Gestational trophoblastic disease following in vitro fertilization

Huang, Xiaoyan; Wang, Hongwei; Zhao, Xiaofeng; Xu, Xiaoxian; Qiubo, Chen

doi:10.1007/s00404-006-0230-3

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“…7,8 Furthermore, ovarian cancer and gestational trophoblastic disease may be associated with the chronic use of gonadotrophins. 9,10 An alternative approach to IVF that uses minimal ovarian stimulation has previously been outlined by Nargund and Frydman. 11 Natural cycle IVF has received much attention in the past decade, 12 -17 mainly because it appears to be associated with less OHSS because there is minimal ovarian stimulation.…”

Section: Introductionmentioning

confidence: 99%

Modified Natural Cycle for In Vitro Fertilization and Embryo Transfer in Normal Ovarion Responders

2010

J Int Med Res

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Section: Introductionmentioning

confidence: 99%

Modified Natural Cycle for In Vitro Fertilization and Embryo Transfer in Normal Ovarion Responders

2010

J Int Med Res

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Complete hydatidiform mole and a coexistent fetus following ovulation induction in a patient with Sheehan’s syndrome: a first case report and review of literature

Huang

Liang

Huang

et al. 2013

Arch Gynecol Obstet

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Pregnancy in Sheehan's syndrome (SS) is extremely rare. We present the first reported case of twin pregnancy with complete hydatiform mole (CHM) and a coexistent fetus (CHCF) in a patient with SS. A 29-year-old Chinese patient with SS became pregnant following one cycle of ovulation induction with human menopausal gonadotropin after secondary infertility. A normal live fetus and a low echogenic mass suspected hydatidiform mole (HM) were detected by ultrasound examinations at gestational week 8. The couple highly desired to continue the pregnancy because it is very hard to get pregnant for the patients with SS. However, the pregnancy was terminated for the size of the HM component increased rapidly at gestational week 15. Histological examinations confirmed CHCF. Genetic studies showed that the CHM genome was derived from paternal diploidy, and the normal fetus was from biparental genomes. Furthermore, a literature review on these topics is included. This case highlighted that even in a patient with SS, twin pregnancy with CHCF can still occur after ovulation induction.

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Gestational trophoblastic disease following in vitro fertilization

Abstract: It is unlikely that this complication is directly related to the technique of IVF itself but rather the characteristics of women and the partner attending for assisted conception make them more at risk of molar pregnancies. The management includes prompt curettage and regular follow-up.

Cited by 2 publications

References 10 publications

Modified Natural Cycle for In Vitro Fertilization and Embryo Transfer in Normal Ovarion Responders

Modified Natural Cycle for In Vitro Fertilization and Embryo Transfer in Normal Ovarion Responders

Complete hydatidiform mole and a coexistent fetus following ovulation induction in a patient with Sheehan’s syndrome: a first case report and review of literature

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