeclampsia with severe features, both compared to other girls in the preeclampsia group, and compared to unexposed girls (p<0.001). For boys, testosterone concentrations were higher in the preeclampsia group compared with unexposed boys (p<0.001), and boys born after preeclampsia with severe features had the lowest concentrations of DHEAS. Compared with unexposed boys, testicular volume (p = 0.015) and IGF-I (p = 0.004) were higher for boys in the preeclampsia group, except for boys in the clinically severe preeclampsia group.ConclusionsIn utero exposure to preeclampsia is associated with androgen hormonal patterns in early puberty that depend on clinical severity of preeclampsia and sex of the offspring. The hormonal differences may reflect different timing of pubertal development, and may have consequences for future health of the offspring.

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Gestational Hypertension, Preeclampsia, and Risk of Testicular Cancer

Cited by 16 publications

References 29 publications

Maternal body mass index and risk of testicular cancer in male offspring: A systematic review and meta-analysis

Maternal body mass index and risk of testicular cancer in male offspring: A systematic review and meta-analysis

Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study

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