Gestational microbiome: metabolic perturbations and developmental programming

Ellberg, Charlotte C.; Olomu, Isoken N.; Vyas, Arpita

doi:10.1530/rep-21-0241

Cited by 8 publications

(6 citation statements)

References 105 publications

(133 reference statements)

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“…Maternal diet, obesity, gestational weight gain, and gestational diabetes mellitus are additional factors that modulate the nature of the microbiota that is transferred to the fetus and neonate. This topic has been extensively reviewed elsewhere ( 46 , 47 ), and overweight and other aspects of diet are discussed below.…”

Section: Evolution and Necessary Microbial Exposuresmentioning

confidence: 99%

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Rook

2022

mSystems

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Section: Evolution and Necessary Microbial Exposuresmentioning

confidence: 99%

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Rook

2022

mSystems

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“…Elevated levels of oestrogens contribute to the growth of the vaginal lining and increase the glycogen accumulation in the vaginal mucus [ 44 ]. Lactobacillus utilises glycogen to produce lactic acid and bacteriocins [ 41 , 45 ], protecting against vaginal dysbiosis and suppressing opportunistic infections. There is also a noticeable increase in the prevalence of Proteobacteria and Actinobacteria during the third trimester [ 21 ].…”

Section: Influence Of Maternal Microbiota On Pregnancymentioning

confidence: 99%

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

Adamczak,

Werblińska,

Jamka

et al. 2024

Biomedicines

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In recent years, the number of scientific publications on the role of intestinal microbiota in shaping human health, as well as the occurrence of intestinal dysbiosis in various disease entities, has increased dynamically. However, there is a gap in comprehensively understanding the factors influencing a child’s gut microbiota. This review discusses the establishment of gut microbiota and the immunological mechanisms regulating children’s microbiota, emphasising the importance of prioritising the development of appropriate gut microbiota in a child from the planning stages of pregnancy. The databases PubMed, Web of Sciences, Cochrane, Scopus and Google Scholar were searched to identify relevant articles. A child’s gut microbiota composition is influenced by numerous factors, such as diet during pregnancy, antibiotic therapy, the mother’s vaginal microbiota, delivery method, and, later, feeding method and environmental factors. During pregnancy, the foetus naturally acquires bacterial strains from the mother through the placenta, thereby shaping the newborn’s immune system. Inappropriate maternal vaginal microbiota may increase the risk of preterm birth. Formula-fed infants typically exhibit a more diverse microbiota than their breastfed counterparts. These factors, among others, shape the maturation of the child’s immune system, impacting the production of IgA antibodies that are central to cellular humoral immune defence. Further research should focus on identifying specific microbiota–immune system interactions influencing a child’s immune health and developing personalised treatment strategies for immune-related disorders.

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“…The gut microbiome is increasingly recognized as a significant contributor to metabolic health [ 30 ] and undergoes various alterations during pregnancy [ 17 , 31 ]. During the first trimester, the gut microbiome mirrors that of healthy, non-pregnant women, but shifts substantially in composition and structure over the course of pregnancy [ 32 ].…”

Section: Microbiome Alterations During Pregnancymentioning

confidence: 99%

The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect

Dias,

Pheiffer,

Adam

2023

Microorganisms

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Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, and fetal growth restriction. In the long-term, mothers and children have an increased risk of developing metabolic diseases such as type 2 diabetes and cardiovascular disease. Accumulating evidence suggest that alterations in the maternal microbiome may play a role in the pathogenesis of GDM and adverse pregnancy outcomes. This review describes changes in the maternal microbiome during the physiological adaptations of pregnancy, GDM and adverse maternal and neonatal outcomes. Findings from this review highlight the importance of understanding the link between the maternal microbiome and GDM. Furthermore, new therapeutic approaches to prevent or better manage GDM are discussed. Further research and clinical trials are necessary to fully realize the therapeutic potential of the maternal microbiome and translate these findings into clinical practice.

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Gestational microbiome: metabolic perturbations and developmental programming

Cited by 8 publications

References 105 publications

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect

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