2013
DOI: 10.1001/jamapsychiatry.2013.896
|View full text |Cite
|
Sign up to set email alerts
|

Gestational Influenza and Bipolar Disorder in Adult Offspring

Abstract: IMPORTANCE Gestational influenza has been associated previously with schizophrenia in offspring, but the relationship between this exposure and bipolar disorder (BD) is unclear. The identification of gestational influenza as a risk factor for BD may have potential for preventive approaches. OBJECTIVE To test the hypothesis that maternal influenza during pregnancy is related to BD among offspring. DESIGN Nested case-control study of a population-based birth cohort from the Child Health and Development Study (CH… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
140
0
1

Year Published

2014
2014
2024
2024

Publication Types

Select...
5
3
1

Relationship

0
9

Authors

Journals

citations
Cited by 212 publications
(143 citation statements)
references
References 33 publications
2
140
0
1
Order By: Relevance
“…The story reported findings of a four-fold increased risk of bipolar disorder in adult offspring if a mother had influenza during pregnancy 6 , but it emphasized that the overall risk observed was small and that bipolar disorder is treatable. It stated that the study considered only one of many possible risk factors and did not establish cause and effect.…”
Section: Context Is Keymentioning
confidence: 99%
“…The story reported findings of a four-fold increased risk of bipolar disorder in adult offspring if a mother had influenza during pregnancy 6 , but it emphasized that the overall risk observed was small and that bipolar disorder is treatable. It stated that the study considered only one of many possible risk factors and did not establish cause and effect.…”
Section: Context Is Keymentioning
confidence: 99%
“…Maternal infectious or inflammatory insults during pregnancy have been repeatedly implicated in the etiology of developmental neuropsychiatric disorders, including schizophrenia (Brown and Derkits, 2010;Canetta et al, 2014b), autism (Atladóttir et al, 2010;Brown et al, 2014), and bipolar disorder (Canetta et al, 2014a;Parboosing et al, 2013). Preclinical support for these epidemiological associations has been obtained by various translational rodent models demonstrating multiple brain and behavioral abnormalities following prenatal exposure to infection and/or immune activation (reviewed in Boksa, 2010;Harvey and Boksa, 2012;Meyer, 2014;.…”
Section: Introductionmentioning
confidence: 99%
“…Expressed both in the periphery and in the central nervous system (CNS) as well as in the maternal-fetal interface, they are able to initiate immediate immune responses against invading pathogens with potential implications in neuropathological processes [25][26][27]. This is of particular relevance since a variety of infectious agents viz Borna virus, Toxoplasma gondii, influenza or herpes simplex I have been associated with BD [28][29][30][31]. The currently assumed mechanism, common to these infectious insults in causing such risk, is defective central/systemic immune/inflammatory responses that interfere with expression of pro-inflammatory cytokines by microglia, the resident immune cells in the CNS known to express the full repertoire of TLRs [32].…”
Section: Introductionmentioning
confidence: 99%